A5017940876- Lymphoma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Single-cell and spatial transcriptomics
- CAR-T cell therapy research
- Statistical Methods in Clinical Trials
- Chronic Lymphocytic Leukemia Research
- Lung Cancer Treatments and Mutations
- Viral-associated cancers and disorders
- CNS Lymphoma Diagnosis and Treatment
- RNA Research and Splicing
- Molecular Biology Techniques and Applications
- Cell Image Analysis Techniques
- Metallurgical Processes and Thermodynamics
- Global Cancer Incidence and Screening
- Optimization and Search Problems
- T-cell and B-cell Immunology
- Optimism, Hope, and Well-being
- Advanced Manufacturing and Logistics Optimization
- Additive Manufacturing Materials and Processes
- Advanced Numerical Methods in Computational Mathematics
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Soil, Finite Element Methods
- Injection Molding Process and Properties
- Nuclear Materials and Properties
Kunming Medical University
2024
National University Health System
2018-2023
New Technology (Israel)
2023
Smile Train
2023
National University Cancer Institute, Singapore
2018-2023
National Clinical Research
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Xiangya Hospital Central South University
2023
Central South University
2023
Nationwide Children's Hospital
2022
Although combination therapy is the standard of care for relapsed/refractory non-Hodgkin's lymphoma (RR-NHL), treatment chosen an individual patient empirical, and response rates remain poor in individuals with chemotherapy-resistant disease. Here, we evaluate experimental-analytic method, quadratic phenotypic optimization platform (QPOP), prediction patient-specific drug efficacy from a limited quantity biopsied tumor samples. In this prospective study, enrolled 71 patients RR-NHL (39 B...
Primary mediastinal large B-cell lymphoma (PMBCL) is a distinct clinico-pathological subtype of diffuse with unclear prognostic factors and limited clinical data. Optimal treatment role for radiotherapy not fully defined. We performed multicenter retrospective review 124 patients newly diagnosed PMBCL between 2001 2016. Treatment regimens were R-CHOP (n = 41), + RT 37), DA-EPOCH-R 46). 6% 3) in the group received RT. With median follow up 45 months, overall 5-year OS PFS was 89.4% 82.4%,...
The number of treatment options for myeloma and indolent lymphoma are expanding at an exponential rate, with few direct head-to-head comparisons on which to base efficacy measures. We sought understand how patients, their caregivers physicians weigh characteristics in order come a decision option pursue.Patients, were recruited interviewed until data saturation was reached. A qualitative, thematic analysis done identify themes important each stakeholder.We found that, while all three groups...
Cancers often overexpress multiple clinically relevant oncogenes, but it is not known if combinations of oncogenes in cellular subpopulations within a cancer influence clinical outcomes. Using quantitative multispectral imaging the prognostically MYC, BCL2, and BCL6 diffuse large B-cell lymphoma (DLBCL), we show that percentage cells with unique combination MYC+BCL2+BCL6- (M+2+6-) consistently predicts survival across four independent cohorts (n = 449), an effect observed other including...
Abstract Mantle cell lymphoma (MCL) is an uncommon and typically aggressive form of lymphoma. Although often initially chemosensitive, relapse common. Several induction conditioning regimens are used in transplant‐eligible patients, the optimal approach remains unknown. We performed international, retrospective study patients to assess impact chemoimmunotherapy on clinical outcomes. identified 228 meeting inclusion criteria. Baseline characteristics were similar among groups except for some...
In this paper we outline the development of a scalable PBF thermal history simulation built on CAPL and based melt pool physics dynamics. The new approach inherits linear scalability from has three novel ingredients. Firstly, to simulate laser scanning solid surface, discretize entire domain instead only manufacturing toolpath by appending fictitious paths toolpath. Secondly, overlapping toolpaths, path-scale simulations are initialized Voronoi diagram for line segments discretized Lastly,...
Abstract INTRODUCTION: Non-small cell lung cancer (NSCLC) is a prevalent and deadly type. Despite advances in targeted therapies NSCLC, one-third of adenocarcinomas lack actionable oncogenes, limiting therapy options. To address these challenges, CRISPR screening has emerged as tool to unveil dependencies. However, current genome-scale studies rely heavily on 2D monolayer models that fail replicate vivo tumor biology due altered gene/protein expressions, absence cell-extracellular matrix...
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Pancreatic adenocarcinoma (PAAD) is a highly aggressive malignant tumor with poor prognosis. Integrin subunit genes (ITGs) serve as biomarkers for various types of cancers; however, to date, no prognostic research has been conducted on the ITGs in PAAD. This study aims fill this gap by investigating role PAAD RNA-sequencing data, clinicopathological features, and survival information from The Cancer Genome Atlas (TCGA) database were sourced via GTEx. GSE62452 data set was acquired Gene...
Polo-like kinase-1 (PLK1) regulates the MYC-dependent kinome in aggressive B-cell lymphoma. However, role of PLK1 and MYC toward proliferation diffuse large lymphoma (DLBCL) is unknown. We use multiplexed fluorescent immunohistochemistry (fIHC) to evaluate co-localization MYC, Ki67 study their association with DLBCL. The majority (98%, 95% CI 95-100%) MYC/PLK1-double positive tumor cells expressed Ki67, underscoring key MYC/PLK1 circuit proliferation. only 38% (95% 23-40%) 51% 46-51%)...
<p>Supplementary methods. Supplementary Figure 1. Phenotyping of B-cells in non-malignant tissues. A, Quantitation marker positivity across ten tonsil and two reactive lymph node samples (rLN). Analysis is spatially resolved between the GC extra-GC zones. B, Spatial map cellular coordinates based on cell segmentation images 1B. Marker-positivity indicated, a total proportion positive negative cells depicted as pie chart. These maps were used to derive sub-population phenotypes 1C....
<p>Supplementary methods. Supplementary Figure 1. Phenotyping of B-cells in non-malignant tissues. A, Quantitation marker positivity across ten tonsil and two reactive lymph node samples (rLN). Analysis is spatially resolved between the GC extra-GC zones. B, Spatial map cellular coordinates based on cell segmentation images 1B. Marker-positivity indicated, a total proportion positive negative cells depicted as pie chart. These maps were used to derive sub-population phenotypes 1C....
<div>Abstract<p>Cancers often overexpress multiple clinically relevant oncogenes, but it is not known if combinations of oncogenes in cellular subpopulations within a cancer influence clinical outcomes. Using quantitative multispectral imaging the prognostically <i>MYC</i>, <i>BCL2</i>, and <i>BCL6</i> diffuse large B-cell lymphoma (DLBCL), we show that percentage cells with unique combination...
<div>Abstract<p>Cancers often overexpress multiple clinically relevant oncogenes, but it is not known if combinations of oncogenes in cellular subpopulations within a cancer influence clinical outcomes. Using quantitative multispectral imaging the prognostically <i>MYC</i>, <i>BCL2</i>, and <i>BCL6</i> diffuse large B-cell lymphoma (DLBCL), we show that percentage cells with unique combination...
<p>Transcriptomic analysis of M+2+6− high cases and potential role <i>CCND2</i>. <b>A,</b> Correlation observed percentage extent in the BCA cohort with cell-of-origin (COO) DLBCL90-COO signature. Bonferroni corrected Kruskal–Wallis test for ABC vs. others. <b>B,</b> metric GEP cohorts COO signatures. Mean value per group is shown. paired-samples <i>t</i> test. <b>C,</b> evaluated by mfIHC mRNA inference, respectively, genetic...
<p>Prognostic significance of subpopulations after R-CHOP therapy. <b>A,</b> Pooled univariate Cox PH model analysis for MYC, BCL2, and BCL6 single oncogene percentage extent as predictors OS across multiple DLBCL cohorts. Percentage was used a continuous variable in the at 5% increments (see Survival Analysis) an unbiased comparison between variables. <i>P</i> values were Bonferroni corrected oncogenes independently to adjust testing are shown each variable....
<div>Abstract<p>Cancers often overexpress multiple clinically relevant oncogenes, but it is not known if combinations of oncogenes in cellular subpopulations within a cancer influence clinical outcomes. Using quantitative multispectral imaging the prognostically <i>MYC</i>, <i>BCL2</i>, and <i>BCL6</i> diffuse large B-cell lymphoma (DLBCL), we show that percentage cells with unique combination...