A5103185489- Angiogenesis and VEGF in Cancer
- Traditional Chinese Medicine Analysis
- Chromatography in Natural Products
- Metabolomics and Mass Spectrometry Studies
- Phytochemicals and Antioxidant Activities
- Muscle and Compartmental Disorders
- Gout, Hyperuricemia, Uric Acid
- Nitric Oxide and Endothelin Effects
- Carbon and Quantum Dots Applications
- Tissue Engineering and Regenerative Medicine
- Ginseng Biological Effects and Applications
- Alcohol Consumption and Health Effects
- 3D Printing in Biomedical Research
- Neurotransmitter Receptor Influence on Behavior
- Geochemistry and Elemental Analysis
- Radioactive element chemistry and processing
- Plant chemical constituents analysis
- Cardiovascular Health and Disease Prevention
- Biochemical and Molecular Research
- Pharmacological Effects of Natural Compounds
- Tea Polyphenols and Effects
- Cerebrovascular and Carotid Artery Diseases
- Saffron Plant Research Studies
- Nanocluster Synthesis and Applications
- Advanced Nanomaterials in Catalysis
Second Military Medical University
2013-2022
Naval University of Engineering
2022
Nanozymes have shown promising potential in disease treatment owing to the advantages of low-cost, facile fabrication, and high stability. However, highly complex tumor microenvironment (TME) inherent low catalytic activity severely restrict clinical applications nanozymes. Herein, a novel mild hyperthermia-enhanced nanocatalytic therapy platform based on Z-scheme heterojunction nanozymes by depositing N-doped carbon dots (CDs) onto Nb2 C nanosheets is constructed. CD@Nb2 not only display...
Observational studies have linked uric acid (UA) levels and kidney disease to amino homeostasis, but the causal relationship is unclear. This study aims determine if elevated UA affects whether acids mediate this relationship, focusing on links between UA, circulating acids, disease. Methods: utilized Uox-KO mice as a hyperuricemia model, assessed renal injury through blood biochemistry pathology, analyzed serum changes via targeted acidomics, employed Mendelian randomization investigate...
Rhizoma Smilacis Glabrae (RSG) is a well‐known herbal medicine with the homology of and food. In this study, simultaneous chemical fingerprint quantitative analysis bioactive flavonoid components RSG were developed using accelerated solvent extraction high‐performance liquid chromatography coupled ion trap tandem mass spectrometry. The operational parameters including solvent, temperature, static time, solid‐to‐liquid ratio, cycles optimized. Hierarchical cluster analysis, similarity...
Angelica dahurica is a famous functional food and herb. To guarantee quality of A. dahurica, strategy "Q-markers targeted screening" was successfully developed by sufficient extraction compounds the screening qualitative quantitative markers calculated through chemometric methods based fingerprints. Accelerated solvent selected due to its prominent advantages exhibiting maximum yields varieties especially excellent reproducibility (RSD < 1). After extraction, fingerprints dahuricae samples...
Added risk portended by diabetes in addition to hypertension has been related an amplification of endothelial dysfunction. β-blockers are widely used for cardiovascular diseases and improve the function compared with a placebo. However, effect on progenitor cells (EPCs) is still unknown. Five (metoprolol, atenolol, propranolol, bisoprolol, nebivolol) were tested EPC functional screening. Metoprolol improved significantly among five was chosen vivo tests STZ induced diabetic mice. Reactive...
This study tested the hypothesis that endothelium-specific GTP cyclohydrolase I (GTPCH I) overexpression (Tg-GCH) restores age-associated endothelial dysfunction in vivo. Aortic GTPCH expression and serum nitric oxide (NO) release were measured young aged mice. rings from wild-type (WT) mice Tg-GCH suspended for isometric tension recording. A hind limb ischemia model was used to measure blood flow recovery. Aged showed reduced aorta decreased NO levels serum. Compared with WT mice,...
<title>Abstract</title> Background Observational studies have linked uric acid (UA) levels and kidney disease to amino homeostasis, but the causal relationship is unclear. This study aims determine if elevated UA affects whether acids mediate this relationship, focusing on links between UA, circulating acids, disease. Methods: utilized Uox-KO mice as a hyperuricemia model, assessed renal injury through blood biochemistry pathology, analyzed serum changes via targeted acidomics, employed...
Objective To explore risk factors of depression in patients with polycystic ovarian syndrome (PCOS) . Methods 142 diagnosed as PCOS and meeting criterions were collected from Aug. 2013 to Nov. 2016 our hospital. Demographic data, menstrual status, signs, serum hormone levels, treatment recorded. The degree was evaluated by Hamilton Depression scale (HAMD) . They divided into two groups: non-depression group. Univariate χ2 test multivariate logistic regression analysis used for...
This study was designed to evaluate the subchronic toxicity of compound diphenhydramine hydrochloride (DH) and caffeine in Sprague-Dawley (SD) rats beagle dogs. A total 180 SD (15/sex/group) were randomly divided into low-, medium- high-dose groups (51, 102, 204 mg/kg), DH group (60 (144 mg/kg) vehicle control group. Sixty dogs (5/sex/group) (male: 14.20, 28.30, 56.60 mg/kg, female: 5.66, 28.30 16.60 8.30 40.00 20.00 Rats given continuous oral administration for 28 days following a 28-day...
Multiwalled carbon nanotubes (MWCNTs) are currently widely used and expected to be as drug carriers contrast agents in clinical practice. Previous studies mainly focused on their lung toxicity; therefore, effects the vascular endothelium unclear. In this study, a human angiogenesis array was determine effect of MWCNTs expression profile angiogenic factors endothelial cells clarify role growth factor (VEGF) MWCNT-induced cell injury at cellular animal levels. The results indicated that (20–30...