A5100329785- Cancer Immunotherapy and Biomarkers
- DNA Repair Mechanisms
- Cancer Cells and Metastasis
- RNA modifications and cancer
- Immune cells in cancer
- Ubiquitin and proteasome pathways
- Immune Cell Function and Interaction
- Cancer-related molecular mechanisms research
- Immunotherapy and Immune Responses
- Cancer-related Molecular Pathways
- Peptidase Inhibition and Analysis
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- Immune Response and Inflammation
- Cancer Research and Treatments
- PARP inhibition in cancer therapy
- Melanoma and MAPK Pathways
- interferon and immune responses
- Liver Disease Diagnosis and Treatment
- Natural Compound Pharmacology Studies
- Acute Myeloid Leukemia Research
- Endoplasmic Reticulum Stress and Disease
- Synthesis of Organic Compounds
- Neuropeptides and Animal Physiology
- T-cell and B-cell Immunology
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2025
Union Hospital
2009-2025
Huazhong University of Science and Technology
2009-2025
Hunan University
2023-2025
Second Affiliated Hospital of Nanjing Medical University
2025
Beijing Hospital
2023-2024
Academia Sinica
2023-2024
Bayer (Canada)
2022-2024
Weifang University of Science and Technology
2023-2024
Institute of Hematology & Blood Diseases Hospital
2020-2024
Abstract Several immune suppressive mechanisms that evade the host response have been described in patients with hepatocellular carcinoma (HCC); one of these is expansion myeloid-derived suppressor cells (MDSCs). MDSCs shown to inhibit T cell responses tumor-bearing mice, but little known about humans. Here, we analyzed and characterized effect on innate system, particular, their interaction natural killer (NK) HCC. from HCC inhibited autologous NK cytotoxicity cytokine secretion when...
Abstract Cancer-associated fibroblasts (CAFs) and tumor-associated macrophages (TAMs) are important components of the tumor microenvironment, which have been reported to localize in colorectal carcinomas where they promote progression. One crucial effects exerted is immune-suppression, was recently, however, overall mechanism has not fully addressed. In this study, it shown that TAMs were enriched cancer, their infiltration associated with VCAM-1 expression. Human cancer-derived CAFs can...
Laser photocoagulation, which is the standard treatment for retinopathy of prematurity (ROP), can have adverse events. Studies anti-vascular endothelial growth factor injections suggested efficacy in ROP, but few studies directly compared them with laser treatments.To compare intravitreal aflibercept vs photocoagulation infants ROP requiring treatment.This noninferiority, phase 3, 24-week, randomized clinical trial was conducted 27 countries (64 hospital sites) throughout Asia, Europe, and...
Therapeutic efficacy of carcinoembryonic antigen (CEA)-specific chimeric receptor (CAR) T cells against colorectal cancer (CRC) remains limited due to the unique characteristics and distinct microenvironments tumor tissues. We modified CEA-specific CAR-T cells, aiming stimulate endogenous CD8+ cell responses neoantigens that were derived from CEA-positive tumors destroyed by CAR cells. In a conventional CEA (reg-CAR), we it express lymphotactin XCL1 interleukin (IL)-7 genes, constructing...
Many studies have shown that bio-scaffolds important value for promoting axonal regeneration of injured spinal cord. Indeed, cell transplantation and bio-scaffold implantation are considered to be effective methods neural regeneration. This study was designed fabricate a type three-dimensional collagen/silk fibroin scaffold (3D-CF) with cavities simulate the anatomy normal allows growth in vitro vivo. To observe effects combined stem cells (NSCs) 3D-CF on repair cord injury. Forty...
Summary Pancreatic adenocarcinoma is one of the deadliest cancers with poor survival and limited treatment options. Immunotherapy an attractive option for this cancer that needs to be further developed. Tumours have evolved a variety mechanisms suppress host immune responses. Understanding these responses central in developing immunotherapy protocols. The aim study was investigate potential suppressor might occur during development pancreatic tumours. Myeloid‐derived cells (MDSC) from mice...
Spinal cord injury (SCI) remains the most common cause of paralysis, and there are no effective therapies for SCI patients. Neural stem cell (NSC)-derived exosomes can attenuate apoptosis neuroinflammation after traumatic spinal injury, but mechanisms underlying these effects remain unclear. Here, we examined efficacy miRNAs isolated from as treatments characterized their action. Furthermore, evaluated formed in presence insulin growth factor-1 (IFG-1, IGF-Exo), which promotes neural...
Abstract Homologous recombination (HR) is important for error-free DNA double strand break repair and maintenance of genomic stability. However, upregulated HR also used by cancer cells to promote therapeutic resistance. Therefore, inducing deficiency (HRD) a viable strategy sensitize proficient cancers targeted therapies in order overcome A bromodomain containing protein, BRD9, was previously reported regulate chromatin remodeling transcription. Here, we discover that following damage, the...
N6-methyladenosine (m6A), as the most pervasive internal modification of eukaryotic mRNA, plays a crucial role in various cancers, but its multiple myeloma (MM) pathogenesis has not yet been investigated. In this study, we revealed significantly decreased m6A methylation plasma cells (PCs) from MM patients and showed that abnormal level resulted mainly upregulation demethylase fat mass obesity-associated protein (FTO). Gain- loss-of-function studies demonstrated FTO tumor-promoting...
Importance Prospective long-term data after retinopathy of prematurity (ROP) treatment with anti–vascular endothelial growth factor injections vs laser therapy are scarce. The FIREFLEYE (Aflibercept for ROP IVT Injection Laser Therapy) next trial is prospectively evaluating the efficacy and safety outcomes following intravitreal aflibercept therapy. Objective To evaluate 2-year ophthalmic 0.4-mg injection or in 24-week randomized (2:1) (FIREFLEYE previously reported). Design, Setting,...
Myeloid derived suppressor cells (MDSCs) play a critical role in suppression of immune responses cancer and inflammation. Here, we describe how regulation Bcl2a1 by cytokines controls the function CD11b(+) Gr-1(high) granulocytic MDSCs. Coculture MDSCs with antigen-stimulated T simultaneous blockade IFN-γ use anti-IFN-γ blocking antibody, IFN-γ(-/-) effector cells, IFN-γR(-/-) or STAT1(-/-) led to upregulation improved survival, enhanced their function. Molecular studies revealed that GM-CSF...
Gut microbiota has been identified as a key player in the development of alcoholic liver disease (ALD). Targeting gut with probiotic intervention will be an attractive approach to prevent ALD. Here, we investigated effects Bifidobacterium breve ATCC15700 (ATCC15700) on injury and mice exposed chronic alcohol intake. Our results showed that oral administration significantly decreased endotoxemia, maintained immune homeostasis, alleviated alcohol-induced injury. also promoted intestinal...