A5100393415- Nanoplatforms for cancer theranostics
- Immunotherapy and Immune Responses
- Nanoparticle-Based Drug Delivery
- Tropical and Extratropical Cyclones Research
- Advanced Nanomaterials in Catalysis
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Extracellular vesicles in disease
- Ocean Waves and Remote Sensing
- interferon and immune responses
- Cancer, Stress, Anesthesia, and Immune Response
- Ultrasound and Hyperthermia Applications
- Luminescence and Fluorescent Materials
- Cancer, Hypoxia, and Metabolism
- Photoacoustic and Ultrasonic Imaging
- Graphene and Nanomaterials Applications
- Inflammasome and immune disorders
- Photodynamic Therapy Research Studies
- Hydrogels: synthesis, properties, applications
- Bone and Dental Protein Studies
- Plant and Fungal Species Descriptions
- Ferroptosis and cancer prognosis
- Plant Diversity and Evolution
- Advanced battery technologies research
- Disaster Management and Resilience
China Medical University
2024-2025
China Tobacco
2024
NOAA National Centers for Environmental Prediction
2024
NOAA National Weather Service
2024
NOAA Environmental Modeling Center
2024
Jiaxing Vocational Technical College
2024
Yangzhou University
2022-2024
University of Macau
2019-2023
National Oceanic and Atmospheric Administration
2021
Tongde Hospital of Zhejiang Province
2016
Tumor-derived exosome can suppress dendritic cells (DCs) and T functions. Excessive secretion of exosomal programmed death-ligand 1 (PD-L1) results in therapeutic resistance to PD-1/PD-L1 immunotherapy clinical failure. Restored by antiexosomal PD-L1 tactic intensify ferroptosis tumor vice versa. Diminishing suppression establishing a nexus may rescue the discouraging antitumor immunity. Here, we engineered phototheranostic metal-phenolic networks (PFG MPNs) an assembly semiconductor...
Radiotherapy, a mainstay of first-line cancer treatment, suffers from its high-dose radiation-induced systemic toxicity and radioresistance caused by the immunosuppressive tumor microenvironment. The synergy between radiosensitization immunomodulation may overcome these obstacles for advanced radiotherapy. Here, authors propose cooperated with stimulator interferon genes (STING) pathway activation strategy fabricating novel lanthanide-doped radiosensitizer-based metal-phenolic network,...
Abstract In addition to increasing the expression of programmed death-ligand 1 (PD-L1), tumor cells can also secrete exosomal PD-L1 suppress T cell activity. Emerging evidence has revealed that resists immune checkpoint blockade, and may contribute resistance therapy. this scenario, suppressing secretion tumor-derived exosomes aid Here, we develop an assembly exosome inhibitor (GW4869) ferroptosis inducer (Fe 3+ ) via amphiphilic hyaluronic acid. Cooperation between two active components in...
Abstract Photothermal therapy (PTT), one of the most‐potent cancer therapeutic strategies known, is highlighted with excessive inflammatory response, while ablating immunogenic death. This hyperactive immune response may override PTT‐triggered immunogenicity, exacerbate skin empyrosis, and incur permanent tissue injury high‐profile tumor regeneration. Therefore, an anticancer balance between pathological protective urgently needed for advanced photothermal tactic. Herein, a gas‐modulated...
Nanomedicine has revolutionized cancer therapeutic strategies but not completely changed the outcomes of tricky tumors that evolve a sophisticated immunosuppressive tumor microenvironment (TME) such as acidification. Here, metal-phenolic network-based nanocomplex embedded with lactate oxidase (LOX) and mitochondrial respiration inhibitor atovaquone (ATO) was constructed for TME remodeling sonodynamic therapy (SDT). In this nanocomplex, sonosensitizer chlorin e6-conjugated polyphenol...
Abstract Radiotherapy (RT) is hampered by the limited oxygen in tumors, which could be potentiated via reprogramming metabolism and increasing utilization efficiency. Herein, a metal‐phenolic nanosensitizer (Hf‐PSP‐DTC@PLX) was integrated an acid‐sensitive hydrogen sulfide (H 2 S) donor (polyethylene glycol‐co‐polydithiocarbamates, PEG‐DTC) hafnium‐chelated polyphenolic semiconducting polymer (Hf‐PSP) amphiphilic (poloxamer F127, PLX). Hf‐PSP‐DTC@PLX elicited high imaging performance for...
Abstract Radiotherapy, although clinically effective in immunoactivation, still cannot radio‐functionalize tumor as a potent immunogenetic center. Given that newly found pyroptosis efficiently releases immunogenic damage‐associated molecular patterns, initiating radiotherapeutic may turn vision of radiotherapy‐induced immunity into reality. However, precondition is the absent gasdermin E (GSDME), which essentiates caspase‐3‐mediated pyroptosis, can be well translated cancer cells. Here, an...
Abstract Radiotherapy (RT) based on DNA damage and reactive oxygen species (ROS) generation has been clinically validated in various types of cancer. However, high dose‐dependent induced toxicity to tissues, non‐selectivity, radioresistance greatly limit the application RT. Herein, an oxygen‐enriched X‐ray nanoprocessor Hb@Hf‐Ce6 nanoparticle is developed for improving therapeutic effect RT‐radiodynamic therapy (RDT), enhancing modulation hypoxia tumor microenvironment (TME) promoting...
Engineering multifunctional nanoplatforms with high therapeutic benefits has become a promising strategy for intractable cancer treatment. A novel polyphenol-based nanocomplex was designed to evoke highly efficacious immunosurveillance while localizing therapy on the primary tumor and minimize systemic side effects. This is prepared via metal-polyphenol coordination by encapsulating natural polyphenol, gossypol, newly synthesized polyphenol derivative, polyethylene glycol-Chlorin e6 (Ce6)....
Cancer lactate metabolic reprogramming induces an elevated level of extracellular and H+, leading to acidic immunosuppressive tumor microenvironment (TEM). High lactic acid may affect the programs various cells that comprise antitumor immune response, therefore, restricting immune-mediated destruction, therapeutic resistance unsatisfactory prognosis. Here, we report a metal-phenolic coordination-based nanocomplex loaded with natural polyphenol galloflavin, which inhibits function...
Recently, emotion recognition has become a hot topic in human-computer interaction. If computers could understand human emotions, they interact better with their users. This paper proposes novel method to recognize emotions (neutral, happy, and angry) using smart bracelet built-in accelerometer.In this study, total of 123 participants were instructed wear customized accelerometer that can track record movements. Firstly, walked two minutes as normal, which served walking behaviors neutral...
Abstract Stress response to radiation sensitizes immunologically nonresponsive tumors cytotoxic T‐lymphocyte‐associated protein 4 (CTLA‐4) therapy. The combination of radiotherapy (RT) and CTLA‐4 immune checkpoint blockade therapy has been clinically adopted yielded outstanding cooperative effects from restricted local lethality systemic response. However, this induces resistance caused by T cell depletion increased programmed death‐ligand 1 (PD‐L1) expression in tumor cells. Hence,...
Abstract Oxygen reduction reaction (ORR) electrocatalysts are essential for widespread application of quasi‐solid‐state Zn‐air batteries (ZABs), but the well‐known Fe‐N‐C single‐atom catalysts (SACs) suffer from low activity and stability because unfavorable strong adsorption oxygenated intermediates. Herein, study synthesizes dual Fe/I single atoms anchored on N‐doped carbon nanorods (Fe/I‐N‐CR) via a metal–organic framework (MOF)‐mediated two‐step tandem‐pyrolysis method. Atomic‐level I...
Abstract The Hurricane Weather Research and Forecasting Model (HWRF) was the flagship hurricane model at NOAA’s National Centers for Environmental Prediction 16 years a state-of-the-art tool tropical cyclone (TC) intensity prediction Service across globe. HWRF joint development between NOAA research operations, specifically Modeling Center Atlantic Oceanographic Meteorological Laboratory. Significant support also came from Center, Developmental Testbed University Corporation Atmospheric...
For the aroma enhancement research of heated cigarettes, it is worth exploring whether tobacco can be pyrolyzed into pyrolysis liquids containing a large number volatile components. In this study, were prepared in subcritical/supercritical ethanol, and their applications cigarettes investigated. The optimal conditions supercritical liquefaction reactions determined by optimizing reaction time, liquid/solid mass ratio temperature conditions. Moreover, effect on components was investigated...
Malignant melanoma cell-intrinsic PD-1:PD-L1 interaction thrusts tumorigenesis, angiogenesis, and radioresistance via mTOR hyperactivation to aggravate circumjacent aggression. Interdicting intrinsic growth signals, including the blockade of PD-L1 signaling concurrently, cooperative with radiotherapy may provide a vigorous repertoire alleviate tumor encumbrance. Thence, we design three-pronged platinum@polymer-catechol nanobraker deliver inhibitor TAK228 anti-PD-L1 antibody (aPD-L1) for...
Abstract The tumor hypoxic microenvironment is a dynamic status that closely related to growth, metastasis, clearance, and recurrence. Hypoxic conditions are present in almost all tumors, which greatly reduce the clinical effects of therapy. Considering physical tolerance dose‐related side cancer radiotherapy (RT) patients, herein, universal two‐step strategy designed based on safe, noninvasive, deep penetration, intensity‐controlled ultrasound method alleviate hypoxia enhance RT. first step...