A5073285894- Heat shock proteins research
- Endoplasmic Reticulum Stress and Disease
- Protein Structure and Dynamics
- Migration and Labor Dynamics
- Cancer, Lipids, and Metabolism
- Genetics, Aging, and Longevity in Model Organisms
- Migration, Aging, and Tourism Studies
- Cancer, Hypoxia, and Metabolism
- Radiation Therapy and Dosimetry
- Aortic aneurysm repair treatments
- Spinal Fractures and Fixation Techniques
- Pericarditis and Cardiac Tamponade
- Plant Gene Expression Analysis
- BRCA gene mutations in cancer
- Suicide and Self-Harm Studies
- Peroxisome Proliferator-Activated Receptors
- Gun Ownership and Violence Research
- Intergenerational Family Dynamics and Caregiving
- Glutathione Transferases and Polymorphisms
- Ultrasound and Hyperthermia Applications
- Sirtuins and Resveratrol in Medicine
- Cancer Risks and Factors
- Aortic Disease and Treatment Approaches
- Injury Epidemiology and Prevention
- Cancer-related molecular mechanisms research
Southern Medical University
2015-2024
Inner Mongolia University
2023
Shantou University
2007
Second Affiliated Hospital of Shantou University Medical College
2007
The development of hepatocellular carcinomas (HCC) depends on their local microenvironment and the induction neovascularization is a decisive step in tumor progression, since growth solid tumors limited by nutrient oxygen supply. Hypoxia critical factor that induces transcription hypoxia inducible factor-1α (HIF-1α) encoding gene HIF1A HIF-1α protein accumulation to promote angiogenesis. However, basis for transcriptional regulation expression HCC still unclear. Here, we show Bclaf1 levels...
Abdominal aortic aneurysm (AAA) is a catastrophic disease with little effective therapy, likely due to the limited understanding of mechanisms underlying AAA development and progression. ATF3 (activating transcription factor 3) has been increasingly recognized as key regulator cardiovascular diseases. However, role in progression remains elusive.
B‐cell lymphoma 2 (Bcl‐2)‐associated transcription factor 1 (Bclaf1) is known to be involved in diverse biological processes, but, date, there has been no evidence for any functional role of Bclaf1 hepatocellular carcinoma (HCC) progression. Here, we demonstrate that frequently up‐regulated HCC and up‐regulation associated with Edmondson grade, lower overall survival rates, poor prognosis. Overexpression cell lines HepG2 Huh7 promoted proliferation considerably, whereas knockdown had the...
Hypoxia stress plays a pivotal role in tumor formation, proliferation, and invasion. Conventional chemotherapy is less effective the hypoxia microenvironment of solid tumor. Heat shock protein 90 (Hsp90) an important molecular chaperone cancer cells has been pharmaceutical target for decades. However, Hsp90 inhibitors demonstrate limited effect on mechanism underlying not clear. To determine whether impairs therapeutic N-terminal inhibitor, 17-demethoxygeldanamycin hydrochloride (17-DMAG),...
Abstract As a conserved molecular chaperone, heat shock protein 90 (Hsp90) maintains the stability and homeostasis of oncoproteins helps cancer cells survive. DNA-dependent kinase catalytic subunit (DNA-PKcs) plays pivotal role in non-homologous end joining pathway for DNA double-strand breaks (DSB) repair. Tumor contain higher levels DNA-PKcs to survive by hostile tumor microenvironment various antitumor therapies. Here, we showed that increased Hsp90α, Hsp90β, correlated with poor overall...
Rotenone, a component of pesticides, is widely used in agriculture and potentially causes Parkinson's disease (PD). However, the regulatory mechanisms rotenone-induced PD are unclear. Here, we revealed novel feedback mechanism p38-Parkin-ROS regulating PD. Rotenone treatment led to not only activation p38 but also Parkin inactivation reactive oxygen species (ROS) overproduction SN4741 cells. Meanwhile, regulated phosphorylation at serine 131 disrupt Parkin-mediated mitophagy. Notably, both...
Background Gaps remained in the updated information of firearm violence (FV) burden from a global landscape. Understanding FV could contribute to decision-making. Methods Data on burden, including physical by (PVF), self-harm (SHF), and unintentional injuries (UFI), were extracted Global Burden Disease 2019. The temporal trends age-standardized rate (ASR) estimated using annual percentage change (EAPC). Results In 2019, PVF, SHF, UFI reported 710.64 × 10 3 , 335.25 2,133.88 respectively,...
Esophageal cancer (EC) is the sixth cause of cancer-related deaths and still a significant public health problem globally. Nitrosamines exposure represents major concern increasing EC risks. Exploring mechanisms induced by nitrosamines may contribute to prevention early detection EC. However, mechanism nitrosamine carcinogenesis remains unclear. Ribonucleic acid export 1 (RAE1), has an important role in mediating diverse types, but, date, there been no study for any functional RAE1...
Abstract Due to the lack of effective treatment, hepatocellular carcinoma (HCC) is one malignancies with low survival rates worldwide. Combination hyperthermia and chemotherapy has shown promising results in several abdominal tumours, but high expression HSP90 tumours attenuated efficacy hyperthermia. Thus a combination inhibition might be feasible therapeutic strategy for HCC. One hepatic cell line (L02) two HCC lines (Huh7 HepG2) were heated at 42 °C 0, 0.5 or 4 h without 100 nM...
With the intensification of population aging in rural areas, it becomes increasingly important to analyze post-retirement migration intention residents and variables influencing these intentions. However, there is a lack research on this point. In study, we focused aged 45 60 used logistic regression model investigate demographic personal their intention. The data study were collected from one hundred sixty-four households three areas Inner Mongolia 2011. From results found that gender,...
Abstract Background Studies on the relationship between personal history of irradiation and breast cancer have been reported for a long time. Still, epidemiological studies not conclusive, causal is unclear. To address this issue, we employed Mendelian randomisation (MR) analysis to examine association individual radiation exposure cancer. Methods We used series quality control methods select single nucleotide polymorphism (SNP) closely related exposure. Meanwhile, several were analyse...
With the intensification of population aging in rural areas, it becomes increasingly important to analyze post-retirement migration intention residents and variables influencing these intentions. In this study, we focus on aged 45 60 investigate main that influence residents, using survey data collected from 164 households three different areas logistic regression model. From result found gender, part-time employment, savings level, children's residence occupation stability,...
Abstract Background As a kind of cardiovascular disease, the association between acute pericarditis and ALT has not been reported, whether there is causal relationship still unclear. Therefore, we aimed to explore potential risk using Mendelian randomization (MR) design. Methods We used large consortia candidate gene summary data from genome-wide study (GWAS) levels liver enzymes (alanine transaminase) pericarditis. The IEU OPEN GWAS Project were for enzyme included 437,267 participants....
<p>Supplementary Data</p>
<p>Supplemental Figures 1-7 Merged PDF</p>
<div>Abstract<p>As a conserved molecular chaperone, heat shock protein 90 (Hsp90) maintains the stability and homeostasis of oncoproteins helps cancer cells survive. DNA-dependent kinase catalytic subunit (DNA-PKcs) plays pivotal role in non-homologous end joining pathway for DNA double-strand breaks (DSB) repair. Tumor contain higher levels DNA-PKcs to survive by hostile tumor microenvironment various antitumor therapies. Here, we showed that increased Hsp90α, Hsp90β, correlated...
<div>Abstract<p>As a conserved molecular chaperone, heat shock protein 90 (Hsp90) maintains the stability and homeostasis of oncoproteins helps cancer cells survive. DNA-dependent kinase catalytic subunit (DNA-PKcs) plays pivotal role in non-homologous end joining pathway for DNA double-strand breaks (DSB) repair. Tumor contain higher levels DNA-PKcs to survive by hostile tumor microenvironment various antitumor therapies. Here, we showed that increased Hsp90α, Hsp90β, correlated...
<p>Supplementary Data</p>
<p>Supplemental Figures 1-7 Merged PDF</p>