A5101602367- Nanoplatforms for cancer theranostics
- interferon and immune responses
- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Nanoparticle-Based Drug Delivery
- Advanced Nanomaterials in Catalysis
- Ubiquitin and proteasome pathways
- Cancer Research and Treatments
- Luminescence Properties of Advanced Materials
- Extracellular vesicles in disease
- Inflammasome and immune disorders
- Peptidase Inhibition and Analysis
- Luminescence and Fluorescent Materials
- RNA Interference and Gene Delivery
- Ferroptosis and cancer prognosis
- Orbital Angular Momentum in Optics
- RNA modifications and cancer
- Lung Cancer Research Studies
- Hepatitis B Virus Studies
- Photodynamic Therapy Research Studies
- Cancer, Stress, Anesthesia, and Immune Response
- Gyrotron and Vacuum Electronics Research
- CAR-T cell therapy research
- Immune Response and Inflammation
Shandong First Medical University
2024-2025
Shandong Provincial Hospital
2024-2025
Academy of Medical Sciences
2025
University of Macau
2020-2024
University of Illinois Chicago
2001-2004
Tumor-derived exosome can suppress dendritic cells (DCs) and T functions. Excessive secretion of exosomal programmed death-ligand 1 (PD-L1) results in therapeutic resistance to PD-1/PD-L1 immunotherapy clinical failure. Restored by antiexosomal PD-L1 tactic intensify ferroptosis tumor vice versa. Diminishing suppression establishing a nexus may rescue the discouraging antitumor immunity. Here, we engineered phototheranostic metal-phenolic networks (PFG MPNs) an assembly semiconductor...
Radiotherapy, a mainstay of first-line cancer treatment, suffers from its high-dose radiation-induced systemic toxicity and radioresistance caused by the immunosuppressive tumor microenvironment. The synergy between radiosensitization immunomodulation may overcome these obstacles for advanced radiotherapy. Here, authors propose cooperated with stimulator interferon genes (STING) pathway activation strategy fabricating novel lanthanide-doped radiosensitizer-based metal-phenolic network,...
Abstract In addition to increasing the expression of programmed death-ligand 1 (PD-L1), tumor cells can also secrete exosomal PD-L1 suppress T cell activity. Emerging evidence has revealed that resists immune checkpoint blockade, and may contribute resistance therapy. this scenario, suppressing secretion tumor-derived exosomes aid Here, we develop an assembly exosome inhibitor (GW4869) ferroptosis inducer (Fe 3+ ) via amphiphilic hyaluronic acid. Cooperation between two active components in...
Abstract Radiotherapy (RT) is hampered by the limited oxygen in tumors, which could be potentiated via reprogramming metabolism and increasing utilization efficiency. Herein, a metal‐phenolic nanosensitizer (Hf‐PSP‐DTC@PLX) was integrated an acid‐sensitive hydrogen sulfide (H 2 S) donor (polyethylene glycol‐co‐polydithiocarbamates, PEG‐DTC) hafnium‐chelated polyphenolic semiconducting polymer (Hf‐PSP) amphiphilic (poloxamer F127, PLX). Hf‐PSP‐DTC@PLX elicited high imaging performance for...
Abstract Radiotherapy, although clinically effective in immunoactivation, still cannot radio‐functionalize tumor as a potent immunogenetic center. Given that newly found pyroptosis efficiently releases immunogenic damage‐associated molecular patterns, initiating radiotherapeutic may turn vision of radiotherapy‐induced immunity into reality. However, precondition is the absent gasdermin E (GSDME), which essentiates caspase‐3‐mediated pyroptosis, can be well translated cancer cells. Here, an...
Abstract Recently, lanthanide nanoparticles have aroused widespread interest in cancer theranostics by virtue of their excellent photoresponsive performance deep‐seated tumors. The abundant ladder‐like energy levels, controllable emission profiles, and unique photoluminescence properties make highly efficient for deep skin‐penetration near‐infrared (NIR) light, concentrating light tumors with negligible scattering minimal autofluorescence from biological tissues. High‐ Z radio‐sensitization...
Abstract Cancer cells can upregulate the MYC expression to repair radiotherapy‐triggered DNA damage, aggravating therapeutic resistance and tumor immunosuppression. Epigenetic treatment targeting MYC‐transcriptional abnormality may intensively solve this clinical problem. Herein, 5‐Aza (a methyltransferase inhibitor) ITF‐2357 histone deacetylase are engineered into a tungsten‐based nano‐radiosensitizer (PWAI), suppress rising awaken robust radiotherapeutic antitumor immunity. Individual...
We have developed an instrument for micromanipulation of single DNA molecules end labeled with $3\text{\ensuremath{-}}\ensuremath{\mu}\mathrm{m}$-diameter paramagnetic particles. A small, permanent magnet that can be moved as close $10\phantom{\rule{0.3em}{0ex}}\ensuremath{\mu}\mathrm{m}$ to the particle being manipulated generate forces in excess $200\phantom{\rule{0.3em}{0ex}}\mathrm{pN}$, significantly larger than obtained other recent ``magnetic-tweezer'' studies. Our generates these...
Intratumoral CD8
Abstract New generation of nanomaterials with organelle‐level precision provide significant promise for targeted attacks on mitochondria, exhibiting remarkable therapeutic potency. Here, we report a novel amphiphilic phenolic polymer (PF) the mitochondria‐targeted photodynamic therapy (PDT), which can trigger excessive mitochondrial DNA (mtDNA) damage by synergistic action oxidative stress and furan‐mediated cross‐linking. Moreover, units PF enable further self‐assembly Mn 2+ via...
The reprogramming of tumor metabolism presents a substantial challenge for effective immunotherapy, playing crucial role in developing an immunosuppressive microenvironment. In particular, the degradation amino acid L-tryptophan (Trp) to kynurenine (Kyn) by indoleamine-pyrrole 2,3-dioxygenase 1 (IDO1) is one most clinically validated pathways immune suppression. Thus, regulating Trp/Kyn IDO1 inhibition represents promising strategy enhancing immunotherapy. Herein, metabolism-regulated...
Malignant melanoma cell-intrinsic PD-1:PD-L1 interaction thrusts tumorigenesis, angiogenesis, and radioresistance via mTOR hyperactivation to aggravate circumjacent aggression. Interdicting intrinsic growth signals, including the blockade of PD-L1 signaling concurrently, cooperative with radiotherapy may provide a vigorous repertoire alleviate tumor encumbrance. Thence, we design three-pronged platinum@polymer-catechol nanobraker deliver inhibitor TAK228 anti-PD-L1 antibody (aPD-L1) for...
Malignant melanoma is an aggressive skin cancer with a high metastatic and mortality rate. Owing to genetic alterations, cells are resistant apoptosis induction, which reduces the efficacy of most adjuvant systemic anticancer treatments in clinical. Here, noninvasive strategy for anti-melanoma immunotherapy based on manganese-coordinated nanomedicine provided. Supplemented photoirradiation, photon-mediated reactive oxygen species generation by photosensitizer chlorin e6 initiates...
Proteolysis targeting chimera (PROTAC) has recently emerged as a promising strategy to selectively degrade target proteins in the treatment of various diseases. However, it low bioavailability due strong hydrophobicity, poor membrane permeability, and nonspecific distribution vivo, which greatly limits its application. In this study, self-delivery PROTAC nanoparticles (designated CP NPs) integrating gefitinib-based PROTACs photosensitizers were developed efficiently mutated epidermal growth...
Photothermal therapy (PTT) achieves substantive therapeutic progress in certain tumor types without exogenous agents but is hampered by the over-activated inflammatory response or recurrence some cases. Herein, we technically developed metal-polyphenolic nanosystem with precise NIR-II fluorescence-imaging guidance for combining hafnium (Hf)-sensitized radiotherapy PTT to regress growth.
Abstract Ferroptosis initiation is often utilized for synergistic immunotherapy. While, current immunotherapy limited by an immunosuppressive tumor microenvironment (TME), and ferroptosis insufficient reactive oxygen species (ROS) ferroptotic lipids in cells. Here, arachidonic acid (AA) loaded nanosystem (CTFAP) developed to mutually reinforce cancer augmenting ROS generation modulating lipids. CTFAP composed of acid‐responsive core calcium peroxide (CaO 2 ) nanoparticles, sponsor AA,...
Effective therapeutic approaches against head and neck squamous cell carcinoma (HNSCC), which is a prevalent malignant tumor, are currently lacking. Although immunotherapy has emerged as promising strategy for treating HNSCC, its efficacy severely limited by the immunosuppressive tumor microenvironment. Self-delivery nanoparticles, comprising Toll-like receptor (TLR) agonists photosensitizers, were successfully developed to address this challenge in combinatorial HNSCC treatment. After...
The enzymes that pass DNA through so as to remove entanglements, adenosine-triphosphate-hydrolyzing type-II topoisomerases, are able suppress the probability of self-entanglements (knots) and mutual entanglements (links) between $\ensuremath{\sim}10 \mathrm{kb}$ plasmids, well below levels expected, given assumption topoisomerases segments at random by thermal motion. This implies a 10-nm topoisomerase can somehow sense topology large DNA. We previously introduced ``kinetic proofreading''...
Abstract New generation of nanomaterials with organelle‐level precision provide significant promise for targeted attacks on mitochondria, exhibiting remarkable therapeutic potency. Here, we report a novel amphiphilic phenolic polymer (PF) the mitochondria‐targeted photodynamic therapy (PDT), which can trigger excessive mitochondrial DNA (mtDNA) damage by synergistic action oxidative stress and furan‐mediated cross‐linking. Moreover, units PF enable further self‐assembly Mn 2+ via...