A5010050501- Cancer and Skin Lesions
- Pineapple and bromelain studies
- Cancer Immunotherapy and Biomarkers
- Nonmelanoma Skin Cancer Studies
- Dermatological and Skeletal Disorders
- Autoimmune Bullous Skin Diseases
- Genetic and rare skin diseases.
- Nail Diseases and Treatments
- Ferroptosis and cancer prognosis
- Immune Cell Function and Interaction
- Cutaneous Melanoma Detection and Management
- Dermatology and Skin Diseases
- Cutaneous lymphoproliferative disorders research
- Immunotherapy and Immune Responses
- Psoriasis: Treatment and Pathogenesis
- Tumors and Oncological Cases
- Viral-associated cancers and disorders
- Melanoma and MAPK Pathways
- Autoimmune and Inflammatory Disorders
- Cancer-related molecular mechanisms research
- Hedgehog Signaling Pathway Studies
- PI3K/AKT/mTOR signaling in cancer
- Histiocytic Disorders and Treatments
- Skin and Cellular Biology Research
- Skin Diseases and Diabetes
Shanghai Skin Disease Hospital
2016-2025
Tongji University
2016-2025
Anhui Medical University
2020-2025
China Agricultural University
2024-2025
Peking University Cancer Hospital
2024
Peking University
2024
Ministry of Agriculture and Rural Affairs
2024
Shanghai Medical College of Fudan University
2024
National Engineering Research Center for Information Technology in Agriculture
2024
Guangxi Academy of Agricultural Science
2020-2023
RNA sequencing (RNA-seq) is one of the most widely used technologies in transcriptomics as it can reveal relationship between genetic alteration and complex biological processes has great value diagnostics, prognostics, therapeutics tumors. Differential analysis RNA-seq data crucial to identify aberrant transcriptions, limma, EdgeR DESeq2 are efficient tools for differential analysis. However, requires certain skills with R language ability choose an appropriate method, which lacking...
RNA sequencing (RNA-seq) is one of the most widely used technologies in transcriptomics as it can reveal relationship between genetic alteration and complex biological processes has great value diagnostics, prognostics, therapeutics tumors. Differential analysis RNA-seq data crucial to identify aberrant transcriptions, limma, EdgeR DESeq2 are efficient tools for differential analysis. However, requires certain skills with R language ability choose an appropriate method, which lacking...
Metastasis is the most lethal stage of cancer progression. The present study aimed to investigate underlying molecular mechanisms melanoma metastasis using bioinformatics. Using microarray dataset GSE8401 from Gene Expression Omnibus database, which included 52 biopsy specimens patients with and 31 primary melanoma, differentially expressed genes (DEGs) were identified, subsequent data preprocessing affy package, followed by Ontology Kyoto Encyclopedia Genes Genomes (KEGG) pathway enrichment...
Passion fruit (Passiflora edulis Sims) can be divided into yellow and purple varieties. However, information about coloration quality between the two varieties is limited. To reveal underlying mechanism of color formation in this fruit, a combined analysis metabolome transcriptome was conducted study. The results showed that most evaluated flavonols, anthocyanins, flavanols were significantly upregulated compared to their levels fruit. Flavonoid flavonoid carbonoside accumulation markedly...
Deoxynivalenol (DON) is a common mycotoxic contaminant, frequently found in food and feed, causing severe threat to human animal health. Because of the widespread contamination DON, humans involved agricultural practices may be directly exposed DON through skin route. Chlorogenic acid (CGA) phenolic acid, which has anti-inflammatory antioxidant properties. However, it still unclear whether CGA can protect against DON-induced damage. Here, effect on mitigating damage keratinocytes (HaCaT)...
BackgroundClinical appearance and high-frequency ultrasound (HFUS) are indispensable for diagnosing skin diseases by providing internal external information. However, their complex combination brings challenges primary care physicians dermatologists. Thus, we developed a deep multimodal fusion network (DMFN) model combining analysis of clinical close-up HFUS images binary multiclass classification in diseases.MethodsBetween Jan 10, 2017, Dec 31, 2020, the DMFN was trained validated using...
The plant-specific transcription factor gene family, YABBY, belongs to the subfamily of zinc finger protein superfamily and plays an essential regulatory role in lateral organ development. In this study, nine YABBY genes were identified pineapple genome. Seven them located on seven different chromosomes remaining two scaffold 1235. Through structure prediction multiple sequence alignment, we found that AcYABBY3, AcYABBY5 AcYABBY7 lack a C2 their N-terminal C2C2 structure. Analysis cis-acting...
Abstract Proper flower development is essential for sexual reproductive success and the setting of fruits seeds. The availability a high quality genome sequence pineapple makes it an excellent model studying fruit floral organ development. In this study, we sequenced 27 different samples integrated nine published RNA-seq datasets to generate tissue- stage-specific transcriptomic profiles. Pairwise comparisons weighted gene co-expression network analysis successfully identified ovule-,...
Calcium-dependent protein kinase (CPK) is one of the main Ca2+ combined that play significant roles in plant growth, development and response to multiple stresses. Despite an important member stress responsive gene family, little known about evolutionary history expression patterns CPK genes pineapple.Herein, we identified characterized 17 AcoCPK from pineapple genome, which were unevenly distributed across eight chromosomes. Based on structure phylogenetic tree analyses, AcoCPKs divided...
Psoriasis is characterized by keratinocyte proliferation and immune cell infiltration. M2 isoform of pyruvate kinase (PKM2) was reported to have an important role in proliferation, which a rate-limiting enzyme that regulates the final step glycolysis. However, how PKM2 metabolism psoriatic keratinocytes still poorly understood. Interestingly, we found highly expressed epidermis from patients mouse models. overexpression promoted glycolytic while knockdown inhibited Mice lacking specifically...
Background: Diosmetin (DIOS) is a naturally abundant flavonoid and possesses various biological activities that hold promise as an anti-cancer agent. However, the underlying mechanism of DIOS on cutaneous melanoma remain unclear. Objective: This study seeks to explore anti-tumor effect in melanoma. Methods: Here, variety vitro vivo experiments, combined with RNA sequencing (RNA-seq), were employed ascertain potential anti-cutaneous capacity DIOS. Results: The results demonstrated...
Background: Congenital erythropoietic porphyria (CEP, OMIM #263700) is a rare autosomal recessive disease characterized by skin photosensitivity, hypertrichosis, scarring in light-exposed areas, erythrodontia, and dark-reddish urine. The severity of the clinical phenotype directly associated with complete loss enzymatic activity resulting from UROS mutations. Methods: To understand genetic etiology CEP 9-year-old female proband, we checked data collected peripheral blood samples her parents....
Abstract Objectives To investigate the effect of a Chinese traditional medicine, gambogic acid (GA), on human malignant melanoma (MM) A375 cells and to study mechanism apoptosis induced by GA. Methods were treated with GA at different doses for times, their proliferation viability detected 3‐[4,5‐dimethylthiazol‐2‐yl]‐2,5‐diphenyltetrazolium bromide (MTT) assay. Apoptosis in was observed annexin‐V/propidium iodide doubling staining flow cytometry assay Hoechst staining. further determine...
Glioblastoma multiforme (GBM) is the most common and aggressive primary brain cancer, with a median survival of less than 2 years after diagnosis. The tumor microenvironment plays critical role in invasion progression. Microglia infiltrating macrophages are abundant immune cells tumor. In present study, we demonstrate that systemic propentofylline (PPF), an atypical methylxanthine central nervous system (CNS) glial modulating anti-inflammatory actions, significantly decreased growth CNS-1...