A5086014360- Autoimmune and Inflammatory Disorders Research
- Adolescent and Pediatric Healthcare
- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Inflammasome and immune disorders
- Acute Lymphoblastic Leukemia research
- Immunodeficiency and Autoimmune Disorders
- Lymphoma Diagnosis and Treatment
- Kawasaki Disease and Coronary Complications
- Ocular Diseases and Behçet’s Syndrome
- Vitamin D Research Studies
- Childhood Cancer Survivors' Quality of Life
- Systemic Sclerosis and Related Diseases
- Monoclonal and Polyclonal Antibodies Research
- Philosophy, Ethics, and Existentialism
- Family and Disability Support Research
- Spondyloarthritis Studies and Treatments
- Immune Cell Function and Interaction
- Nietzsche, Schopenhauer, and Hegel
- Diabetes and associated disorders
- Atrial Fibrillation Management and Outcomes
- Immunotoxicology and immune responses
- Child and Adolescent Health
- Vitamin C and Antioxidants Research
- Pediatric Pain Management Techniques
New York Medical College
2024-2025
University of Saskatchewan
2013-2023
Royal University Hospital
2005-2019
University of Manitoba
1986-2019
Canadian Institutes of Health Research
2013-2019
Children's Hospital of Eastern Ontario
2017-2019
McGill University Health Centre
2017-2019
Western University
2019
Simon Fraser University
2019
Izaak Walton Killam Health Centre
2019
<h3>Importance</h3> The Choosing Wisely campaign consists of more than 70 lists produced by specialty societies medical practices or procedures minimal clinical benefit to patients in most situations, with recommendations regarding judicious use. <h3>Objective</h3> To quantify the frequency and trends some earliest using nationwide commercial health plan population-level data. <h3>Design, Setting, Participants</h3> Retrospective analysis claims data for members Anthem-affiliated plans....
Acute lower respiratory infection (ALRI) is one of the most common reasons for hospitalization and intensive care unit admission among children. Season related decreases in immunomodulatory molecule, vitamin D, remain an unexplored factor that might contribute to increased occurrence ALRI children.To investigate a possible association between D deficiency by comparing serum 25 hydroxyvitamin [25(OH)D] levels group young children with age-matched without infection.Participants diagnosis...
<h3>Objective</h3> To describe clinical outcomes of juvenile idiopathic arthritis (JIA) in a prospective inception cohort children managed with contemporary treatments. <h3>Methods</h3> Children newly diagnosed JIA at 16 Canadian paediatric rheumatology centres from 2005 to 2010 were included. Kaplan–Meier survival curves for each category used estimate probability ever attaining an active joint count 0, inactive disease (no joints, no extraarticular manifestations and physician global...
Abstract Thirty‐nine children with a syndrome of seronegative enthesopathy and arthropathy were evaluated. The group included 25 patients no apparent underlying primary disease 13 either ankylosing spondylitis, inflammatory bowel disease, reactive arthritis, or Reiter's syndrome. Significant distinguishing characteristics the male predominance, late age at onset, positive family histories oligoarthropathy, axial skeleton involvement, presence B27 histocompatibility antigen. This is...
Severe combined immunodeficiency (SCID) comprises a heterogeneous group of heritable deficiencies humoral and cell-mediated immunity. Many patients with SCID have lymphocyte-activation defects that remain uncharacterized.We performed genetic studies in four patients, from families Northern Cree ancestry, who had clinical characteristics SCID, including early onset severe viral, bacterial, fungal infections despite normal B-cell T-cell counts. Genomewide homozygosity mapping was used to...
Systemic juvenile idiopathic arthritis (sJIA) is an often severe, potentially life-threatening childhood inflammatory disease, the pathophysiology of which poorly understood. To determine whether genetic variation within MHC locus on chromosome 6 influences sJIA susceptibility, we performed association study 982 children with and 8,010 healthy control subjects from nine countries. Using meta-analysis directly observed imputed SNP genotypes classic HLA types, identified as a bona fide...
Objectives Juvenile idiopathic arthritis (JIA) is a heterogeneous group of conditions unified by the presence chronic childhood without an identifiable cause. Systemic JIA (sJIA) rare form characterised systemic inflammation. sJIA distinguished from other forms unique clinical features and treatment responses that are similar to autoinflammatory diseases. However, approximately half children with develop destructive, long-standing appears JIA. Using genomic approaches, we sought gain novel...
BACKGROUND: The use of non-vitamin K oral anticoagulants (NOACs) has increased steadily following marketing approval; however, their relative safety in nonvalvular atrial fibrillation (NVAF) patients real-world clinical practice remains unclear. OBJECTIVE: To compare the risk major bleeding during anticoagulation therapy between warfarin and NOACs. METHODS: This retrospective cohort study analyzed administrative claims data on new NVAF users warfarin, dabigatran, apixaban, or rivaroxaban...
Localized scleroderma (morphea and linear scleroderma) is a connective tissue disease, accompanied by excessive proliferation deposition of collagen within the skin, inflammation, vasculopathy deranged immune system. Interferon gamma (IFNgamma), an inhibitor synthesis immunomodulator, could be potential therapeutic agent if it delivered into or expressed locally in affected skin non-invasive manner. In this study, feasibility topical delivery IFNgamma gene expression were investigated...
Abstract Objective To determine early outcomes and improvements in a prospective inception cohort of children with juvenile idiopathic arthritis (JIA) treated current standard therapies. Methods Patients selected were enrolled an JIA, the Research Arthritis Canadian Children Emphasizing Outcomes Study. The rheumatoid core criteria set measures completed at enrollment 6 months later. Frequencies normal values for each American College Rheumatology (ACR) Pediatric 30, 50, 70 (Pedi 70) response...
<h3>Objective</h3> To describe probabilities and characteristics of disease flares in children with juvenile idiopathic arthritis (JIA) to identify clinical features associated an increased risk flare. <h3>Methods</h3> We studied the Research Arthritis Canadian Children emphasizing Outcomes (ReACCh-Out) prospective inception cohort. A flare was defined as a recurrence manifestations after attaining inactive called significant if it required intensification treatment. Probability first...
Childhood arthritis encompasses a heterogeneous family of diseases. Significant variation in clinical presentation remains despite consensus-driven diagnostic classifications. Developments data analysis provide powerful tools for interrogating large sets. We report novel approach to integrating biologic and toward new classification childhood arthritis, using computational biology data-driven pattern recognition.Probabilistic principal components was used transform set into 4 interpretable...
Juvenile idiopathic arthritis (JIA) comprises 7 heterogeneous categories of chronic childhood arthritides. Approximately 5% children with JIA have rheumatoid factor (RF)-positive arthritis, which phenotypically resembles adult (RA). Our objective was to compare and contrast the genetics RF-positive polyarticular those RA selected other categories, more fully understand pathophysiologic relationships inflammatory arthropathies.Patients (n = 340) controls 14,412) were genotyped using...
Abstract The onset patterns and disease courses of children with juvenile rheumatoid arthritis uveitis were reviewed to establish correlations. Results indicated that although the activity may at times run a parallel course, it is more common for activities be independent.
Insulin binding to insulin receptors, on skin fibroblasts established in culture from an infant with resistance and clinical features of leprechaunism was markedly decreased comparison cultures age-matched control. By contrast, the epidermal growth factor, a polypeptide factor chemically unrelated insulin, patient's control indistinguishable. The selective defect reflected impaired ability stimulate 2-deoxyglucose uptake. These results most likely indicate primary genetic receptors.
This report describes an infant with physical features typical of leprechaunism, including a characteristic facies, hirsutism, and decreased subcutaneous tissue muscle mass. Intermittent hypoglycemia severe hyperinsulinemia were documented. The patient's insulin was normal in molecular size biological activity, but its binding to the cultured fibroblasts profoundly decreased. Insulin antibodies not present. A literature review has been undertaken clarify further clinical, metabolic,...
Objective To describe changes in health‐related quality of life ( HRQ oL) over time children with juvenile idiopathic arthritis JIA ), relative to other outcomes, and identify predictors unfavorable oL trajectories. Methods Children the Research Arthritis Canadian emphasizing Outcomes (Re ACC h‐Out) cohort were included. The Juvenile Quality Life Questionnaire JAQQ , a standardized instrument), My o ML an instrument based on personal valuations), core variables completed serially. Analyses...
To determine whether systemic juvenile idiopathic arthritis (JIA) susceptibility loci that were identified by candidate gene studies demonstrate association with JIA in the largest study population assembled to date.
Background Joint inflammation is the common feature underlying juvenile idiopathic arthritis (JIA). Clinicians recognize patterns of joint involvement currently not part International League Associations for Rheumatology (ILAR) classification. Using unsupervised machine learning, we sought to uncover data-driven that predict clinical phenotype and disease trajectories. Methods findings We analyzed prospectively collected data, including using a standard 71-joint homunculus, 640 discovery...
With modern treatments, the effect of juvenile idiopathic arthritis (JIA) on growth may be less than previously reported. Our objective was to describe height, weight and body mass index (BMI) development in a contemporary JIA inception cohort. Canadian children newly-diagnosed with 2005–2010 had height measurements every 6 months for 2 years, then yearly up 5 years. These were used calculate mean age- sex-standardized Z-scores, estimate prevalence cumulative incidence impairments, impact...
Objective Individuals with deficiency of adenosine deaminase 2 ( DADA 2), a recently recognized autosomal recessive disease, present various systemic vascular and inflammatory manifestations, often young age at disease onset or early recurrent strokes. Their clinical features histologic findings overlap those childhood‐onset polyarteritis nodosa PAN ), primary “idiopathic” vasculitis. Despite similar presentation, individuals may respond better to biologic therapy than traditional...