A5100442807- Nanoplatforms for cancer theranostics
- Advanced Fluorescence Microscopy Techniques
- Near-Field Optical Microscopy
- Conducting polymers and applications
- Photoreceptor and optogenetics research
- Photoacoustic and Ultrasonic Imaging
- Immunotherapy and Immune Responses
- Organic Electronics and Photovoltaics
- Integrated Circuits and Semiconductor Failure Analysis
- Advanced Battery Materials and Technologies
- Advanced Nanomaterials in Catalysis
- Advanced biosensing and bioanalysis techniques
- Gold and Silver Nanoparticles Synthesis and Applications
- Cancer Immunotherapy and Biomarkers
- Solid State Laser Technologies
- Advancements in Battery Materials
- Photonic Crystals and Applications
- Nanoparticle-Based Drug Delivery
- Cancer Research and Treatments
- Modular Robots and Swarm Intelligence
- Photonic and Optical Devices
- Soybean genetics and cultivation
- Photodynamic Therapy Research Studies
- Neuroscience and Neural Engineering
- Orbital Angular Momentum in Optics
Stanford University
2018-2025
University of Hong Kong
2023-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2025
Chinese Academy of Fishery Sciences
2023-2025
China National Petroleum Corporation (China)
2025
Ministry of Agriculture and Rural Affairs
2023-2025
Shandong University
2020-2025
Liaocheng University
2020-2025
Liaocheng People's Hospital
2021-2025
Yuntianhua Group (China)
2024-2025
Significance In vivo fluorescence imaging in near IR-IIb window (1,500–1,700 nm) can provide high spatial and temporal resolution deep tissue penetration for fundamental research potential translations. Herein, a bright fluorescent probe emitting at ∼1,600 nm based on lead sulfide (PbS)/CdS quantum dots was developed. The CdS shell helped to chemically passivate retain the of PbS core after phase transfer aqueous solutions biocompatibility. 1,600-nm allowed noninvasive, millimeter-deep...
Metal nanoclusters (NCs) as a new type of fluorescent material have been extensively explored because their attractive set features such ultrafine size, low toxicity, and excellent photostability. However, little progress has made in producing water-soluble, homogeneous, ultrabright metal NCs. In this study, gold NCs (AuNCs) with photoluminescence quantum yield (QY) high 65% are synthesized water through simple blending route. Weak emission is observed from the 6-aza-2-thiothymine-protected...
Abstract Nanoscale correlation of structural information acquisition with specific-molecule identification provides new insight for studying rare subcellular events. To achieve this correlation, scanning electron microscopy has been combined super-resolution fluorescent microscopy, despite its destructivity when acquiring biological structure information. Here we propose time-efficient non-invasive microsphere-based superlens that enables the large-area observation live-cell morphology or...
In the past decade, noticeable progress has been achieved regarding fluorescence imaging in second near-infrared (NIR-II) window. Fluorescence NIR-II window demonstrates superiorities of deep tissue penetration and high spatial temporal resolution, which are beneficial for profiling physiological processes. Meanwhile, molecular emerged as an efficient tool to decipher biological activities on cellular level. Extending into would enhance performance, providing more detailed accurate...
Development of second near-infrared (NIR-II) nanoparticles (NPs) with high biocompatibility, low toxicity, and singlet oxygen quantum yield (ΦΔ) to prevent tumor recurrence is highly desirable in molecular imaging photodynamic/immune combination therapy. Here, theranostic photosensitizer BODIPY (BDP)-I-N-anti-PD-L1 NPs were developed by encapsulating the BDP-I-N amphipathic poly(styrene-co-chloromethylstyrene)-graft-poly(ethylene glycol) nanocarriers through self-assembly functionalization...
Federated learning is an emerging research paradigm enabling collaborative training of machine models among different organizations while keeping data private at each institution. Despite recent progress, there remain fundamental challenges such as the lack convergence and potential for catastrophic forgetting across real-world heterogeneous devices. In this paper, we demonstrate that self-attention-based architectures (e.g., Transformers) are more robust to distribution shifts hence improve...
Therapeutic efficacy of carcinoembryonic antigen (CEA)-specific chimeric receptor (CAR) T cells against colorectal cancer (CRC) remains limited due to the unique characteristics and distinct microenvironments tumor tissues. We modified CEA-specific CAR-T cells, aiming stimulate endogenous CD8+ cell responses neoantigens that were derived from CEA-positive tumors destroyed by CAR cells. In a conventional CEA (reg-CAR), we it express lymphotactin XCL1 interleukin (IL)-7 genes, constructing...
Abstract Fluorescence imaging in the second near‐infrared (NIR‐II) window holds impressive advantages of enhanced penetration depth and improved signal‐to‐noise ratio. Bright NIR‐II fluorophores with renal excretion ability low tissue accumulation are favorable for vivo molecular applications as they can render target‐mediated process easily distinguishable. Here, a probe (anti‐PD‐L1‐BGP6) comprising fluorophore (IR‐BGP6) covalently bonded to programmed cell death ligand‐1 monoclonal...
Recent developments in far-field fluorescent microscopy have enabled nanoscale imaging of biological entities by ingenious applications probes. For non-fluorescence applications, however, scanning probe still remains one the most commonly used methods to "image" features all three dimensions, despite its limited throughput and invasiveness scanned samples. Here, we propose a time-efficient three-dimensional super-resolution method: near-field assisted white light interferometry (NFWLI). This...
Detecting fluorescence in the second near-infrared window (NIR-II) up to ∼1,700 nm has emerged as a novel vivo imaging modality with high spatial and temporal resolution through millimeter tissue depths. Imaging NIR-IIb (1,500-1,700 nm) is most effective one-photon approach suppressing light scattering maximizing penetration depth, but relies on nanoparticle probes such PbS/CdS containing toxic elements. On other hand, NIR-I (700-1,000 or NIR-IIa (1,000-1,300 can be done using biocompatible...
Abstract Sentinel lymph node imaging and biopsy is important to clinical assessment of cancer metastasis, novel non-radioactive lymphographic tracers have been actively pursued over the years. Here, we develop gold molecular clusters (Au 25 ) functionalized by phosphorylcholine (PC) ligands for NIR-II (1000–3000 nm) fluorescence draining nodes in 4T1 murine breast CT26 colon tumor mouse models. The Au-phosphorylcholine (Au-PC) probes exhibit ‘super-stealth’ behavior with little interactions...
Anode-free lithium-metal batteries employ in situ lithium-plated current collectors as negative electrodes to afford optimal mass and volumetric energy densities. The main challenges such include their poor cycling stability the safety issues of flammable organic electrolytes. Here, a high-voltage 4.7 V anode-free battery is reported, which uses Cu foil coated with layer (≈950 nm) silicon-polyacrylonitrile (Si-PAN, 25.5 µg cm-2 ) electrode, cobalt-free LiNi0.5 Mn1.5 O4 (LNMO) positive...
Significance Three-dimensional microscopy in the NIR-II window (1,000 to 1,700 nm) allows noninvasive deep-tissue optical sectioning of live mammals with high spatiotemporal resolution due suppressed light scattering and reduced tissue autofluorescence. Herein, we present a structured-illumination light-sheet (NIR-II SIM) both excitation emission wavelengths NIR-IIb (1,500 nm). Integrating structured illumination into further diminished out-of-focus background improved spatial resolution,...
In vivo fluorescence/luminescence imaging in the near-infrared-IIb (NIR-IIb, 1,500 to 1,700 nm) window under <1,000 nm excitation can afford subcentimeter depth without any tissue autofluorescence, promising high-precision intraoperative navigation clinic. Here, we developed a compact imager for concurrent visible photographic and NIR-II (1,000 3,000 fluorescence preclinical image-guided surgery. Biocompatible erbium-based rare-earth nanoparticles (ErNPs) with bright down-conversion...
Tracking and imaging immune cells in vivo non-invasively would offer insights into the responses induced by vaccination. Here we report a cancer vaccine consisting of polymer-coated NaErF
Surgical resections of solid tumors guided by visual inspection tumor margins have been performed for over a century to treat cancer. Near-infrared (NIR) fluorescence labeling/imaging in the NIR-I (800 900 nm) range with systemically administrated fluorophore/tumor-targeting antibody conjugates introduced improve margin delineation, removal accuracy, and patient survival. Here, we show Au 25 molecular clusters functionalized phosphorylcholine ligands (AuPC, ~2 nm size) as preclinical...
Organic semiconductors (e.g., PCBM and IDIC) frequently serve as interface passivants for perovskite solar cells (PSCs) due to their beneficial passivation effects on interfaces. However, the interiors of films is greatly limited by poor solubility in polar solvents compatibility issues. Here facile synthesis organic semiconductor nanoparticle (NP) that readily disperse inks reported. Adding these NPs into not only modulates crystallization, improves film quality conductivity, but also...