A5071385901- Neonatal Respiratory Health Research
- Congenital Diaphragmatic Hernia Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Tracheal and airway disorders
- Medical Imaging and Pathology Studies
- Congenital Heart Disease Studies
- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Transplantation: Methods and Outcomes
- Respiratory Support and Mechanisms
- Neuroscience of respiration and sleep
- Hematopoietic Stem Cell Transplantation
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Lymphatic Disorders and Treatments
- Neonatal Health and Biochemistry
- Innovations in Medical Education
- Cardiac Structural Anomalies and Repair
- Childhood Cancer Survivors' Quality of Life
- Pneumocystis jirovecii pneumonia detection and treatment
- High Altitude and Hypoxia
- Vascular Malformations and Hemangiomas
- Restraint-Related Deaths
- Cystic Fibrosis Research Advances
- Allergic Rhinitis and Sensitization
- Airway Management and Intubation Techniques
University of Washington
2022-2025
University of Colorado Denver
2015-2024
Seattle Children's Hospital
2024
University of Colorado System
2024
Community Medical Center
2023
University of Colorado Anschutz Medical Campus
2018-2023
Children's Hospital Colorado
2015-2023
University of Montana
2022-2023
RELX Group (United States)
2023
Pulmonary Associates
2018-2021
In asthma, airflow obstruction is thought to result primarily from inflammation-triggered airway smooth muscle (ASM) contraction. However, anti-inflammatory and muscle-relaxing treatments are often temporary or ineffective. Overproduction of the mucin MUC5AC an additional disease feature that, while strongly associated pathologically, poorly understood functionally. Here we show that Muc5ac a central effector allergic inflammation required for hyperreactivity (AHR) methacholine (MCh). mice...
To investigate the characteristics and risk factors of a novel parenchymal lung disease (LD), increasingly detected in systemic juvenile idiopathic arthritis (sJIA).In multicentre retrospective study, 61 cases were investigated using physician-reported clinical information centralised analyses radiological, pathological genetic data.LD was associated with distinctive features, including acute erythematous clubbing high frequency anaphylactic reactions to interleukin (IL)-6 inhibitor,...
Children's Interstitial and Diffuse Lung Disease (chILD) is a heterogeneous group of disorders that challenging to categorize. In previous study, classification scheme was successfully applied children 0 2 years age who underwent lung biopsies for chILD. This has not been evaluated in 18 age.This multicenter interdisciplinary study sought describe the spectrum biopsy-proven chILD North America apply previously reported age. Mortality risk factors mortality were also assessed.Patients diffuse...
Childhood interstitial and diffuse lung disease (chILD) encompasses a broad spectrum of rare disorders. The Children's Interstitial Diffuse Lung Disease Research Network (chILDRN) established prospective registry to advance knowledge regarding etiology, phenotype, natural history, management these
Neuroendocrine cell hyperplasia of infancy (NEHI) is an important form children's interstitial and diffuse lung disease for which the diagnostic strategy has evolved. The prevalence comorbidities in NEHI that may influence treatment not been previously assessed.
Summary Introduction Children with chronic respiratory failure and upper airway disorders may require tracheostomy placement long‐term mechanical ventilation, yet many improve to permit ventilator weaning decannulation. Methods As a quality improvement project, we conducted chart review of patients followed by our Ventilator Care Program who underwent evaluation for nocturnal ventilation (NV) and/or decannulation from 2007–2014. We collected patient demographics characterized location,...
Abstract Objectives We sought to describe the phenotype for patients with P.I.G. including presentation, evaluation, cardiac co‐morbidities, high resolution computed tomography findings, and outcomes. Methods With institutional review board approval, we performed a retrospective of biopsy‐proven Biopsies, chest tomography, evaluations were reviewed characterized by experts in each field. Results Sixty‐two percent male. The median gestational age was 37 weeks (range 27‐40). at biopsy 1.6...
Children with single ventricle (SV) heart disease who undergo Fontan operation are at risk for developing multiorgan dysfunction. Although survival has improved, significant comorbidities involving multiple organ systems may develop, requiring evaluation and management by many subspecialists. Using data from an internal survey, we documented high care variability our population. We then developed a multidisciplinary clinic, designed implemented clinical pathway to decrease of patient...
Diffuse villous hyperplasia of the choroid plexus (DVHCP) is a very rare cause hydrocephalus in children. Only 12 cases DVHCP have been reported literature. In this report authors describe new case patient with who was diagnosed prenatally hydrocephalus. comprehensive literature review and discussion, also discuss radiological histological characteristics cases, treatment approaches, surgical modalities that used these patients.
Childhood interstitial and diffuse lung disease (chILD) encompasses a broad spectrum of rare disorders. The Children’s Interstitial Diffuse Lung Disease Research Network (chILDRN) established prospective registry to advance knowledge regarding etiology, phenotype, natural history, management these This longitudinal, observational, multicenter utilizes single-IRB reliance agreements, with participation from 25 chILDRN centers across the U.S. Clinical data are collected managed using...
Liptzin, Deborah R., Steven H. Abman, Ann Giesenhagen, and D. Dunbar Ivy. An approach to children with pulmonary edema at high altitude. High Alt Med Biol. 19:91–98, 2018. Introduction: Diagnosis of high-altitude illness can be more challenging in children, especially those who are preverbal. Families often travel elevations for family vacations, either skiing, hiking, and/or camping. They may present their primary care providers looking anticipatory guidance before or follow-up after...
Therapeutics exist to treat fibrotic lung disease in adults, but these have not been investigated children. Defining biomarkers for pediatric children is crucial clinical trials. Children with surfactant protein C (SFTPC) dysfunction mutations develop over time. We evaluated chest computed tomography (CT) changes time SFTPC mutations.We performed an institutional review board-approved retrospective of mutations. collected demographic and information. Chest CT scans were using visual...
Abstract Objectives Neuroendocrine cell hyperplasia of infancy (NEHI) is a children's interstitial and diffuse lung disease unknown etiology that presents in with characteristic findings tachypnea, retractions, crackles, hypoxemia. At the present, mainstay treatment oxygen supplementation to normalize saturations decrease work breathing. There are pulmonary function, radiographic, histologic findings, but polysomnography (PSG) data has not been reported. We sought report PSG implications for...