A5082965927- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Diet and metabolism studies
- Nutrition, Genetics, and Disease
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Cancer-related gene regulation
- Gut microbiota and health
- Esophageal Cancer Research and Treatment
- Cancer Immunotherapy and Biomarkers
Second Hospital of Shandong University
2023-2024
Shanxi Medical University
2021
Second Hospital of Shanxi Medical University
2021
The immune system can monitor tumor development, and DNA methylation is involved in the body's response to tumors. In this work, we investigate whether alterations peripheral blood mononuclear cells (PBMCs) could be used as markers for early detection of breast cancer (BC) from perspective alterations. We identify four BC-specific by combining Infinium 850 K BeadChips, pyrosequencing targeted bisulfite sequencing. Based on PBMCs BC, develop an efficient convenient multiplex...
An effective blood-based method for the diagnosis of colorectal cancer has not yet been developed. Molecular alterations immune cells occur early in tumorigenesis, providing theoretical underpinning based on cell profiling. Therefore, we aimed to develop an detection peripheral blood mononuclear (PBMC) improve cancer. Analysis genome-wide methylation landscape PBMCs from patients with and healthy controls by microarray, pyrosequencing, targeted bisulfite sequencing revealed five DNA markers...
Background: Early diagnosis remains an obstacle for improving the outcome of lung adenocarcinoma (LUAD). DNA methylation changes in peripheral blood mononuclear cells (PBMCs) could reflect immune response to tumorigenesis, providing theoretical basis early cancer based on cell profiling. Methods: This multi-center study evaluated patterns PBMCs samples from 1115 individuals at nine medical centers. Genome-wide profiling a discovery cohort (35 LUAD patients and 50 healthy controls) was...
<div>Abstract<p>An effective blood-based method for the diagnosis of colorectal cancer has not yet been developed. Molecular alterations immune cells occur early in tumorigenesis, providing theoretical underpinning based on cell profiling. Therefore, we aimed to develop an detection peripheral blood mononuclear (PBMC) improve cancer. Analysis genome-wide methylation landscape PBMCs from patients with and healthy controls by microarray, pyrosequencing, targeted bisulfite...
<p>Supplementary methods</p>
<p>Supplementary figures</p>
<p>Supplementary methods</p>
<div>Abstract<p>An effective blood-based method for the diagnosis of colorectal cancer has not yet been developed. Molecular alterations immune cells occur early in tumorigenesis, providing theoretical underpinning based on cell profiling. Therefore, we aimed to develop an detection peripheral blood mononuclear (PBMC) improve cancer. Analysis genome-wide methylation landscape PBMCs from patients with and healthy controls by microarray, pyrosequencing, targeted bisulfite...
<p>Supplementary figures</p>