A5020681563- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Advanced Wireless Communication Techniques
- Radio Wave Propagation Studies
- Lung Cancer Research Studies
- Wireless Communication Networks Research
- Peptidase Inhibition and Analysis
- Laser and Thermal Forming Techniques
- Immune cells in cancer
- Cancer, Stress, Anesthesia, and Immune Response
- Advanced MIMO Systems Optimization
- PAPR reduction in OFDM
- Anodic Oxide Films and Nanostructures
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Spacecraft Design and Technology
- Protein Degradation and Inhibitors
- interferon and immune responses
- Millimeter-Wave Propagation and Modeling
- Advanced biosensing and bioanalysis techniques
- Advanced Numerical Methods in Computational Mathematics
- RNA Interference and Gene Delivery
- Satellite Communication Systems
- Metal Forming Simulation Techniques
Shandong First Medical University
2024-2025
Shandong Provincial Hospital
2024-2025
Academy of Medical Sciences
2025
Beijing University of Posts and Telecommunications
2023-2024
The reprogramming of tumor metabolism presents a substantial challenge for effective immunotherapy, playing crucial role in developing an immunosuppressive microenvironment. In particular, the degradation amino acid L-tryptophan (Trp) to kynurenine (Kyn) by indoleamine-pyrrole 2,3-dioxygenase 1 (IDO1) is one most clinically validated pathways immune suppression. Thus, regulating Trp/Kyn IDO1 inhibition represents promising strategy enhancing immunotherapy. Herein, metabolism-regulated...
Exosomes (Exos) are emerging as noninvasive biomarkers for diagnosis and progression monitoring of gastric cancer (GC). However, the heterogeneity discrimination ultrasensitive quantification Exos presents a considerable analytical challenge, thereby impeding severely their clinical application. Herein, we propose an integrated terahertz metasensing platform in distinct subtypes GC single step-through simultaneous evaluation category richness level membrane proteins. Characterized by...
Proteolysis targeting chimera (PROTAC) has recently emerged as a promising strategy to selectively degrade target proteins in the treatment of various diseases. However, it low bioavailability due strong hydrophobicity, poor membrane permeability, and nonspecific distribution vivo, which greatly limits its application. In this study, self-delivery PROTAC nanoparticles (designated CP NPs) integrating gefitinib-based PROTACs photosensitizers were developed efficiently mutated epidermal growth...
Effective therapeutic approaches against head and neck squamous cell carcinoma (HNSCC), which is a prevalent malignant tumor, are currently lacking. Although immunotherapy has emerged as promising strategy for treating HNSCC, its efficacy severely limited by the immunosuppressive tumor microenvironment. Self-delivery nanoparticles, comprising Toll-like receptor (TLR) agonists photosensitizers, were successfully developed to address this challenge in combinatorial HNSCC treatment. After...
As an important technology for achieving 6G global access, low Earth orbit satellite (LEO-Sat) communication still encounters the challenges of scarce spectrum resources and serious Doppler effect. To improve performance image transmission in LEO-Sat system, this paper proposes approach that combines semantic with orthogonal time-frequency space (OTFS) modulation to effectively mitigate severe effect enhance efficiency. The NTN-TDL-D model 3GPP is employed simulate channels introduce noise...
Low Earth orbit (LEO) satellite communication (SATCOM) is a pivotal component of sixth-generation (6G) wireless communication. The dependability satellite-to-ground severely hampered by large-scale Doppler frequency offsets. We propose carrier offset (CFO) estimator applied to orthogonal time space (OTFS) modulation. By inserting the pilot and maximum length sequences (MLS) for each OTFS frame in delay-Doppler domain, can search corresponding equal-amplitude MLS along different dimensions...