A5049039248- Epigenetics and DNA Methylation
- Histone Deacetylase Inhibitors Research
- Glioma Diagnosis and Treatment
- Cancer-related gene regulation
- Ocular Oncology and Treatments
Shanghai Ninth People's Hospital
2024
Shanghai Jiao Tong University
2024
Mayo Clinic
2024
Abstract Objective To elucidate the relationship between USP19 and O(6)‐methylguanine‐DNA methyltransferase (MGMT) after temozolomide treatment in glioblastoma (GBM) patients with chemotherapy resistance. Methods Screening deubiquitinase pannel identifying directly interacts deubiquitination MGMT. Deubiquitination assay to confirm deubiquitinates The colony formation tumor growth study xenograft assess affects GBM sensitive TMZ was performed by T98G, LN18, U251, U87 cell lines....