A5100412609- Acute Myeloid Leukemia Research
- Histone Deacetylase Inhibitors Research
- Immune Cell Function and Interaction
- Lymphoma Diagnosis and Treatment
- CAR-T cell therapy research
- Chronic Myeloid Leukemia Treatments
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Viral-associated cancers and disorders
- Multiple Myeloma Research and Treatments
- Hematopoietic Stem Cell Transplantation
- Lung Cancer Research Studies
- Chronic Lymphocytic Leukemia Research
- Geological and Geochemical Analysis
- Acute Lymphoblastic Leukemia research
- Virus-based gene therapy research
- earthquake and tectonic studies
- Epigenetics and DNA Methylation
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Ubiquitin and proteasome pathways
- T-cell and B-cell Immunology
- Cancer Cells and Metastasis
- High-pressure geophysics and materials
- Diabetic Foot Ulcer Assessment and Management
- T-cell and Retrovirus Studies
Peking University Shenzhen Hospital
2016-2025
Sun Yat-sen University
2017-2024
Fifth Affiliated Hospital of Sun Yat-sen University
2017-2024
University of Hong Kong - Shenzhen Hospital
2023-2024
Fudan University
2020-2024
Zhongshan Hospital
2024
Lanzhou University
2024
Lanzhou University Second Hospital
2024
Chongqing Medical University
2020-2023
The First Affiliated Hospital, Sun Yat-sen University
2023
It was reported that PD-L1 expression correlated with genetic alterations. Whether regulated by mutant Kirsten rat sarcoma viral oncogene homolog (KRAS) in non-small-cell lung cancer (NSCLC) and the underlying molecular mechanism were largely unknown. In this study, we investigated correlation between KRAS mutation functional significance of PD-1/PD-L1 blockade KRAS-mutant adenocarcinoma. We found associated both human adenocarcinoma cell lines tissues. up-regulated through p-ERK but not...
Abstract While treatment for B-cell malignancies has been revolutionized through the advent of CAR immunotherapy, similar strategies T-cell have limited. Additionally, leukemias and lymphomas can commonly metastasize to CNS, where outcomes are poor options associated with severe side effects. Consequently, development safer more effective alternatives targeting malignant T cells that invaded CNS remains clinically important. CD5 previously shown effectively target various cancers in...
Black and red rice are flavonoid-rich nutritious. However, comprehensive information of flavonoid components in different pigmented varieties remain unclear. Here, we analyze the differences black, red, white by ultra-high-performance liquid chromatography (UPLC) metabolome analysis. Cyanidin-3-glucoside (Cy-3-G), peonidin-3-glucoside (Pe-3-G), quercetin, dihydromyricetin, naringin, taxifolin contents were significantly high black rice. By contrast, catechin epicatechin substantial Cy-3-G...
Abstract Background The heterogeneity of relapsed or refractory (R/R) acute myeloid leukemia (AML) leads to no response venetoclax (VEN)–based therapy in more than half the patients. Genetic characteristics are considered important predictors for treatment adults with AML. However, association genetic outcomes receiving VEN‐based is incompletely understood R/R Objective To evaluate efficacy VEN combined hypomethylating agents (HMA) and identify potential Methods A total 150 AML patients...
Abstract Steroid‐refractory (SR) acute graft‐versus‐host disease (aGVHD) is one of the leading causes early mortality after allogeneic hematopoietic stem cell transplantation (allo‐HSCT). We investigated efficacy, safety, prognostic factors, and optimal therapeutic protocol for SR‐aGVHD patients treated with basiliximab in a real‐world setting. Nine hundred forty were recruited from 36 hospitals China, 3683 doses administered. Basiliximab was used as monotherapy ( n = 642) or combination...
This study investigated the static and dynamic characteristics of pupillary light reflex (PLR) in alert rhesus monkey. Temporal PLR were with Maxwellian viewing during sinusoidal changes illumination a 36° stimulus both monkeys humans. Bode plots response fitted by linear model composed delay combined cascaded first- second-order filter. The magnitude conformed to this sharp roll-off above 1.3 Hz for human 1.9 monkey PLR. phase angle 280 ms humans 160 monkeys. To investigate influence...
Epidemiological studies have shown that estrogens protective effects in cardiovascular diseases, even though the results from human clinical trials remain controversial, while most of animal experiments confirmed this effect, but detailed mechanism remains unclear. In study, we found estradiol (E2) treatment significantly increases expression mitochondrial superoxide dismutase (SOD2) mice and vitro aorta endothelial cells. Further investigation shows E2 up-regulates SOD2 through tethering...
Background Increasing evidence has elucidated the clinical significance of tumor infiltrating immune cells in predicting outcomes and therapeutic efficacy. In this study, we comprehensively analyze microenvironment (TME) cell infiltrations clear renal carcinoma (ccRCC) correlated infiltration patterns with anti-tumor immunity outcomes. Methods We analyzed four independent cohorts, including KIRC cohort 533 patients, Zhongshan ccRCC cohorts 259 fresh sample 20 patients metastatic 87 patients....
BackgroundNeoadjuvant chemoimmunotherapy has offered novel therapeutic options for patients with locally advanced oesophageal squamous cell carcinoma (ESCC). Depicting the landscape of genomic and immune profiles is critical in predicting responses.MethodsWe integrated whole-exome sequencing, single-cell RNA immunofluorescence data ESCC samples from 24 who received neoadjuvant treatment PD-1 inhibitors plus paclitaxel platinum-based chemotherapy to identify correlations responses.FindingsAn...
Background/Aims: Liver is a vital organ and retains its regeneration capability throughout adulthood, which requires contributions from different cell populations, including liver precursors intrahepatic stem cells. To overcome the mortality of hepatic progenitors (iHPs) in vitro, we aim to establish reversibly immortalized progenitor cells mouse embryonic liver. Methods Results: Using retroviral system stably express SV40 T antigen flanked with Cre/LoxP sites, repertoire iHP clones varied...
SIRT1 has many important molecular functions in aging, and the estrogen receptors (ERs) have a vasculoprotective effect, although detailed mechanism for roles of ERs vascular aging remains unclear. We found that ERβ expression endothelium was reduced mice, ERα did not change, while activity declined. Further investigation showed regulated by through complexes SIRT1-PPARγ/RXR-p300 bind to PPRE (PPAR response element) site on promoter, declined function mice due compromised phosphorylation at...
Extranodal nasal-type natural killer/T-cell lymphoma (ENKTL) is an Epstein-Barr virus (EBV) associated that progresses rapidly and relapses frequently. Advanced ENKTL multidrug chemoresistant has a poor prognosis. In this study, we aim to develop novel hexokinase domain component 1 (HKDC1)-based antitumor target for involved with the antimetabolic signaling pathway, EBV replication, P-glycoprotein (P-gp) expression. We showed HKDC1 highly upregulated in cells knockdown significantly...
Abstract Background Patients with relapsed or refractory acute myeloid leukemia (R/R AML) and FLT3 ‐internal tandem duplication ( FLT3‐ITD ) respond infrequently to salvage chemotherapy. Objective To investigate the efficacy of sorafenib plus triplet therapy venetoclax, azacitidine, homoharringtonine (VAH) as a in this population. Methods This multicenter, single‐arm, phase 2 study was conducted at 12 hospitals across China. Eligible patients had R/R AML (aged 18–65 years) who were treated...
<p>Supplementary Figure S4. Survival outcomes in VA and VAH patients depending on FLT3-ITD mutation.</p>
<p>Supplementary Figure S5. Incorporating HHT to overcome VEN resistance.</p>
<div>AbstractPurpose:<p>We investigated whether homoharringtonine (HHT) added to venetoclax plus azacitidine (VA) could improve outcomes and counteract the negative effects of genetic patterns in patients with relapsed/refractory acute myeloid leukemia (RR-AML).</p>Experimental Design:<p>A multicenter retrospective cohort study response VA HHT (VAH) versus regimens as salvage treatment RR-AML was performed. The endpoints were rates composite complete remission,...