A5091082145- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Cancer-related molecular mechanisms research
- Advanced Nanomaterials in Catalysis
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Photoacoustic and Ultrasonic Imaging
- Synthesis and biological activity
- PI3K/AKT/mTOR signaling in cancer
- Cancer Immunotherapy and Biomarkers
- Photodynamic Therapy Research Studies
- Advanced Drug Delivery Systems
- RNA Interference and Gene Delivery
- Electrospun Nanofibers in Biomedical Applications
- Bone Tissue Engineering Materials
- Cancer Mechanisms and Therapy
- Advanced biosensing and bioanalysis techniques
- Eicosanoids and Hypertension Pharmacology
- RNA modifications and cancer
- Angiogenesis and VEGF in Cancer
- Metal-Organic Frameworks: Synthesis and Applications
- Synthesis and Biological Evaluation
- Tissue Engineering and Regenerative Medicine
- Cancer, Hypoxia, and Metabolism
- Cancer, Stress, Anesthesia, and Immune Response
Southern Medical University
2018-2025
Sichuan University
2015-2025
Nanjing Medical University
2020-2025
Jiangsu Province Hospital
2020-2025
Stanford University
2018-2024
First Affiliated Hospital of Zhengzhou University
2024
Jiangxi Maternal and Child Health Hospital
2024
Fourth Affiliated Hospital of China Medical University
2013-2024
China Medical University
2013-2024
Xiamen University
2024
Abstract In addition to increasing the expression of programmed death-ligand 1 (PD-L1), tumor cells can also secrete exosomal PD-L1 suppress T cell activity. Emerging evidence has revealed that resists immune checkpoint blockade, and may contribute resistance therapy. this scenario, suppressing secretion tumor-derived exosomes aid Here, we develop an assembly exosome inhibitor (GW4869) ferroptosis inducer (Fe 3+ ) via amphiphilic hyaluronic acid. Cooperation between two active components in...
Development of second near-infrared (NIR-II) nanoparticles (NPs) with high biocompatibility, low toxicity, and singlet oxygen quantum yield (ΦΔ) to prevent tumor recurrence is highly desirable in molecular imaging photodynamic/immune combination therapy. Here, theranostic photosensitizer BODIPY (BDP)-I-N-anti-PD-L1 NPs were developed by encapsulating the BDP-I-N amphipathic poly(styrene-co-chloromethylstyrene)-graft-poly(ethylene glycol) nanocarriers through self-assembly functionalization...
We describe a novel antibiotic delivery system based on magnetic nanoparticles (NPs) conjugated to cell-penetrating peptide (CPP). Silica-coated iron oxide NPs were produced via co-deposition method, and coated by polyvinyl alcohol (PVA) polymeric network physicochemical binding. Vancomycin (VAN) was then entrapped into this PVA network. A hexapeptide sequence Gly-Ala-Phe-Pro-His-Arg, synthesized in the solid phase onto surface of NPs. The drug ratio incorporation carrier release monitored...
Abstract Fluorescence imaging in the second near‐infrared (NIR‐II) window holds impressive advantages of enhanced penetration depth and improved signal‐to‐noise ratio. Bright NIR‐II fluorophores with renal excretion ability low tissue accumulation are favorable for vivo molecular applications as they can render target‐mediated process easily distinguishable. Here, a probe (anti‐PD‐L1‐BGP6) comprising fluorophore (IR‐BGP6) covalently bonded to programmed cell death ligand‐1 monoclonal...
The development of hepatocellular carcinomas (HCC) depends on their local microenvironment and the induction neovascularization is a decisive step in tumor progression, since growth solid tumors limited by nutrient oxygen supply. Hypoxia critical factor that induces transcription hypoxia inducible factor-1α (HIF-1α) encoding gene HIF1A HIF-1α protein accumulation to promote angiogenesis. However, basis for transcriptional regulation expression HCC still unclear. Here, we show Bclaf1 levels...
Fluorescence imaging is a vital way to delineate the tumor boundaries. Here, we achieve NIR-II aggregation-induced emission luminogen (AIEgen) with fluorescence quantum yield (QY) of 12.6% in water through straightforward alkyl side chain modification. After loading AIEgen into polystyrene (PS) nanospheres, thermal deactivation pathway extremely limited, thereby concentrating absorption excitation on emission. The intensity further enhanced by 5.4 times, QY increases 21.1%, and signal...
Combination of photothermal therapy (PTT) and photodynamic (PDT) has become a promising cancer treatment in recent years. However, their applications are limited by complex synthetic protocols low efficacy. Hence, optimizing experimental approach improving the efficiency phototherapy is current research focus. In this work, various pyrolysis temperatures sizes zeolitic imidazolate framework-8 (ZIF-8) derived carbon nanoparticles (ZCNs) obtained simple direct ZIF-8 nanoparticles. Meanwhile,...
Nowadays, fluorescence detection has emerged as one of the most frequently used noninvasive biosensing methods to selectively monitor biological processes within living systems. Among fluorescent nanoparticles (NPs), gold nanoclusters (AuNCs) have been intensively studied because their intrinsic and endowed biocompatible surface. Herein, we selected an abundant, low-cost, sustainable plant protein, pea protein isolate (PPI), for its excellent biocompatibility, biodegradability, nonallergenic...
The objective of this study is to demonstrate the feasibility using solubility parameter as guidance for design and identification a stable micellar system with high drug loading capacity oral delivery. Using hydroxycamptothecin (HCPT) model drug, effect three hydrophobic blocks (fatty glycerides) grafted onto chitosan on stability HCPT-loaded nanoparticles formed by pH precipitation method were studied systematically. Flory–Huggins interaction (χFH) calculated group contribution (GCM)...
From the conception of atom economy to develop multifunctional nanomaterials, it is important construct nanomaterials by maximizing functional units while minimizing unnecessary components. Noteworthy, metal–organic framework (MOF) nanoparticles are excellent examples meet this idea. Current approaches for MOFs mainly based on encapsulation molecules or multistep modification; however, high risk leakage and burst release time-consuming complicated organic synthesis limit their applications....