A5101719352- melanin and skin pigmentation
- Cancer and Skin Lesions
- Cutaneous Melanoma Detection and Management
- Vascular Malformations and Hemangiomas
- Nonmelanoma Skin Cancer Studies
- Cutaneous lymphoproliferative disorders research
- Vascular Tumors and Angiosarcomas
- Monoclonal and Polyclonal Antibodies Research
- Genetic and rare skin diseases.
- Immunotherapy and Immune Responses
- Melanoma and MAPK Pathways
- Atherosclerosis and Cardiovascular Diseases
- Psoriasis: Treatment and Pathogenesis
- Dermatologic Treatments and Research
- Glycosylation and Glycoproteins Research
- Nail Diseases and Treatments
- Immune Cell Function and Interaction
- Photodynamic Therapy Research Studies
- Acne and Rosacea Treatments and Effects
- Infectious Diseases and Mycology
- T-cell and B-cell Immunology
- Dermatology and Skin Diseases
- Tumors and Oncological Cases
- Lymphoma Diagnosis and Treatment
- Laser Applications in Dentistry and Medicine
Air Force Medical University
2016-2025
Xijing Hospital
2016-2025
Beijing Anzhen Hospital
2025
Capital Medical University
2025
Harbin Institute of Technology
2022
Zhejiang Chinese Medical University
2022
Kingston Health Sciences Centre
2020
New York Proton Center
2020
Hannover Re (Germany)
2020
Harbin University
2020
In vitiligo, melanocytes are particularly vulnerable to oxidative stress owing the pro-oxidant state generated during melanin synthesis and genetic antioxidant defects. Autophagy is a controlled self-digestion process which can protect cells against damage. However, exact role of autophagy in vitiligo response mechanism involved still not clear. To determine implications for melanocyte survival stress, we first detected autophagic flux normal exposure H2O2, found that was significantly...
Background and Objectives Photodynamic therapy (PDT) has shown potentially beneficial results in treating port-wine stain, but its benefit–risk profile remains undefined. This study aimed to evaluate the efficacy safety of PDT conducted with hemoporfin a 532 nm continuous wave laser treat stain clinically. Patients Methods randomized clinical trial was eight hospitals China. Participants were adolescent adult patients (age range: 14–65 years old) stain. During stage 1 (day week 8) all at 3:1...
Abstract Epidermal growth factor receptor ( EGFR ), which is overexpressed in psoriatic lesions, has been proven to contribute the hyperproliferation of keratinocytes psoriasis. Single nucleotide polymorphisms SNP s) involved mi RNA s that can regulate expression could potentially influence development The present study investigated association between a functional rs2910164 miR‐146a and risk psoriasis C hinese H an population. A total 521 patients with 582 healthy controls were recruited...
Alpha-synuclein aggregates (α-synAgg) are pathological hallmarks of Parkinson's disease (PD) and other synucleinopathies that induce microglial activation immune-mediated neurotoxicity, but the molecular mechanisms α-synAgg-induced immune poorly defined. We performed quantitative proteomics by mass spectrometry coupled with PCR, immunohistochemical functional validations studies to define characteristics alpha synuclein mediated activation. In mouse microglia, α-synAgg induced robust...
Myocardial infarction (MI) is caused by myocardial ischemia and hypoxia, which causes irreversible damage to the myocardium seriously endangers human health. Exosomes are small, monolayer-structured extracellular vesicles that transport proteins, lipids, mRNAs, miRNAs between cells. Mesenchymal stem cells (MSCs) can secrete a large number of exosomes play role in many pathophysiological processes. The purpose this paper was investigate exosomal microRNA-338 (miR-338) MI its underlying...
Melanoma is the most lethal form of skin cancer, resulting from malignant transformation epidermal melanocytes. Recent revolutionary progress in targeted therapy and immunotherapy has prominently improved treatment outcome, but survival melanoma patients remains suboptimal. Ferroptosis greatly involved cancer pathogenesis can execute outcome immunotherapy. However, detailed regulatory mechanisms cell ferroptosis remain elusive. Herein, we report that Wnt/β-catenin signaling regulates...
Multiple myeloma (MM) is an incurable hematological malignancy that lacks effective therapeutic interventions. Ferroptosis a newly discovered form of cell death has shown great potential for MM therapy. As proteasome inhibitor and necroptosis inducer, shikonin (SHK) performs dual functions in cells. However, whether SHK inhibits the development via ferroptosis or any other mechanism remains elusive. Here, we provide evidence treatment was capable inducing immunogenic (ICD) MM. The results...
Calreticulin (CRT), a damage-associated molecular pattern molecule, is reported to translocate from endoplasmic reticulum membrane in melanocytes under oxidative stress. To investigate the potential role of CRT pathogenesis vitiligo, we analyzed correlation between and ROS serum lesions detected protein kinase RNA-like ER (PERK) expression vitiligo lesions, studied production mediators unfolded response (UPR) pathway, then tested chemotactic migration CD8+ T cells or CD11c+ CD86+ cells....
Abstract Besides the important pathogenic mechanisms of melanoma, including BRAF-driven and immunosuppressive microenvironment, genomic instability abnormal DNA double-strand breaks (DSB) repair are significant driving forces for its occurrence development. This suggests investigating novel therapeutic strategies from synthetic lethality perspective. Poly (ADP-ribose) polymerase 4 (PARP4) is known to be a member PARP protein family. The low expression PARP4 significantly associated with...
Objective: To observe the clinical efficacy and safety of traditional Chinese medicine (TCM) detoxifying wash in treatment tinea versicolor with gastrointestinal dampness-heat syndrome. Methods: 93 patients were randomly divided into observation group (48 cases) control (45 cases). This study was a single-blind randomized controlled trial. The treated external application wash, while 1% bifonazole solution. Both groups received for 20 days, 10 days as one course. adverse reactions recorded...
Although it is widely believed that non-segmental vitiligo (NSV) results from the autoimmune destruction of melanocytes, a clear understanding defects in immune tolerance, which mediate this uncontrolled self-reactivity, still lacking. In present study, we systemically evaluated circulating regulatory T (Treg) cells, including CD4(+) CD25(+) FoxP3(+) Treg cells and invariant natural killer (iNKT) as well naïve memory CD8(+) their cytokine production, cohort 43 progressive NSV patients with...
Psoriasis is a common autoimmune skin disease, characterized by intense proliferation and abnormal differentiation of keratinocytes. Recently, some miRNAs have been proven to show aberrant expression in psoriasis play role the pathogenesis disease. The aim this study was detect serum miR-369-3p levels patients with confirm their correlation disease severity. regulatory mechanism between TNF-α also investigated. Bioinformatics analysis for target genes performed using multiple prediction...
Balamuthia mandrillaris infection is a rare and fatal disease. We have recorded 28 cases of during the past 20 years. Eighteen patients (64%) were male 10 (36%) female. Patient age ranged from 3 to 74 (mean, 27) locations distributed among 12 Provinces in China. Twenty-seven (96%) lived rural areas, 17 (61%) reported history trauma before appearance skin lesions. All presented with lesions as primary symptom, 16 (57%) developed encephalitis. Histopathology revealed granulomatous changes...
Benvitimod cream, a novel synthetic small molecule, was effective in treating mild-to-moderate plaque psoriasis. We conducted phase III clinical trial to assess the efficacy and safety of benvitimod cream patients with psoriasis.We randomly assigned 686 (2:1:1) receive 1% 0.005% calcipotriol ointment or placebo twice day for 12 weeks. The primary end points were percentage 75% greater reduction from baseline psoriasis area severity index (PASI 75) score 0 1 static physician's global...
The aim of this work was to evaluate the suitability ethosomes as carriers for topical application triptolide in a rat model erythema.We determined optimal conditions preparing ethosomes, and we measured their vesicle size by laser particle-size analyzer efficiency entrapment ultracentrifugation.The vitro percutaneous permeation triptolide-loaded investigated measuring diffusion across sample skin. To explore transdermal delivery vivo, used which erythema induced rats methyl nicotinate...
Inherited epidermodysplasia verruciformis (EV) is a rare skin disorder characterized by susceptibility to specific types of human papilloma virus (HPV) and strongly associated with carcinomas. Inactivating mutations in EVER1/EVER2 account for most cases EV. However, more phenotypes related but distinct from EV have been reported an immunodeficiency state without mutation, the genetic basis these atypical poorly understood.To identify causative gene responsible three siblings affected...