A5100343168- Bone Tissue Engineering Materials
- Cancer-related molecular mechanisms research
- Graphene and Nanomaterials Applications
- Cancer Cells and Metastasis
- Neonatal Respiratory Health Research
- Dental Implant Techniques and Outcomes
- Circular RNAs in diseases
- Neuroscience of respiration and sleep
- Lung Cancer Treatments and Mutations
- 3D Printing in Biomedical Research
- Nanoplatforms for cancer theranostics
- Ruminant Nutrition and Digestive Physiology
- RNA modifications and cancer
- Laser Material Processing Techniques
- Advanced Sensor and Energy Harvesting Materials
- Brain Metastases and Treatment
- Lung Cancer Research Studies
- Biosensors and Analytical Detection
- Dental materials and restorations
- Hearing, Cochlea, Tinnitus, Genetics
- Epigenetics and DNA Methylation
- Polymer Surface Interaction Studies
- Additive Manufacturing and 3D Printing Technologies
- MicroRNA in disease regulation
- Vestibular and auditory disorders
Second Affiliated Hospital of Dalian Medical University
2018-2025
Gansu Provincial Maternal and Child Health Hospital
2025
Dalian Medical University
2018-2025
Peking University
2016-2025
Dalian University of Technology
2022-2025
National Clinical Research
2024-2025
First Affiliated Hospital of Xinjiang Medical University
2025
Xinjiang Medical University
2025
Xiamen University
2025
University of Michigan
2022-2025
Conductive hydrogels have become one of the most promising materials for skin-like sensors because their excellent biocompatibility and mechanical flexibility. However, limited stretchability, low toughness, fatigue resistance lead to a narrow sensing region insufficient durability hydrogel-based sensors. In this work, an extremely stretchable, highly tough, anti-fatigue conductive nanocomposite hydrogel is prepared by integrating hydrophobic carbon nanotubes (CNTs) into hydrophobically...
Abstract For bone defect repair under co-morbidity conditions, the use of biomaterials that can be non-invasively regulated is highly desirable to avoid further complications and promote osteogenesis. However, it remains a formidable challenge in clinical applications achieve efficient osteogenesis with stimuli-responsive materials. Here, we develop polarized CoFe 2 O 4 @BaTiO 3 /poly(vinylidene fluoridetrifluoroethylene) [P(VDF-TrFE)] core-shell particle-incorporated composite membranes...
Brain metastasis (BM) is a leading cause of mortality in patients with non-small cell lung cancer (NSCLC). However, the molecular mechanisms underlying BM NSCLC remain largely unknown because lack models to accurately investigate such dynamic and complex process. Here we developed multi-organ microfluidic chip as new methodological platform study BM. The consisted two bionic organ units – an upstream “lung” downstream “brain” characterized by functional “blood–brain barrier (BBB)” structure,...
ZnO incorporated Ti samples inhibited the expression of <italic>Streptococcus mutans</italic> bacterial adhesion genes and also <italic>P. gingivalis</italic> proliferation. (a) <italic>S. (b) on sample TNT–Zn0.075.
Abstract Radiotherapy, chemotherapy, autologous/allogeneic stem cell transplantation, and targeted drug therapy are currently available therapeutic options for multiple myeloma (MM), but the clinical outcome remains unsatisfactory owing to frequent occurrence of resistance. Anti apoptosis is one main mechanisms mediate Studies have shown that MCL-1 plays a key role in growth cancer cells “escaping” attacks, underlying mechanism unclear. Our previous study demonstrated lncRNA H19 was highly...
Abstract Bioelectricity plays a vital role in living organisms. Although electrical stimulation is introduced the field of bone regeneration, concept dose–response relationship between surface potential and osteogenesis not thoroughly studied. To optimize osteogenic properties different potentials, flexible piezoelectric membrane, poly(vinylidene fluoridetrifluoroethylene) [P(VDF‐TrFE)], fabricated by annealing treatment to control its β phases. The coefficients ( d 33 ) membranes can be...
Abstract Background Platinum‐based chemotherapy is effective in inducing shrinkage of primary lung cancer lesions; however, it shows finite therapeutic efficacy patients suffering from brain metastasis (BM). The intrinsic changes BM cells, which contribute to the poor results remain unknown. Methods Platinum drug‐sensitivity was assessed by utilizing a preclinical model PC9 adenocarcinoma cells vitro and vivo. High consumption glutathione (GSH) two associated upregulated proteins (GPX4...
Brain metastasis (BM) is common among cases of advanced non-small cell lung cancer (NSCLC) and the leading cause death for these patients. Mesothelin (MSLN), a tumor-associated antigen expressed in many solid tumors, has been reported to be involved progression multiple tumors. However, its potential involvement BM NSCLC underlying mechanism remain unknown. The expression MSLN was validated clinical tissue serum samples using immunohistochemistry enzyme-linked immunosorbent assay. ability...
Previous research focused primarily on static metabolic syndrome (MetS) status, with less discussion the effects of its dynamic changes cardiovascular diseases (CVD), stroke, and all-cause mortality. This study examines impact MetS status these health outcomes. used data from two prospective cohorts: China Longitudinal Study Health Retirement (CHARLS) Wuhan Elderly Examination Center community (WEHECC). was determined using ATP III criteria. Participants were classified based in defined as...
Since implants often fail due to infection and uncontrolled inflammatory responses, we designed an in vitro study investigate the antibacterial anti-inflammatory properties of titanium dioxide nanotubes (TNTs) incorporated with selenium nanoparticles (SeNPs). Selenium incorporation was achieved by reaction sodium selenite (Na2SeO3) glutathione (GSH) under a vacuum presence TNTs. Two types bacteria macrophages were cultured on samples determine their respective properties. The results showed...
Abstract Mimicking the endogenous physical microenvironment is a promising strategy for biomaterial‐mediated tissue regeneration. However, precise control of cues such as electric/magnetic fields within extracellular environments to facilitate regeneration remains formidable challenge. Here, remote tuning magnetoelectric achieved by built‐in CoFe 2 O 4 /poly(vinylidene fluoridetrifluoroethylene) [P(VDF‐TrFE)] membrane effective bone The from nanocomposite membranes promotes osteogenic...
Abstract The repair of bone defects in diabetes remains a major challenge the field biomedicine because disturbance immune homeostasis and susceptibility exposed wounds to bacterial infection. Clinically, immunoregulation by removing excessive reactive oxygen species (ROS) effectively promotes diabetic defect repair. However, aggressive ROS clearance can disrupt homeostasis, making ROS‐mediated polarization M2 macrophages process tissue healing be difficult. Herein, an ultrathin defective...
Abstract Near‐infrared (NIR) responsive smart drug delivery systems could provide efficient osteogenesis through the synergy of heat and drugs. However, such are hampered by an inability to allow supersensitive release mild heat. Here superior is demonstrated using a biocompatible dexamethasone (Dex)‐loaded MXene‐poly( N ‐isopropylacrylamide)‐co‐ ‐(Hydroxymethyl) acrylamide hydrogel capable Dex at ≈42 °C upon NIR irradiation. Furthermore, can significantly promote bone regeneration under...
Abstract Heart failure causes considerable morbidity and mortality worldwide. Clinically applied drugs for the treatment of heart are still severely limited by poor delivery efficiency to off-target consumption. Inspired high inhaled drugs, we present an inhalable cardiac-targeting peptide (CTP)-modified calcium phosphate (CaP) nanoparticle TP-10, a selective inhibitor PDE10A. The CTP modification significantly promotes cardiomyocyte fibroblast targeting during pathological state in male...
Mesenchymal stem cell (MSC) migration determines the healing capacity of bone and is crucial in promoting regeneration. Migration MSCs highly dependent on degradation extracellular matrix by proteolytic enzymes. However, underlying mechanisms how enzymolysis paves way for to migrate from their niche defect area still not fully understood. Here, this study shows that high-temperature requirement A3 (HtrA3) overcomes physical barrier provides anchor points through collagen IV degradation,...
Whole organ culture of the spiral ganglion region is a resourceful model system facilitating manipulation and analysis live sprial neurons (SGNs). Three-dimensional (3D) cultures have been demonstrated to many biomedical applications, but effect 3D in maintaining SGNs structure function explant remains uninvestigated. In this study, we used matrigel encapsulate isolated from neonatal mice. First, optimized concentration for found protected against apoptosis, preserved region, promoted...
Nocardia seriolae , an intracellular gram-positive pathogen, is prone to infecting immunocompromised and surface-damaged fish, causing serious losses the aquaculture industry. Although a previous study has demonstrated that N. infects macrophages, persistence of this bacterium in macrophages not been well characterized. To address gap, we used macrophage cell line RAW264.7, investigate interactions between deciphered survival mechanism seriolae. Confocal light microscopy revealed entered 2...
Abstract Patients who have non‐small cell lung cancer (NSCLC) with epidermal growth factor receptor ( EGFR ) mutations are more prone to brain metastasis (BM) and poor prognosis. Previous studies showed that the tumor microenvironment of BM in these patients is immunosuppressed, as indicated by reduced T‐cell abundance activity, although mechanism this immunosuppression requires further study. This study shows reactive astrocytes play a critical role promoting immune escape from ‐mutated...