A5100410369- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Sedative Agents
- Anesthesia and Neurotoxicity Research
- Cardiac electrophysiology and arrhythmias
- Cardiac Ischemia and Reperfusion
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Pain Management
- Cardiac Arrest and Resuscitation
- Hemodynamic Monitoring and Therapy
- Ion channel regulation and function
- Nausea and vomiting management
- Mitochondrial Function and Pathology
- Cardiovascular Function and Risk Factors
- Neurological Disease Mechanisms and Treatments
- Glaucoma and retinal disorders
- Spine and Intervertebral Disc Pathology
- Cardiac and Coronary Surgery Techniques
- Antiplatelet Therapy and Cardiovascular Diseases
- Endoplasmic Reticulum Stress and Disease
- Cardiac Valve Diseases and Treatments
- Respiratory Support and Mechanisms
- Cardiac Imaging and Diagnostics
- Venous Thromboembolism Diagnosis and Management
- Traditional Chinese Medicine Analysis
- Coronary Interventions and Diagnostics
University of California, Davis
2016-2025
Tianjin Medical University Cancer Institute and Hospital
2008-2025
Ministry of Education of the People's Republic of China
2022-2025
Capital Medical University
2008-2025
Shandong First Medical University
2016-2025
Beijing Children’s Hospital
2013-2025
Shanghai Mental Health Center
2025
Shanghai University
2025
Central South University
2013-2024
Qingdao Municipal Hospital
2009-2024
The COVID-19 outbreak has led to 80,409 diagnosed cases and 3,012 deaths in mainland China based on the data released March 4, 2020. Approximately 3.2% of patients with required intubation invasive ventilation at some point disease course. Providing best practices regarding for an overwhelming number amid enhanced risk cross-infection is a daunting undertaking. authors presented experience caring critically ill Wuhan. It extremely important follow strict self-protection precautions. Timely,...
A new class of inflammatory CD4+ T cells that produce interleukin-17 (IL-17) (termed Th17) has been identified, which plays a critical role in numerous conditions and autoimmune diseases. The active form vitamin D, 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], direct repressive effect on the expression IL-17A both human mouse cells. In vivo treatment mice with ongoing experimental encephalomyelitis (EAE; model multiple sclerosis) diminishes paralysis progression disease reduces IL-17A-secreting...
Cardiac surgery is associated with a high risk of cardiovascular and other complications that translate into increased mortality healthcare costs. This retrospective study was designed to determine whether the perioperative use dexmedetomidine could reduce incidence after cardiac surgery. A total 1134 patients who underwent coronary artery bypass plus valvular or procedures were included. Of them, 568 received intravenous infusion 566 did not. Data adjusted propensity scores, multivariate...
Pyroptosis, systemic inflammation, and mitochondrial apoptosis are the three primary contributors to sepsis's multiple organ failure, ultimate cause of high clinical mortality. Currently, drugs under development only target a single pathogenesis, which is obviously insufficient. In this study, an acid-responsive hollow mesoporous polydopamine (HMPDA) nanocarrier that highly capable carrying both hydrophilic drug NAD
Activation of stress response genes can impart cellular tolerance to environmental stress. Iodoacetamide (IDAM) is an alkylating toxicant that up-regulates expression hsp70 (Liu, H., Lightfoot, D. L., and Stevens, J. L. (1996) Biol. Chem. 271, 4805-4812) grp78 in LLC-PK1 renal epithelial cells. Therefore, we used IDAM determine the role these toxic chemicals. Prior heat shock did not protect cells from but pretreatment with trans-4,5-dihydroxy-1,2-dithiane (DTTox), thapsigargin, or...
There are two isoforms of sphingosine kinase (SphK) that catalyze the formation 1-phosphate, a potent sphingolipid mediator. Whereas SphK1 stimulates growth and survival, here we show SphK2 enhanced apoptosis in diverse cell types also suppressed cellular proliferation. Apoptosis was preceded by cytochrome c release activation caspase-3. SphK2-induced independent 1-phosphate receptors. Sequence analysis revealed contains 9-amino acid motif similar to present BH3-only proteins, pro-apoptotic...
Pyridine nucleotides regulate the cardiac Na(+) current (I(Na)) through generation of reactive oxygen species (ROS).We investigated source ROS induced by elevated NADH.In human embryonic kidney (HEK) cells stably expressing channel, decrease I(Na) (52±9%; P<0.01) cytosolic NADH application (100 μmol/L) was reversed mitoTEMPO, rotenone, malonate, DIDS (4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid), PK11195, and 4'-chlorodiazepam, a specific scavenger mitochondrial superoxide inhibitors...
Oxidants are important human toxicants. Increased intracellular free Ca<sup>2+</sup> may be critical for oxidant toxicity, but this mechanism remains controversial. Furthermore, oxidants damage the endoplasmic reticulum (ER) and release ER Ca<sup>2+</sup>, role of in toxicity regulation during is also unclear.<i>tert</i>-Butylhydroperoxide (TBHP), a prototypical organic oxidant, causes oxidative stress an increase Ca<sup>2+</sup>. Therefore, we addressed oxidant-induced cell death...
Transcriptional activation of heat shock protein genes is a common response to proteotoxic stress. Many drugs and chemicals that form reactive electrophiles modify structure by binding covalently nucleophilic functional groups. Although many these agents also activate transcription the inducible member hsp70 gene family, it not clear if covalent modification cellular proteins per se sufficient. Iodoacetamide (IDAM) prototypical alkylating toxicant induces transcription. However, IDAM-induced...
Rationale: Previously, we demonstrated that a deoxycorticosterone acetate (DOCA)-salt hypertensive mouse model produces cardiac oxidative stress and diastolic dysfunction with preserved systolic function. Oxidative has been shown to increase late inward sodium current (I Na ), reducing the net cytosolic Ca 2+ efflux. Objective: in DOCA-salt may I , resulting amenable treatment ranolazine. Methods Results: Echocardiography detected evidence of mice improved after ranolazine (E/E′:sham,...
Retrospective functional and radiographic analysis of symptomatic patients with de novo degenerative lumbar thoracolumbar scoliosis.To evaluate the parameters presenting adult scoliosis correlate them scores.Previous studies have been inconclusive as to correlation clinical symptomatology.Radiographic 58 consecutive was performed using posteroanterior lateral 36-inch standing radiographs. Measurements included curve type, location, magnitude, coronal alignment, sagittal anteroposterior...
A limit to the clinical benefit of radiotherapy is not an incapacity eliminate tumor cells but rather a on its capacity do so without destroying normal tissue and inducing inflammation. Recent evidence reveals that inflammasome essential for mediating radiation-induced cell damage. In this study, using primary cultured bone marrow-derived macrophages (BMDM) mouse radiation model, we explored role NLRP3 activation secondary pyroptosis underlying immune death. We observed increasing proportion...
Previously, we showed that a mouse model (ACE8/8) of cardiac renin-angiotensin system activation has high rate spontaneous ventricular tachycardia and sudden death secondary to reduction in connexin43 level. Angiotensin-II increases reactive oxygen species (ROS) production, ACE8/8 mice show increased ROS. We sought determine the source ROS whether played role arrhythmogenesis.Wild-type with without 2 weeks treatment L-NIO (NO synthase inhibitor), sepiapterin (precursor tetrahydrobiopterin),...
Abstract Exosomes play critical roles in regulating various physiological and pathological processes, including immune stimulation, suppression, cardiovascular diseases, cancers. Recent studies show that exosomes transport specific microRNAs (miRNAs) are involved tumor development. However, the molecular mechanism by which invasion migration regulated from non-small cell lung cancer (NSCLC) is not well understood. Here, we shuttling low levels of miR-34c-3p NSCLC progression. Our results...
Allopurinol (ALP) attenuates oxidative stress and diabetic cardiomyopathy (DCM), but the mechanism is unclear. Activation of nuclear factor erythroid 2-related 2 (Nrf2) following disassociation with its repressor Keap1 under can maintain inner redox homeostasis attenuate DCM concomitant attenuation autophagy. We postulated that ALP treatment may activate Nrf2 to mitigate autophagy over-activation consequently DCM. Streptozotocin-induced type 1 rats were untreated or treated (100 mg/kg/d) for...
The current study presents a technique (navigated posterior lumbar fusion) which takes 5-cm incision to accomplish 2-level fusion (PLF) and compared its efficacy efficiency with those of conventional PLF. Forty patients who were indicated for included randomized either navigated PLF group or group. Blood loss, operation time, length, complications, bed rest period, length hospitalization recorded. Oswestry Disability Index (ODI) scoring was also performed each patient before surgery, 3...