A5052918021- Effects of Radiation Exposure
- Blood properties and coagulation
- DNA Repair Mechanisms
- Erythrocyte Function and Pathophysiology
- Lipid metabolism and disorders
- Radiation Therapy and Dosimetry
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Genetic factors in colorectal cancer
- Radiation Dose and Imaging
- Neuroblastoma Research and Treatments
- Neonatal Respiratory Health Research
- Mycobacterium research and diagnosis
- Circular RNAs in diseases
- PARP inhibition in cancer therapy
- Radioactivity and Radon Measurements
- Management of metastatic bone disease
- Congenital Diaphragmatic Hernia Studies
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- RNA Research and Splicing
- Cancer Research and Treatments
- Cell death mechanisms and regulation
- Hydrogen's biological and therapeutic effects
- Nuclear Physics and Applications
- Lung Cancer Treatments and Mutations
Tongji University
2014-2024
Shanghai Pulmonary Hospital
2014-2024
Second Military Medical University
2019
National Institute for Radiological Protection
2012
Chinese Center For Disease Control and Prevention
2012
As a common serious complication of thoracic radiotherapy, radiation-induced pulmonary fibrosis (RIPF) severely limits radiation therapy approaches. Epithelial–mesenchymal transition (EMT) is direct contributor to the fibroblast pool during fibrogenesis, and prevention EMT considered an effective strategy inhibit tissue fibrosis. Our previous study revealed that TANK-binding kinase 1 (TBK1) regulates in lung cancer cells. In present study, we aimed investigate therapeutic potential targeting...
Abstract Identifying new targets for overcoming radioresistance is crucial improving the efficacy of lung cancer radiotherapy, given that tumor cell resistance a leading cause treatment failure. Recent research has spotlighted significance Musashi2 (MSI2) in biology. In this study, we first demonstrated MSI2 plays key function regulating radiosensitivity cancer. The expression negatively correlated with overall survival patients, and knockdown inhibits tumorigenesis increases cells. Cellular...
Abstract Radiation‐induced lung injury (RILI), divided into early radiation pneumonia (RP) and late radiation‐induced pulmonary fibrosis (RIPF), is a common serious disease after clinical chest radiotherapy or nuclear accident, which seriously threatens the life safety of patients. There has been no effective prevention treatment strategy till now. Epithelial‐mesenchymal transition (EMT) key step in occurrence development RILI. In this study, we demonstrated that emetine dihydrochloride...
The small intestine is one of the most sensitive organs to irradiation injury, and development high effective radioprotectants especially with low toxicity for intestinal radiation sickness urgently needed. Monophosphoryl lipid A (MPLA) was found be radioprotective in our previous study, while its effect against injury remained unknown. In present we firstly determined apoptosis after according TUNEL assay. Subsequently, adopted immunofluorescence technique assess expression levels different...
Abstract Background To block repairs of DNA damages, especially the double strand break (DSB) repair, can be used to induce cancer cell death. DSB repair depends on a sequential activation factors that may potentially targeted for clinical therapy. Up now, many protein components complex remain unclear or poorly characterized. In this study, we discovered Transglutaminase 2 (TG2) acted as new component complex. Methods A bioinformatic analysis was performed identify damage relative genes...
Abstract Radiation‐induced lung injury (RILI) is a serious complication in thoracic tumour radiotherapy. It often occurs clinical chest radiotherapy and acute whole‐body irradiation (WBI) caused by nuclear accidents or weapon attack. Some radioprotective agents have been reported to exert protective effects when given prior radiation exposure, however, there no treatment strategy available for preventing RILI. In this study, we demonstrated that heat‐killed Salmonella typhimurium (HKST),...
Abstract Injury‐induced by ionizing radiation (IR) severely reduces the quality of life victims. The development protectors is regarded as one most resultful strategies to alleviate damages caused IR exposure. In present study, we investigated radioprotective effects agonist nucleotide‐binding‐oligomerization‐domain‐containing proteins 2 called murabutide (MBD) and clarified potential mechanisms. Our results showed that pretreatment with MBD effectively protected cultured cells mice against...
The aim of this work was to develop a method provide rapid results for humans with internal radioactive contamination. authors hypothesized that valuable information could be obtained from gas proportional counter techniques by screening urine samples potentially exposed individuals rapidly. Recommended gross alpha and beta activity methods generally employ counting techniques. Based on International Standards Organization (ISO) methods, improvements were made in the evaporation process...
Gastrointestinal (GI) toxicity caused by ionizing radiation (IR) is a dose limiting factor in radiotherapy and great threat for individual nuclear-related military missions. However, there are currently no available strategies to effectively prevent the damage on intestine induced IR. In present study, protective activity of Heat Killed Salmonella typhimurium (HKST) against IR was investigated. Through mouse intestinal organoids whole body irradiation mice, we found that pretreatment with...
Objective To investigate the expressions of lung cancer related genes and miRNA in peripheral blood residents surrounding extremely high radon hot springs Ruoergai County,Sichuan Province. Methods Peripheral samples were collected from local residents.Expressions (p53,k-ras) (let-7a,miR-34a/b) detected by real-time PCR protein p53 k-ras Western blot.Results The mRNA area 0.97 1.33 times control respectively (t =0.13,-1.12,P ＞0.05),and levels 0.70 1.23 =0.72,0.46,P ＞ 0.05).The let-7a was...