A5100374791- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Autophagy in Disease and Therapy
- Epigenetics and DNA Methylation
- Cancer-related Molecular Pathways
- Effects of Radiation Exposure
- Gastric Cancer Management and Outcomes
- Drug Transport and Resistance Mechanisms
- Hematopoietic Stem Cell Transplantation
- Cancer-related gene regulation
- Cancer, Hypoxia, and Metabolism
- Urinary Bladder and Prostate Research
- RNA Research and Splicing
- Glioma Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Endoplasmic Reticulum Stress and Disease
- Pancreatic and Hepatic Oncology Research
- Vanadium and Halogenation Chemistry
- Cancer Research and Treatments
- Acute Ischemic Stroke Management
Wenzhou Medical University
2018-2025
Qingdao University
2016-2025
Affiliated Hospital of Qingdao University
2016-2025
Donghua University
2020-2025
Beijing Forestry University
2025
Chinese University of Hong Kong
2022-2024
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
2024
Zigong First People's Hospital
2022-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2024
Tianjin Medical University Cancer Institute and Hospital
2014-2024
We investigated the relation between computed tomography measures of aortic calcification and values for bone density number fragility fractures in 2348 healthy, postmenopausal women. To determine whether increases vascular loss progress parallel, baseline were compared with measurements obtained 9 months to 8 yr later a subgroup 228 Of subjects studied, 70% had osteoporosis, 30% at least one vertebral fracture, 9% hip fracture. Aortic calcifications inversely related directly fractures....
The aims of the present study are to determine miRNA expression signature in rat hearts after ischaemic preconditioning (IP) and identify an IP-regulated miRNA, miR-21, IP-mediated cardiac protection, potential cellular molecular mechanisms involved. was investigated hearts. Among 341 arrayed miRNAs, 40 miRNAs were differentially expressed (21 up 19 down) with IP, compared their controls. Some these further verified by quantitative reverse transcriptase–polymerase chain reaction. Remarkably,...
Sexual reproduction requires the specification of cells with distinct fates in plants and animals. The EMS1 (also known as EXS) leucine-rich repeat receptor-like kinase (LRR-RLK) TPD1 small protein play key roles regulating somatic reproductive cell fate determination Arabidopsis anthers. Here, we show that ectopic expression causes abnormal differentiation In addition, activity functional EMS1. Yeast two-hybrid, pull-down, coimmunoprecipitation analyses further demonstrate interacts vitro...
The inhibition of mild steel corrosion in 1.0 M HCl solution by quinoxaline and its derivatives were evaluated at 25 °C using weight loss measurement Tafel polarization technique. These measurements reveal that the efficiency increased with increase concentrations inhibitors, efficiencies decrease order 4-(quinoxalin-2-yl)phenol (PHQX) > 2-quinoxalinethiol (THQX) 2-chloroquinoxaline (CHQX) (QX). curves show all investigated inhibitors act as mixed-type inhibitors. Quantum chemical...
<h3>Background</h3> Despite advances in bowel preparation methods, the quality of some patients undergoing colonoscopy remains unsatisfactory. The effect telephone re-education (TRE) on day before and other outcome measures had not been studied. <h3>Methods</h3> A prospective colonoscopist-blinded study was conducted. All received regular instructions during a visit to discuss colonoscopy. Those scheduled for were randomly assigned receive TRE (TRE group) or no (control group). primary rate...
To determine the epidemiology of coronavirus disease (COVID-19) in a remote region China, far from Wuhan, we analyzed COVID-19 Gansu Province. From January 23 through February 3, 2020, total 35 (64.8%) 54 reported cases were imported COVID-19-epidemic areas. Characteristics that differed significantly during first and second waves illness Province mean patient age, occupation, having visited epidemic areas, mode transportation. Time infection to onset for family clusters was shorter than...
Recent evidence has suggested that long non-coding RNAs (lncRNAs) may play a significant role in the pathogenesis of several neurological diseases, including spinal cord injury (SCI). However, little is known about lncRNAs SCI. The aim present study was to evaluate potential functions SCI and identify underlying mechanisms action. We firstly analyzed Gene Expression Omnibus (GEO) datasets investigate aberrantly-expressed which might be involved RNA X-inactive specific transcript (XIST) found...
Visceral leishmaniasis is responsible for up to 30,000 deaths every year. Current treatments have shortcomings that include toxicity and variable efficacy across endemic regions. Previously, we reported the discovery of GNF6702, a selective inhibitor kinetoplastid proteasome, which cleared parasites in murine models leishmaniasis, Chagas disease, human African trypanosomiasis. Here, describe characterization LXE408, structurally related kinetoplastid-selective proteasome currently Phase 1...
Farnesoid X receptor (FXR) agonists are emerging as important potential therapeutics for the treatment of nonalcoholic steatohepatitis (NASH) patients, they exert positive effects on multiple aspects disease. FXR reduce lipid accumulation in liver, hepatocellular inflammation, hepatic injury, and fibrosis. While there currently no approved therapies NASH, bile acid-derived agonist obeticholic acid (OCA; 6-ethyl chenodeoxycholic acid) has shown promise clinical studies. Previously, we...
Progression to a castration resistance state is the main cause of deaths in prostate cancer (PCa) patients. Androgen Receptor (AR) signaling plays central role progression Castration Resistant Prostate Cancer (CRPC), therefore understanding mechanisms AR activation milieu low androgen critical discover novel approach treat CRPC.Firstly, we explore CRPC associated lncRNAs by transcriptome microarray. The expression and clinical features lnc-LBCS are analyzed three independent large-scale...
As one kind of high nutrition fruits, abandoned Myrica rubra causes great waste due to short storage period. For resource utilization, we herein fabricated the rubra-based N-doped carbon dots (MN-CDs) by a facile/green hydrothermal method. MN-CDs, from four regions China, displayed significant differences in their corresponding fluorescence intensities (FIs). Interestingly, different batches waxberry samples same region (Wenzhou, China) exhibited slight FIs, and also an excellent...
Importance Previous studies suggested a benefit of argatroban plus alteplase (recombinant tissue-type plasminogen activator) in patients with acute ischemic stroke (AIS). However, robust evidence trials large sample sizes is lacking. Objective To assess the efficacy for AIS. Design, Setting, and Participants This multicenter, open-label, blinded end point randomized clinical trial including 808 AIS was conducted at 50 hospitals China enrollment from January 18, 2019, through October 30,...
The expression of heat shock genes is controlled at the level transcription by members factor family in vertebrates. HSF4 a mammalian characterized its lack suppression domain that modulates formation DNA-binding homotrimer. Here, we have determined exon structure human <i>HSF4</i> gene and identified major new isoform, HSF4b, derived alternative RNA splicing events, addition to previously reported HSF4a isoform. In mouse tissues HSF4b mRNA was more abundant than as examined reverse...
New pH-activatable ratiometric fluorescent probes have been developed that a coumarin structure attached to benzothiazole or indole units with one two conjugated bonds. They optical responses in acidic conditions. Probes (1) and (2, 3) opposite changes pH, terms of shifts absorption emission. Quantum chemical calculations the B3LYP exchange functional provide insights into differences properties between 1 2/3. Probe 3...
An organocatalytic enantioselective addition of oxazolones to N-tosyl aldimines has been developed. The process is promoted by a readily prepared cinchona alkaloid ligand and affords series valuable α-disubstituted α,β-diamino acid derivatives with excellent enantioselectivities (up 97% ee) diastereoselectivities >30:1 dr). adducts can be transformed into the corresponding protected chiral acids one-pot hydrolyzed reaction smoothly.