A5103246595- Angiogenesis and VEGF in Cancer
- Molecular Sensors and Ion Detection
- Pancreatitis Pathology and Treatment
- Nanoparticle-Based Drug Delivery
- Lipid metabolism and biosynthesis
- Advanced Nanomaterials in Catalysis
- Lanthanide and Transition Metal Complexes
- Geochemistry and Elemental Analysis
- Advanced Drug Delivery Systems
- Electrochemical sensors and biosensors
- Curcumin's Biomedical Applications
- Advanced Photocatalysis Techniques
- Diet, Metabolism, and Disease
- Colorectal Cancer Surgical Treatments
- CRISPR and Genetic Engineering
- Bioactive Compounds and Antitumor Agents
- Catalytic C–H Functionalization Methods
- Catalytic Alkyne Reactions
- Macrophage Migration Inhibitory Factor
- Natural Compounds in Disease Treatment
- Mercury impact and mitigation studies
- Acne and Rosacea Treatments and Effects
- Nitric Oxide and Endothelin Effects
- Diabetes Management and Research
- Restless Legs Syndrome Research
Second Military Medical University
2014-2024
Mianyang Central Hospital
2024
Beijing Institute of Petrochemical Technology
2024
Naval University of Engineering
2023-2024
University of Electronic Science and Technology of China
2024
Zhejiang University of Technology
2024
Jiangxi Provincial People's Hospital
2024
University of Jinan
2021-2024
Sichuan University
2013-2022
West China Hospital of Sichuan University
2015-2022
Psoriasis is characterized by keratinocyte proliferation and immune cell infiltration. M2 isoform of pyruvate kinase (PKM2) was reported to have an important role in proliferation, which a rate-limiting enzyme that regulates the final step glycolysis. However, how PKM2 metabolism psoriatic keratinocytes still poorly understood. Interestingly, we found highly expressed epidermis from patients mouse models. overexpression promoted glycolytic while knockdown inhibited Mice lacking specifically...
Multi-walled carbon nanotubes (MWCNTs) mainly induce oxidative stress through the overproduction of reactive oxygen species (ROS), which can lead to cytotoxicity. Celastrol, a plant-derived compound, exert antioxidant effects by reducing ROS production. Our results indicated that exposure MWCNTs decreased cell viability and increased Nrf2 knockdown (kd) led production enhanced MWCNT-induced Keap1-kd attenuated Treatment with celastrol significantly promoted Keap1 protein degradation...
// Xiao-Yu Dai 1,2,* , Li Zhou Xiao-Ru Huang 1 Ping Fu 2 and Hui-Yao Lan Department of Medicine Therapeutics, Ka Shing Institute Health Sciences, Shenzhen Research Institute, The Chinese University Hong Kong, China Division Nephrology, West Hospital Sichuan University, Chengdu, * These authors have contributed equally to this work Correspondence to: Hui Y. Lan, email: Fu, Keywords : chronic aristolochic acid nephropathy, Smad7, renal fibrosis, inflammation Received January 26, 2015 Accepted...
Dao-Chi powder (DCP) has been widely used in the treatment of inflammatory diseases clinical practice traditional Chinese medicine, but not acute pancreatitis (AP). This study aimed to evaluate effect DCP on severe AP (SAP) and SAP-associated intestinal cardiac injuries. To this end, an SAP animal model was established by retrograde injection 3.5% taurocholic acid sodium salt into biliopancreatic ducts rats. Intragastric (9.6 g/kg.BW) administered 12 h after modeling. The pancreas, duodenum,...
A novel pH-response fluorescent probe MP for the detection of mitophagy process via tracing colocalization coeffcients was developed.
Genome-scale CRISPR/Cas9 system has been a democratized gene editing technique and widely used to investigate functions in some biological processes diseases especially cancers. Aiming characterize aberrations assess their effects on cancer, we designed pipeline identify the essential genes for pan-cancer.CRISPR screening data were that collected from published integrated by Robust Rank Aggregation algorithm. Then, hypergeometrics test random walks with restart (RWR) predict additional...
Vascular calcification is recognized as a common complication in some patients, such chronic renal failure. The purpose of this study was to investigate the role sodium thiosulfate (STS) for transdifferentiation human aortic vascular smooth muscle cells into osteoblast-like induced by high-level phosphate. All were divided STS group 1 (treatment with STS) and 2 (culture medium containing high level phosphate). included normal group, phosphate other subgroups based on treatment different...
Added risk portended by diabetes in addition to hypertension has been related an amplification of endothelial dysfunction. β-blockers are widely used for cardiovascular diseases and improve the function compared with a placebo. However, effect on progenitor cells (EPCs) is still unknown. Five (metoprolol, atenolol, propranolol, bisoprolol, nebivolol) were tested EPC functional screening. Metoprolol improved significantly among five was chosen vivo tests STZ induced diabetic mice. Reactive...
Objective . To explore the effect of different‐volume fluid resuscitation (FR) on organ functions in severe acute pancreatitis (SAP) and to elucidate therapeutic mechanism Poria cocos injuries caused by high‐volume FR. Methods 1. Clinical study: retrospective analysis thirty‐one patients about titrated protocol (TFR) occurrence kidney injury (AKI) secondary SAP. 2. Experimental rats ( N = 30) were randomly divided into five groups: sham, model, low‐volume FR (1.5 ml/kg/h), (10 combined with...
Carboxylesterase (CEs), mainly localized in endoplasmic reticulum (ER), are responsible for hydrolyzing compounds containing various ester bonds. They have been closely associated with drug metabolism and cellular homeostasis. Although some CE fluorescent probes developed, there still a lack of that could target to the ER. Here, we developed novel probe CR specific ER anchor monitoring CEs. In CR, p-toluenesulfonamide was chosen precise targeting. A simple acetyl moiety used as response site...
This study tested the hypothesis that endothelium-specific GTP cyclohydrolase I (GTPCH I) overexpression (Tg-GCH) restores age-associated endothelial dysfunction in vivo. Aortic GTPCH expression and serum nitric oxide (NO) release were measured young aged mice. rings from wild-type (WT) mice Tg-GCH suspended for isometric tension recording. A hind limb ischemia model was used to measure blood flow recovery. Aged showed reduced aorta decreased NO levels serum. Compared with WT mice,...
Polarity is a vital element in endoplasmic reticulum (ER) microenvironment, and its variation closely related to many physiological pathological activities of ER, so it necessary trace fluctuations polarity ER. However, most fluorescent probes for detecting dependent on the changes single emission, which could be affected by factors cause false signals. Ratiometric probe with “built-in calibration” can effectively avoid detection errors. Here, we have designed ratiometric HM monitoring ER...
This study examines the potential of UiO-66 and g-C3N4-based composite catalysts for environmental purification pesticide degradation. By integrating zirconium-based metal-organic framework with graphitic carbon nitride (g-C3N4), a Z-type heterojunction structure is created, enhancing photocatalytic degradation phosphorus recovery. The optimal composite, UiO-66/g-C3N4(UG6:4), shows high efficiency in degrading organophosphorus pesticides like DDVP under visible light. catalyst's surface area...
<title>Abstract</title> This study was designed to investigate the toxic response of Sprague Dawley (SD) rats following oral administration different doses silica nanoparticles (SiNPs) for 94 consecutive days, as well recovery after 30 days withdrawal. Rats were orally administered SiNPs at dosages 0, 125, 250, and 500 mg/kg /day once a day continuous days. By end study, there no fatalities in any experimental animals that received orally. Under tested doses, adverse effects related...
<title>Abstract</title> This study examines the potential of UiO-66 and g-C<sub>3</sub>N<sub>4</sub>-based composite catalysts for environmental purification pesticide degradation. By integrating zirconium-based metal-organic framework with graphitic carbon nitride (g-C<sub>3</sub>N<sub>4</sub>), a Z-type heterojunction structure is created, enhancing photocatalytic degradation phosphorus recovery. The optimal composite, UiO-66/g-C<sub>3</sub>N<sub>4</sub>(UG6:4), shows high efficiency in...