A5008207706- Diet and metabolism studies
- Colorectal Cancer Surgical Treatments
- Cancer, Hypoxia, and Metabolism
- Cardiovascular Function and Risk Factors
- Bariatric Surgery and Outcomes
- Anorectal Disease Treatments and Outcomes
- Metabolism, Diabetes, and Cancer
- Diabetes Treatment and Management
- Stoma care and complications
- MicroRNA in disease regulation
- Gastric Cancer Management and Outcomes
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Advanced Nanomaterials in Catalysis
- Nanoplatforms for cancer theranostics
- RNA modifications and cancer
- Cardiovascular Disease and Adiposity
- Cancer-related Molecular Pathways
- Minimally Invasive Surgical Techniques
- Biochemical and Molecular Research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Protein Tyrosine Phosphatases
- Signaling Pathways in Disease
- Hearing, Cochlea, Tinnitus, Genetics
- Infective Endocarditis Diagnosis and Management
Kyung Hee University
2025
Qilu Hospital of Shandong University
2018-2024
Shandong Provincial QianFoShan Hospital
2021-2022
Shandong University
2021-2022
Rutgers New Jersey Medical School
2010
The aims of the present study are to determine miRNA expression signature in rat hearts after ischaemic preconditioning (IP) and identify an IP-regulated miRNA, miR-21, IP-mediated cardiac protection, potential cellular molecular mechanisms involved. was investigated hearts. Among 341 arrayed miRNAs, 40 miRNAs were differentially expressed (21 up 19 down) with IP, compared their controls. Some these further verified by quantitative reverse transcriptase–polymerase chain reaction. Remarkably,...
Abstract Background Acquired resistance of 5-fluorouracil (5-FU) remains a clinical challenge in colorectal cancer (CRC), and efforts to develop targeted agents reduce have not yielded success. Metabolic reprogramming is key hallmark confers several tumor phenotypes including chemoresistance. Glucose metabolic events 5-FU CRC has been evaluated, whether abnormal glucose metabolism could impart also poorly defined. Methods Three separate acquired cell line models were generated, was assessed...
Although 5-fluorouracil (5-FU) is the primary chemotherapy treatment for colorectal cancer (CRC), its efficacy limited by drug resistance. Ferroptosis activation a promising 5-FU-resistant cells; however, potential therapeutic targets remain elusive. This study investigated ferroptosis vulnerability and dihydroorotate dehydrogenase (DHODH) activity using stable, CRC cell lines xenograft models. was characterized measuring malondialdehyde levels, assessing lipid metabolism peroxidation,...
Advanced ScienceVolume 12, Issue 6 2570032 Inside Back CoverOpen Access A Novel "Three-in-One" Copper-Based Metal-Organic Framework Nanozyme Eradicates Colorectal Cancer and Overcomes Chemoresistance for Tumor Therapy (Adv. Sci. 6/2025) Shuohui Dong, DongSearch more papers by this authorHaolin Cao, Haolin CaoSearch authorYe Yuan, Ye YuanSearch authorShuo Liang, Shuo LiangSearch authorZhendong Fu, Zhendong FuSearch authorWei Shi, Wei ShiSearch authorQian Xu, Qian XuSearch authorXiang Zhao,...
Background The obesity epidemic has been on the rise due to changes in living standards and lifestyles. To combat this issue, sleeve gastrectomy (SG) emerged as a prominent bariatric surgery technique, offering substantial weight reduction. Nevertheless, mechanisms that underlie SG-related bodyweight loss are not fully understood. Methods In study, we conducted collection of preoperative 3-month postoperative serum fecal samples from patients who underwent laparoscopic SG at First Affiliated...
Background The early mortality after surgery for infective endocarditis is high. Although risk models help identify patients at high risk, most current scoring systems are inaccurate or inconvenient. objective of this study was to construct an accurate and easy‐to‐use prediction model endocarditis. Methods Results A total 476 consecutive with who underwent 2 centers were included. development cohort consisted 276 patients. Eight variables selected from 89 potential predictors as input the...
Noise exposure causes noise-induced hearing loss (NIHL). NIHL exhibits of inner ear sensory hair cells and is often irreparable. Although oxidative stress involved in loss, the complex mechanisms are unclear. Hypoxia-inducible factor 1α (HIF-1α) has been suggested to be essential for protecting cells. Additionally, it shown that ROS modulating stability HIF-1α. To investigate pathogenesis, we established a tert-butyl hydroperoxide (t-BHP)-induced damage model hair-like HEI-OC1 an C57BL/6...
Chemoresistance against 5-fluorouracil (5-FU) is a major issue for colorectal cancer (CRC) patients. Increasing evidence the roles of CD147 in glycolipid metabolic reprogramming and chemoresistance tumor cells has emerged recent years. However, whether contributes to 5-FU resistance CRC role abnormal metabolism this process remain poorly understood. We analyzed expression primary samples patients found that upregulated correlated with decreased chemosensitivity an unfavorable prognosis...
Abstract Despite considerable advancements in the treatment of colorectal cancer (CRC), overall survival rate for patients with advanced CRC remains below 50%, primarily due to challenges posed by drug resistance and metastasis. Here, a novel “Three‐in‐One” Cu‐based metal‐organic framework nanozyme peroxidase‐like (POD‐like) activity has been successfully developed, aiming promote cell death dual targeting oxidative stress copper ion homeostasis, which could via apoptosis cuproptosis,...
Diabetic cardiomyopathy (DCM) is characterized by impaired diastolic and systolic myocardial performance a major cause of morbidity mortality in patients with diabetes. Surgical bariatric procedures, such as sleeve gastrectomy (SG), result remission type 2 diabetes (T2DM) have benefits function. Maintaining cardiac mitochondrial homeostasis promising therapeutic strategy for DCM. However, whether SG surgery affects function its underlying mechanism remains unclear. This study aimed to...
BACKGROUND The mechanism of improvement type 2 diabetes after duodenal-jejunal bypass (DJB) surgery is not clear. AIM To study the morphological and functional changes in adipose tissue DJB explore potential mechanisms contributing to postoperative insulin sensitivity a diabetic male rat model. METHODS sham was performed a-high-fat-diet/streptozotocin-induced All weighed observed under microscope. Use inguinal fat represent subcutaneous (SAT) mesangial visceral tissue. RNA-sequencing...
Diabetic cardiomyopathy (DCM) can develop in diabetes mellitus and is a major cause of morbidity mortality. Surgical bariatric surgery procedures, such as sleeve gastrectomy (SG), result remission type 2 have benefits regarding systolic diastolic myocardial function. The NLR family pyrin domain containing 3 (NLRP3) inflammasome appears to participate the development DCM. However, whether SG affects NLRP3 inflammasome-related pyroptosis improve cardiac function remains unclear. This study was...
To introduce a novel, modified primary closure technique of laparoscopic extralevator abdominal perineal excision (LELAPE) for low rectal cancer.We retrospectively analyzed data from 76 patients with cancer who underwent LELAPE March 2013 to May 2016. Patients were classified into the group (32 patients) and biological mesh (44 patients). The total operating time, reconstruction postoperative stay duration, cost, complications tumor recurrence compared.All surgery was successfully performed....
Introduction: While intracorporeal anastomosis (IA) has been widely used in totally laparoscopic right colectomy, its application segmental left colectomy for splenic flexure cancer remains underexplored, particularly large-scale studies with long-term outcomes. This research aims to assess the technical feasibility and oncological efficacy of IA treating colonic carcinoma, drawing insights from both short-term outcomes a retrospective cohort. Materials methods: A analysis was conducted on...
Abstract Background Diabetic cardiomyopathy is a serious complication of obesity with type 2 diabetes and major cause mortality. Metabolic surgery, such as duodenal‐jejunal bypass (DJB), can effectively improve diabetic cardiomyopathy; however, the underlying mechanisms remain elusive. Oxidative stress one pivotal cardiomyopathy. Our objective was to investigate effect potential DJB on oxidative in heart rats. Methods High‐fat diet combined intraperitoneal injection streptozotocin used...
Background: Cardiac hypertrophy as a main pathological manifestation of diabetic cardiomyopathy (DCM), is significant complication diabetes. Bariatric surgery has been proven to relieve DCM; however, whether it can alleviate diabetes-induced cardiac undefined. Methods: Diabetic and obese rats were performed sleeve gastrectomy (SG) after having diabetes for 16weeks. The euthanized 8weeks SG. Metabolic parameters, heart function myocardial glucose uptake, morphometric histological changes, the...
Objective: To investigate the feasibility and safety of air test (AT) methylene blue perfusion (MBPT) to detect quality anastomosis in laparoscopic rectal cancer excision (Dixon), compare two approaches. Methods: AT is performed by filling pelvis with saline solution insufflating rectum through a size 22 G balloon catheter (Foley). MBPT carried out surrounding clean sponges around injecting into as like AT. The connected manometer,ensuring pressure can reach 40 cmH(2)O during MBPT. presence...
Sleeve gastrectomy (SG) is the most widely used bariatric procedures globally, which could improve glucose and lipid metabolism dramatically. Circular RNAs (circRNAs) are being increasingly implicated in numerous pathophysiological processes. However, for diabetes mellitus (DM), expression function of circRNAs remain largely undetermined, particular, whether mediate amelioration DM observed after SG. Using a diabetic rat model, we subjected liver tissue from SG sham-operated rats to RNA...
The title compound, 2-azidoethylammonium 3-nitro-1,2,4-triazol-5-onate, N3CH2CH2NH2+.C2H2N4O3−, is a new salt of 3-nitro-1,2,4-triazol-5-one. triazole ring planar within 0.0067 (5) Å, the nitro group rotated 14.0 (4)° out plane. H atom on anion in position 1.