A5100610914- PARP inhibition in cancer therapy
- DNA Repair Mechanisms
- Liver Disease Diagnosis and Treatment
- Ubiquitin and proteasome pathways
- Hepatitis B Virus Studies
- Fungal Plant Pathogen Control
- Hepatitis C virus research
- Cancer-related Molecular Pathways
- RNA Research and Splicing
- Liver Disease and Transplantation
- Mitochondrial Function and Pathology
- CRISPR and Genetic Engineering
- Esophageal Cancer Research and Treatment
- RNA modifications and cancer
- Liver Diseases and Immunity
- Endoplasmic Reticulum Stress and Disease
- Microtubule and mitosis dynamics
- Cancer-related gene regulation
- Hepatocellular Carcinoma Treatment and Prognosis
- Acute Ischemic Stroke Management
- Effects of Radiation Exposure
- Gastric Cancer Management and Outcomes
- Cancer, Hypoxia, and Metabolism
- Histone Deacetylase Inhibitors Research
- Protein Degradation and Inhibitors
State Key Laboratory of Digital Medical Engineering
2025
Zhongda Hospital Southeast University
2025
Tongji University
2016-2024
Second Affiliated Hospital of Zhejiang University
2024
Zhejiang University of Science and Technology
2024
Jiangsu Vocational College of Medicine
2024
Shanghai East Hospital
2016-2024
Fujian Agriculture and Forestry University
2024
Second Affiliated Hospital of Fujian Medical University
2021-2023
Fujian Medical University
2021-2023
Clinicians rely upon the severity of liver fibrosis to segregate patients with well-compensated nonalcoholic fatty disease (NAFLD) into subpopulations at high- versus low-risk for eventual liver-related morbidity and mortality. We compared hepatic gene expression profiles in NAFLD identify processes that distinguish two groups hence might be novel biomarkers or treatment targets. Microarray analysis was used characterize percutaneous biopsies from low-risk, “mild” (fibrosis stage 0–1; n =...
<h3>Objective</h3> Immune responses are important in dictating non-alcoholic steatohepatitis (NASH) outcome. We previously reported that upregulation of hedgehog (Hh) and osteopontin (OPN) occurs NASH, Hh-regulated accumulation natural killer T (NKT) cells promotes hepatic stellate cell (HSC) activation, cirrhotic livers harbour large numbers NKT cells. <h3>Design</h3> The hypothesis activated drive fibrogenesis during NASH was evaluated by assessing if depletion protects against fibrosis;...
Liver repair involves phenotypic changes in hepatic stellate cells (HSCs) and reactivation of morphogenic signaling pathways that modulate epithelial-to-mesenchymal/mesenchymal-to-epithelial transitions, such as Notch Hedgehog (Hh). Hh stimulates HSCs to become myofibroblasts (MFs). Recent lineage tracing studies adult mice with injured livers showed some MFs became multipotent progenitors regenerate hepatocytes, cholangiocytes, HSCs. We studied primary HSC cultures two different animal...
BRCA1 regulates multiple cellular pathways that maintain genomic stability including cell cycle checkpoints, DNA repair, protein ubiquitination, chromatin remodelling, transcriptional regulation and apoptosis. Receptor-associated 80 (RAP80) helps recruit to double-strand breaks (DSBs) through the scaffold CCDC98 (Abraxas) facilitates damage response (DDR). However, of RAP80-BRCA1 complex is still unclear. Here we report a deubiquitinase, USP13, DDR by targeting RAP80. Mechanistically, USP13...
Homologous recombination (HR) is one of the major DNA double-strand break (DSB) repair pathways in mammalian cells. Defects HR trigger genomic instability and result cancer predisposition. The defining step homologous strand exchange directed by protein RAD51, which recruited to DSBs BRCA2. However, regulation BRCA2-RAD51 axis remains unclear. Here we report that ubiquitination RAD51 hinders RAD51-BRCA2 interaction, while deubiquitination facilitates binding recruitment thus critical for...
Abstract Homologous recombination (HR) is important for error-free DNA double strand break repair and maintenance of genomic stability. However, upregulated HR also used by cancer cells to promote therapeutic resistance. Therefore, inducing deficiency (HRD) a viable strategy sensitize proficient cancers targeted therapies in order overcome A bromodomain containing protein, BRD9, was previously reported regulate chromatin remodeling transcription. Here, we discover that following damage, the...
Autophagy is an evolutionarily conserved catabolic process, which plays a vital role in removing misfolded proteins and clearing damaged organelles to maintain internal environment homeostasis. Here, we uncovered the checkpoint kinase 2 (CHK2)-FOXK (FOXK1 FOXK2) axis playing important DNA damage-mediated autophagy at transcriptional regulation layer. Mechanistically, following damage, CHK2 phosphorylates FOXK creates 14-3-3γ binding site, which, turn, traps cytoplasm. Because functions as...
Abstract Triple-negative breast cancer (TNBC) treatment remains a great challenge for clinical practice and novel therapeutic strategies are urgently needed. UCHL3 is deubiquitinase that overexpressed in TNBC correlates with poor prognosis. deubiquitinates RAD51 thereby promoting the recruitment of to DNA damage sites augmenting repair. Therefore, overexpression can render cells resistant inducing chemo radiotherapy, targeting sensitize radiation chemotherapy. However, small molecule...
Abstract Objective To elucidate the relationship between USP19 and O(6)‐methylguanine‐DNA methyltransferase (MGMT) after temozolomide treatment in glioblastoma (GBM) patients with chemotherapy resistance. Methods Screening deubiquitinase pannel identifying directly interacts deubiquitination MGMT. Deubiquitination assay to confirm deubiquitinates The colony formation tumor growth study xenograft assess affects GBM sensitive TMZ was performed by T98G, LN18, U251, U87 cell lines....
A large percentage of patients undergoing esophagogastroduodenoscopy (EGD) screening do not have esophageal varices (EV) or only small EV. We evaluated a large, international, multicenter cohort to develop novel score, termed FIB-4plus, by combining the fibrosis-4 (FIB-4) liver stiffness measurement (LSM), and spleen (SSM) identify high-risk EV (HRV) in compensated cirrhosis. This international study involved with cirrhosis from 17 Chinese hospitals one Croatian institution (NCT04546360)....
Abstract The human RecQ helicase BLM is involved in the DNA damage response, metabolism, and genetic stability. Loss of function mutations cause instability/cancer predisposition syndrome Bloom syndrome. However, molecular mechanism underlying regulation cancers remains largely elusive. Here, we demonstrate that deubiquitinating enzyme USP37 interacts with deubiquitinates stabilizes BLM, thereby sustaining response (DDR). Mechanistically, double-strand breaks (DSB) promotes ATM...
Abstract DNA replication stress-mediated activation of the ATR kinase pathway is important for maintaining genomic stability. In this study, we identified a zinc finger protein, ZFP161 that functions as stress response factor in activation. Mechanistically, acts scaffolding protein to facilitate interaction between RPA and ATR/ATRIP. binds ATR/ATRIP through distinct regions stabilizes RPA–ATR–ATRIP complex at stalled forks. This function signaling cascade genome stability maintenance....
Abstract BRCA1-BARD1 heterodimers act in multiple steps during homologous recombination (HR) to ensure the prompt repair of DNA double strand breaks. Dysfunction BRCA1 pathway enhances therapeutic efficiency poly-(ADP-ribose) polymerase inhibitors (PARPi) cancers, but molecular mechanisms underlying this sensitization PARPi are not fully understood. Here, we show that cancer cell sensitivity is promoted by ring between fingers (RBR) protein RNF19A. We demonstrate RNF19A suppresses HR...
Adult tinea capitis is often neglected and misdiagnosed, especially in men. We herein reported an older man with seborrheic dermatitis-like caused by Trichophyton rubrum to raise awareness of the disease. Scale alopecia were critical diagnostic clues this patient. Given previous presence pedis onychomycosis, relevant mycological examinations promptly performed, antifungal therapy, as well patient education, effectively administered.