A5004615765- Effects of Radiation Exposure
- Hydrogen's biological and therapeutic effects
- Immune Response and Inflammation
- MicroRNA in disease regulation
- Anesthesia and Neurotoxicity Research
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Radiation Therapy and Dosimetry
- DNA Repair Mechanisms
- Cancer, Hypoxia, and Metabolism
- Biochemical effects in animals
- Cell death mechanisms and regulation
- Blood properties and coagulation
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Cancer-related Molecular Pathways
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- RNA modifications and cancer
- Erythrocyte Function and Pathophysiology
- NF-κB Signaling Pathways
- Neonatal Respiratory Health Research
- RNA Interference and Gene Delivery
- Free Radicals and Antioxidants
- Genomics, phytochemicals, and oxidative stress
- Hematopoietic Stem Cell Transplantation
University of Shanghai for Science and Technology
2024-2025
Naval University of Engineering
2020-2024
Shenyang Agricultural University
2023-2024
Second Military Medical University
2014-2023
Beijing Jishuitan Hospital
2019
Peking University
2014-2019
Hebei Medical University
2018
Peking University People's Hospital
2014-2015
Hebei Agricultural University
2013
Imperial College Healthcare NHS Trust
2011-2012
Due to the intrinsic resistance of many tumors radiotherapy, current methods improve survival cancer patients largely depend on increasing tumor radiosensitivity. It is well-known that miR-200c inhibits epithelial-mesenchymal transition (EMT), and enhances cell chemosensitivity. We sought clarify effects radiosensitization human breast cells. In this study, we found low levels expression correlated with radiotolerance in overexpression could increase radiosensitivity cells by inhibiting...
Abstract Dendritic cells (DCs) play important roles in the initiation and maintenance of immune response. The dysfunction DCs contributes to tumor evasion growth. Here we report our findings on radiation-induced thymic lymphomas up-regulation expression lipoprotein lipase (LPL) fatty acid binding protein (FABP4) level triacylglycerol (TAG) serum after total body irradiation, which contribute lipid accumulation. with high content showed low co-stimulatory molecules DCs-related cytokines were...
Radiation-induced lung injury (RILI) is one of the most common and fatal complications thoracic radiotherapy. It characterized with two main features including early radiation pneumonitis fibrosis in later phase. This study was to investigate potential radioprotective effects polydatin (PD), which shown exert anti-inflammation anti-oxidative capacities other diseases. In this study, we demonstrated that PD-mitigated acute inflammation late caused by irradiation. PD treatment inhibited...
MiR-34a, a direct target of p53, has shown to exert potent anti-proliferative effects.It also been found that miR-34a can be induced by irradiation in vitro and vivo.However, the relationship between radio-sensitivity, its potential diagnostic significance radiation biology, remain unclear.This study differing responses ionizing (IR) young adult mice were related miR-34a.First, we could many organs both mice.However, level was much higher when compared mice.Next, played critical role...
Our recent studies suggest that H2 (hydrogen) has a potential as novel radioprotector without known toxic side effects. The present study was designed to examine the underlying radioprotective mechanism of and its protective role on irradiated germ cells. Produced by Fenton reaction radiolysis H2O, hydroxyl radicals (•OH) were identified free radical species reduced H2. We used microelectrode dynamically detect concentration in vivo, found significantly situ fluorescence intensity...
Background/Aims: Radiation therapy is an important treatment for thoracic cancer; however, side effects accompanied with radiotherapy lead to limited tumor control and a decline in patient quality of life. Among these effects, radiation-induced lung injury (RILI) the most serious common. Hence, effective remedy RILI needed. Mesenchymal stromal cells (MSCs) are multipotent adult stem that have been demonstrated be some disease caused by tissue damage. However, unlike other injuries, received...
Observational studies have linked uric acid (UA) levels and kidney disease to amino homeostasis, but the causal relationship is unclear. This study aims determine if elevated UA affects whether acids mediate this relationship, focusing on links between UA, circulating acids, disease. Methods: utilized Uox-KO mice as a hyperuricemia model, assessed renal injury through blood biochemistry pathology, analyzed serum changes via targeted acidomics, employed Mendelian randomization investigate...
Abstract Neoadjuvant radiotherapy is the standard treatment for locally advanced rectal cancer, but resistance to this therapy remains a significant clinical challenge. Understanding molecular mechanisms of radioresistance and developing strategies enhance radiosensitivity are crucial improving outcomes. This study investigated role PRKCSH in colorectal cancer its underlying mechanisms. Our results demonstrate that upregulated cells following ionizing radiation. Inhibiting sensitized these...
Dysregulation of certain microRNAs (miRNAs) in cancer can promote tumorigenesis, metastasis and invasion. However, the functions targets only a few mammalian miRNAs are known. In particular, that participates radiation induced carcinogenesis target tumor suppressor gene Big-h3 remain undefined. Here this study, using thymic lymphoma model BALB/c mice, we found is down-regulated miR-21 up-regulated tissue samples. We also inverse correlations between protein expression level among different...
Background: MicroRNAs (miRNAs) are small, single-stranded, noncoding RNAs, which usually bind to the 3'-untranslated region of target mRNAs and capable inducing posttranscriptional gene regulation by blocking translation or degrading mRNA. However, expression level miR-23 in radiation induced carcinogenesis is largely unknown. Methods: Radiation thymic lymphoma model BALB/c mice was set up. miR-23a & miR-23b miRNA levels different tissues cells were detected real-time qPCR. miR-23a/b...
Endotoxemia is a life-threatening situation that signifies key challenge in the field of intensive care medicine. Proinflammatory mediators produced by macrophages play role endotoxemia. Gelsolin (GSN) involved process inflammation.IL-6 and TNF-α supernatant were measured with an ELISA kit. NO production was assessed measurement nitrite concentration Griess assay. si-RNA directed against GSN (si-GSN) transfected Lipofectamine.LPS decreased levels GSN. Recombinant inhibited cytokines induced...
Radiation often causes depletion of immunocytes in tissues and blood, which results immunosuppression. Molecular hydrogen (H2) has been shown recent studies to have potential as a safe effective radioprotective agent through scavenging free radicals. This study was designed test the hypothesis that H2 could protect from ionizing radiation (IR).H2 dissolved physiological saline or medium using an apparatus produced by our department. A 2-[6-(4'-hydroxy) phenoxy-3H-xanthen-3-on-9-yl] benzoate...
Dendritic cells (DCs) are the most potent antigen-presenting and play a crucial role in regulation of immune response migration DCs into secondary lymphoid tissues also an important initiation innate adaptive immunity.Radiation therapy is now routine treatment for certain types cancer over 20 percent patients will require radiation during their disease.However, influence ionizing irradiation on migratory ability largely unknown.In this article, we report that ray can significantly inhibit...
As a common serious complication of thoracic radiotherapy, radiation-induced pulmonary fibrosis (RIPF) severely limits radiation therapy approaches. Epithelial–mesenchymal transition (EMT) is direct contributor to the fibroblast pool during fibrogenesis, and prevention EMT considered an effective strategy inhibit tissue fibrosis. Our previous study revealed that TANK-binding kinase 1 (TBK1) regulates in lung cancer cells. In present study, we aimed investigate therapeutic potential targeting...
Abstract Background Neoadjuvant radiotherapy has been used as the standard treatment of colorectal cancer (CRC). However, resistance often results in failure. To identify radioresistant genes will provide novel targets for combined treatments and prognostic markers. Methods Through high content screening tissue array from CRC patients who are resistant or sensitive to radiotherapy, we identified a potent gene SUMO specific peptidase 5 (SENP5). Then, effect SENP5 on radiosensitivity was...
Wheat stem rust, caused by the fungus Puccinia graminis f. sp. tritici (Pgt), poses a substantial threat to global wheat production. Utilizing rust resistance (Sr) genes represents an economically viable, effective, and environmentally friendly approach disease control. In this study, gene postulation, molecular testing, pedigree analysis were used identify presence of Sr in 45 cultivars. addition, these cultivars was evaluated against two predominant Pgt races, 34MRGQM 21C3CTHTM, at...
Ionizing radiation (IR) is a well-known carcinogen, however the mechanism of induced thymic lymphoma not well known.Moreover, an easy and effective method to protect mice from still unknown.Hydrogen, or H 2 , seldom regarded as important agent in medical usage, especially therapeutic gas.Here this study, we found that protects BALB/c mice.
Radiotherapy is an indispensable approach for lung cancer, especially non-small cell cancer (NSCLC) with high incidence and mortality. However, cellular resistance to ionizing radiation often results in failure treatment. In this study, we aimed investigate the role of Sirt3 radiotherapy on NSCLC.