A5101679955- Heat shock proteins research
- Endoplasmic Reticulum Stress and Disease
- Protein Structure and Dynamics
- Genetics, Aging, and Longevity in Model Organisms
- Mitochondrial Function and Pathology
- Sirtuins and Resveratrol in Medicine
- ATP Synthase and ATPases Research
- Enzyme Structure and Function
- Connexins and lens biology
- Cancer, Lipids, and Metabolism
- Extracellular vesicles in disease
Southern Medical University
2021-2024
Cancer cells compensate with increasing mitochondria-derived vesicles (MDVs) to maintain mitochondrial homeostasis, when canonical MAP1LC3B/LC3B (microtubule associated protein 1 light chain 3 beta)-mediated mitophagy is lacking. MDVs promote the transport of components into extracellular (EVs) and induce tumor metastasis. Although HSP90 (heat shock 90) chaperones hundreds client proteins its inhibitors suppress tumors, inhibitors-related chemotherapy unexpected Herein, we find that...
Abstract As a conserved molecular chaperone, heat shock protein 90 (Hsp90) maintains the stability and homeostasis of oncoproteins helps cancer cells survive. DNA-dependent kinase catalytic subunit (DNA-PKcs) plays pivotal role in non-homologous end joining pathway for DNA double-strand breaks (DSB) repair. Tumor contain higher levels DNA-PKcs to survive by hostile tumor microenvironment various antitumor therapies. Here, we showed that increased Hsp90α, Hsp90β, correlated with poor overall...
Heat shock protein 90 (Hsp90) has been an important therapeutic target for cancer therapy decades. Unexpectedly, the monotherapy of N-terminal Hsp90 inhibitor STA9090 related clinical trials halted in phase III, and metastases were reported animal models with treatment inhibitors. Vacuolar sorting-associated 35 (VPS35) plays a vital role endosome-derived EV (extracellular vesicle) traffic neurodegeneration diseases, but no vps35 tumors till now. Since tumor derived EVs contributes to...
Voltage-dependent anion-selective channel protein 1 (VDAC1) is the most abundant in mitochondrial outer membrane and plays a crucial role control of hepatocellular carcinoma (HCC) progress. Our previous research found that cytosolic molecular chaperone heat shock 90 (Hsp90) interacted with VDAC1, but effect C-terminal N-terminal domains Hsp90 on formation VDAC1 oligomers unclear. In this study, we focused domain oligomerization, ubiquitination, activity. We inhibitor Novobiocin promoted...
<p>Supplementary Data</p>
<p>Supplemental Figures 1-7 Merged PDF</p>
<div>Abstract<p>As a conserved molecular chaperone, heat shock protein 90 (Hsp90) maintains the stability and homeostasis of oncoproteins helps cancer cells survive. DNA-dependent kinase catalytic subunit (DNA-PKcs) plays pivotal role in non-homologous end joining pathway for DNA double-strand breaks (DSB) repair. Tumor contain higher levels DNA-PKcs to survive by hostile tumor microenvironment various antitumor therapies. Here, we showed that increased Hsp90α, Hsp90β, correlated...
<div>Abstract<p>As a conserved molecular chaperone, heat shock protein 90 (Hsp90) maintains the stability and homeostasis of oncoproteins helps cancer cells survive. DNA-dependent kinase catalytic subunit (DNA-PKcs) plays pivotal role in non-homologous end joining pathway for DNA double-strand breaks (DSB) repair. Tumor contain higher levels DNA-PKcs to survive by hostile tumor microenvironment various antitumor therapies. Here, we showed that increased Hsp90α, Hsp90β, correlated...
<p>Supplementary Data</p>
<p>Supplemental Figures 1-7 Merged PDF</p>