A5100732247- Advancements in Semiconductor Devices and Circuit Design
- Semiconductor materials and devices
- Immune Cell Function and Interaction
- Gut microbiota and health
- T-cell and B-cell Immunology
- interferon and immune responses
- Epigenetics and DNA Methylation
- Nanowire Synthesis and Applications
- Immune cells in cancer
- Adsorption and biosorption for pollutant removal
- Natural product bioactivities and synthesis
- Integrated Circuits and Semiconductor Failure Analysis
- Advanced battery technologies research
- Biological Activity of Diterpenoids and Biflavonoids
- Plant Gene Expression Analysis
- Nanoparticle-Based Drug Delivery
- Neonatal Respiratory Health Research
- NF-κB Signaling Pathways
- Electrocatalysts for Energy Conversion
- Plant biochemistry and biosynthesis
- Nanomaterials for catalytic reactions
- Cynara cardunculus studies
- Travel-related health issues
- Fibroblast Growth Factor Research
- IL-33, ST2, and ILC Pathways
Harvard University
2019-2024
Chinese Academy of Sciences
2012-2024
Sinopec (China)
2024
University of Science and Technology Liaoning
2024
University of Science and Technology of China
2024
Boston VA Research Institute
2019-2023
Brigham and Women's Hospital
2021-2022
University of Chinese Academy of Sciences
2014-2022
Institute of Semiconductors
2013-2022
Jilin Academy of Agricultural Sciences
2022
Hepatocellular carcinoma (HCC) is frequently associated with pathogen infection–induced chronic inflammation. Large numbers of innate immune cells are present in HCCs and can influence disease outcome. Here, we demonstrated that the tumor suppressor serine/threonine-protein kinase 4 (STK4) differentially regulates TLR3/4/9-mediated inflammatory responses macrophages thereby protective against inflammation–associated HCC. STK4 dampened TLR4/9-induced proinflammatory cytokine secretion but...
The abilities of a drug delivery system to target and penetrate tumor masses are key factors in determining the system's chemotherapeutic efficacy. Here, we explored utility an anti-carbonic anhydrase IX (anti-CA IX) antibody CPP33 dual-ligand modified triptolide-loaded liposomes (dl-TPL-lip) simultaneously enhance tumor-specific targeting increase cell penetration TPL. In vitro, dl-TPL-lip increased cytotoxicity TPL CA IX-positive lung cancer cells, which showed tunable size (137.6 ± 0.8...
Caffeoylquinic acids and lignans in the crude extracts of both roots seeds from different burdock (Arctium lappa L.) genotypes were simultaneously characterized systematically compared by LC–MS matrix-assisted laser desorption/ionization quadrupole ion trap time-of-flight mass spectrometry (MALDI-QIT-TOF MS), their antioxidant activities also investigated. A total 14 identified 12 caffeoylquinic roots. High levels detected seeds, but only trace amounts found Burdock contained higher...
The architecture, size and density of metal oxide field effect transistors (MOSFETs) as unit bricks in integrated circuits (ICs) have constantly changed during the past five decades. driving force for such scientific technological development is to reduce production price, power consumption faster carrier transport transistor channel. Therefore, many challenges difficulties been merged processing which be dealed solved. This article highlights transition from 2D planar MOSFETs 3D fin...
Macrophages rapidly undergo glycolytic reprogramming in response to macroautophagy/autophagy, inflammasome activation and pyroptosis for the clearance of bacteria. Identification key molecules involved these three events will provide critical potential therapeutic applications. Upon S. typhimurium infection, FLT4/VEGFR3 its ligand VEGFC were inducibly expressed macrophages, FLT4 signaling inhibited CASP1 (caspase 1)-dependent but enhanced MAP1LC3/LC3 elimination Consistently, mutants lacking...
Abstract Sp, sp 2, or sp3 hybridization of carbon atoms results in linear, triangular, tetrahedral configuration bonding geometry, respectively. By combining different hybridizations one structure, a variety three-dimensional (3D) allotropes with periodic crystal structures can be obtained potential novel properties and applications. With the rapid development computational capability recent years, large number new 3D have been proposed their predicted; experimental techniques has also led...
The large parasitic resistance has become a critical limiting factor to on current (I <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">ON</inf> ) of FinFET and nanowire devices. Fully metallic source drain (MSD) process is one the most promising solutions but it often suffers from intolerant junction leakage in bulk FETs. In this paper, fully MSD fin-on-insulator (FOI) investigated extensively for first time. By forming Ni(Pt) silicide physically...
The electron mobility in a heavily n-doped junctionless nanowire transistor is demonstrated by the experimental investigation of transfer characteristics at low temperatures. It found that minimum critical temperature results from interplay thermal activation and impurity scattering. temperature-dependence tendency normalized theoretical calculation extraction reveals responsible for impact donor ionization energy on mobility.
Infection of rabies virus (RABV) causes central nervous system (CNS) dysfunction and results in high mortality human animals. However, it is still unclear whether how CNS inflammation immune response contribute to RABV infection.Suckling mice were intracerebrally infected with attenuated aG CTN strains, followed by examination chemokine or cytokine production, inflammatory cell infiltration neuron apoptosis the brain. Furthermore, suckling adult that intramuscularly street HN10 treated CCL5...
Plum ( Prunus salicina Lindl.) is one of the most widely cultivated and important fruit trees in temperate cold regions. Fruit color a significant trait relating to quality plum. However, its development mechanism has not been studied from aspects transcriptional regulation metabolomic progress. To reveal developments plums, we selected fruits two plum cultivars, ‘ Changli84 ’ (Ch84, red fruit) Dahuangganhe (D, yellow as plant materials for transcriptome sequencing analysis were performed....