A5051138604- Natural product bioactivities and synthesis
- Traditional Chinese Medicine Analysis
- Phytochemistry and Biological Activities
- Ginseng Biological Effects and Applications
- Chromatography in Natural Products
- Pharmacological Effects of Natural Compounds
- Phytochemical Studies and Bioactivities
- Plant-based Medicinal Research
- Phytochemicals and Antioxidant Activities
- Bioactive Natural Diterpenoids Research
- Food Quality and Safety Studies
- Bioactive natural compounds
- Sesquiterpenes and Asteraceae Studies
- Plant biochemistry and biosynthesis
- Metabolomics and Mass Spectrometry Studies
- Phytochemistry and biological activity of medicinal plants
- Biological and pharmacological studies of plants
- Traditional Chinese Medicine Studies
- Flavonoids in Medical Research
- Essential Oils and Antimicrobial Activity
- Autophagy in Disease and Therapy
- Fungal Biology and Applications
- Polysaccharides and Plant Cell Walls
- Ginger and Zingiberaceae research
- Medicinal plant effects and applications
Hong Kong Baptist University
2015-2024
Fujian Medical University
2024
Guangzhou Medical University
2020-2024
Mae Fah Luang University
2023
Chinese PLA General Hospital
2013-2020
South China Agricultural University
2020
Shanghai Entry-Exit Inspection and Quarantine Bureau
2017
Kowloon Hospital
2015
Chinese Academy of Medical Sciences & Peking Union Medical College
2014-2015
China Academy of Chinese Medical Sciences
2015
Abstract Oral decoctions of traditional Chinese medicines (TCMs) serve for therapeutic and prophylactic management diseases centuries. Small molecules polysaccharides are the dominant chemicals co-occurred in TCM decoction. well-studied by multidisciplinary elaborations, whereas role remains largely elusive. Here we explore a gut microbiota-involved mechanism which restore homeostasis microbiota consequently promote systemic exposure concomitant small As case study, ginseng ginsenosides...
Rhubarb is an important herbal medicine for the treatment of constipation, inflammation, and cancer. In this study, a facile method based on liquid chromatography coupled with electrospray ionization tandem mass spectrometry has been established analysis bioactive phenolic compounds in rhubarbs. From six rhubarb species, official (Rheum officinale, R. palmatum, tanguticum) unofficial (R. franzenbachii, hotaoense, emodi), total 107 were identified or tentatively characterized their spectra....
Processing of Chinese Materia Medica (CMM) is a pharmaceutical technique to fulfill the different requirements therapy, dispensing and making preparations according traditional medicine theory. The aims processing are enhance efficacy and/or reduce toxicity crude drugs. Those processed products named as decoction pieces, which used in clinics. Therefore, there close relationship between processing, safety, medicines. Some or side effects caused by improper methods some due combination herbal...
Arabidopsis thaliana seedlings undergo photomorphogenic development even in darkness when the function of DE-ETIOLATED1 (DET1), a repressor photomorphogenesis, is disrupted. However, mechanism by which DET1 represses photomorphogenesis remains unclear. Our results indicate that directly interacts with group transcription factors known as phytochrome-interacting (PIFs). Furthermore, our suggest positively regulates PIF protein levels primarily stabilizing proteins dark. Genetic analysis...
Abstract Exosomes play critical roles in regulating various physiological and pathological processes, including immune stimulation, suppression, cardiovascular diseases, cancers. Recent studies show that exosomes transport specific microRNAs (miRNAs) are involved tumor development. However, the molecular mechanism by which invasion migration regulated from non-small cell lung cancer (NSCLC) is not well understood. Here, we shuttling low levels of miR-34c-3p NSCLC progression. Our results...
Gastric cancer remains a major health problem worldwide. Natural products, with stronger antitumor activity and fewer side effects, are potential candidates for pharmaceutical development as anticancer agents. In this study, quercetin curcumin were chosen testing applied separately in combination to human gastric MGC-803 cells. The MTT assay was used evaluate cell growth inhibition. Annexin V-FITC/PI carried out measure apoptosis rate. Flow cytometry performed analyze mitochondrial membrane...
The abilities of a drug delivery system to target and penetrate tumor masses are key factors in determining the system's chemotherapeutic efficacy. Here, we explored utility an anti-carbonic anhydrase IX (anti-CA IX) antibody CPP33 dual-ligand modified triptolide-loaded liposomes (dl-TPL-lip) simultaneously enhance tumor-specific targeting increase cell penetration TPL. In vitro, dl-TPL-lip increased cytotoxicity TPL CA IX-positive lung cancer cells, which showed tunable size (137.6 ± 0.8...
Antibody-decorated liposomes can facilitate the precise delivery of chemotherapeutic drugs to lung by targeting a recognition factor present on surface tumor cells. Carbonic anhydrase IX (CA IX) is an enzyme expressed cancer cells with restricted expression in normal lungs. Here, we explored utility anti-carbonic antibody, conjugated triptolide (TPL)-loaded IX-TPL-Lips), promote therapeutic effects for via pulmonary administration. It was found that CA IX-TPL-Lips significantly improved...
Cancer stands as a prominent global cause of death. One the key reasons why clinical tumor chemotherapy fails is multidrug resistance (MDR). In recent decades, accumulated studies have shown how Natural Product-Derived Compounds can reverse MDR. Discovering novel potential modulators to reduce MDR by has become popular research area across globe. Numerous mainly focus on natural products including flavonoids, alkaloids, terpenoids, polyphenols and coumarins for their modulatory activity....
Dioscorea is a genus of flowering plants, and some species are known used as source for the steroidal sapogenin diosgenin. To screen potential resource from related medicinal plants diosgenin extraction, rapid method to compare contents in various crucial. An ultra-performance liquid chromatography (UPLC) coupled with diode array detection (DAD) electrospray ionization mass spectrometry (ESI-MS) was developed identification determination plants. A comprehensive validation conducted....
Perilla frutescens (L.) Britt. is not only an edible plant but also a traditional medicinal commonly used for treating common cold. It widely cultivated in southern China. The anatomical parts of P. that are recorded as medicines the Chinese material medica are: Perillae Caulis, Folium and Fructus, which dried stems, leaves ripe fruits, respectively. Rosmarinic acid one major polyphenolic ingredients found all three Fructus. characteristic volatile oil believed to be another essential...