Elizabeth Mellins
A5013648604- Autoimmune and Inflammatory Disorders Research
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Adolescent and Pediatric Healthcare
- Monoclonal and Polyclonal Antibodies Research
- Rheumatoid Arthritis Research and Therapies
- Immunodeficiency and Autoimmune Disorders
- Inflammasome and immune disorders
- vaccines and immunoinformatics approaches
- Diabetes and associated disorders
- Cytomegalovirus and herpesvirus research
- Reproductive System and Pregnancy
- Systemic Lupus Erythematosus Research
- Lymphoma Diagnosis and Treatment
- Celiac Disease Research and Management
- Acute Lymphoblastic Leukemia research
- CAR-T cell therapy research
- Immune cells in cancer
- RNA Interference and Gene Delivery
- Childhood Cancer Survivors' Quality of Life
- Sleep and Wakefulness Research
- Immune responses and vaccinations
- Microscopic Colitis
- Cytokine Signaling Pathways and Interactions
Stanford University
2016-2025
Lucile Packard Children's Hospital
2002-2023
Stanford Health Care
2023
University of Alabama at Birmingham
2017-2022
Pediatrics and Genetics
2006-2021
University of California, San Francisco
2021
Stratford University
2011-2020
Stanford Medicine
1998-2019
Palo Alto University
2006-2019
Case Western Reserve University
2017
Objective Systemic juvenile idiopathic arthritis (JIA) is associated with a recently recognized, albeit poorly defined and characterized, lung disease (LD). The objective of this study was to describe the clinical characteristics, risk factors, histopathologic immunologic features novel inflammatory LD systemic JIA (designated SJIA‐LD). Methods Clinical data collected since 2010 were abstracted from medical records patients Cincinnati Children's Hospital Medical Center. Epidemiologic,...
To investigate the characteristics and risk factors of a novel parenchymal lung disease (LD), increasingly detected in systemic juvenile idiopathic arthritis (sJIA).In multicentre retrospective study, 61 cases were investigated using physician-reported clinical information centralised analyses radiological, pathological genetic data.LD was associated with distinctive features, including acute erythematous clubbing high frequency anaphylactic reactions to interleukin (IL)-6 inhibitor,...
A damaging inflammatory response is implicated in the pathogenesis of severe coronavirus disease 2019 (COVID-19), but mechanisms contributing to this are unclear. In two prospective cohorts, early non-neutralizing, afucosylated immunoglobulin G (IgG) antibodies specific acute respiratory syndrome 2 (SARS-CoV-2) were associated with progression from mild more COVID-19. To study biology IgG immune complexes, we developed an vivo model that revealed human IgG-Fc-gamma receptor (FcγR)...
Systemic juvenile idiopathic arthritis (sJIA) is an often severe, potentially life-threatening childhood inflammatory disease, the pathophysiology of which poorly understood. To determine whether genetic variation within MHC locus on chromosome 6 influences sJIA susceptibility, we performed association study 982 children with and 8,010 healthy control subjects from nine countries. Using meta-analysis directly observed imputed SNP genotypes classic HLA types, identified as a bona fide...
Objectives Juvenile idiopathic arthritis (JIA) is a heterogeneous group of conditions unified by the presence chronic childhood without an identifiable cause. Systemic JIA (sJIA) rare form characterised systemic inflammation. sJIA distinguished from other forms unique clinical features and treatment responses that are similar to autoinflammatory diseases. However, approximately half children with develop destructive, long-standing appears JIA. Using genomic approaches, we sought gain novel...
Monocytes play a critical role in the innate and adaptive immune systems, performing phagocytosis, presenting antigen, producing cytokines. They are heterogeneous population that has been divided humans into classical, intermediate, non-classical subsets, but roles of these subsets incompletely understood. In this study, we investigated expression patterns MHC class II (MHCII) associated molecules find intermediate monocytes express highest levels molecules, HLA-DR (tested n = 30 samples),...
Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe, delayed hypersensitivity (DHR). We observed DRESS to inhibitors of interleukin 1 (IL-1) or IL-6 in small group patients Still's disease atypical lung disease. sought characterise features compared drug-tolerant controls. analysed human leucocyte antigen (HLA) alleles for association inhibitor-related DHR, including Kawasaki (KD) cohort.