A5010262316- Immune cells in cancer
- Olfactory and Sensory Function Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Autophagy in Disease and Therapy
- interferon and immune responses
- Immune Cell Function and Interaction
- Neurogenesis and neuroplasticity mechanisms
- Epigenetics and DNA Methylation
- Hepatitis C virus research
- Neuroscience and Neuropharmacology Research
- Neonatal Respiratory Health Research
- Natural Compounds in Disease Treatment
- Immune Response and Inflammation
- Pancreatic function and diabetes
- MicroRNA in disease regulation
- Metabolomics and Mass Spectrometry Studies
- Maritime Navigation and Safety
- Cell death mechanisms and regulation
- Underwater Vehicles and Communication Systems
- Alzheimer's disease research and treatments
- Cholesterol and Lipid Metabolism
- Cancer Immunotherapy and Biomarkers
- Biochemical Analysis and Sensing Techniques
- Circadian rhythm and melatonin
- Phagocytosis and Immune Regulation
Center for Excellence in Molecular Cell Science
2015-2024
University of Chinese Academy of Sciences
2019-2024
Xiamen University
2021-2024
Shanghai Tenth People's Hospital
2022-2024
Tongji University
2022-2024
Hangzhou City University
2023-2024
Zhejiang University
2014-2022
Shanghai Harbour Engineering Design & Research Institute
2022
Chinese Academy of Sciences
2015-2021
Shanghai Institutes for Biological Sciences
2015-2016
Inflammation, epithelial cell regeneration, macrophage polarization, and gut microbial homeostasis are critical for the pathological processes associated with inflammatory bowel disease (IBD). YAP (Yes-associated protein) is a key component of Hippo pathway was recently suggested to promote regeneration IBD recovery. However, it unclear how regulates inflammation, homeostasis. Although has been shown alleviate IBD, here we show that in macrophages aggravates accompanied by production...
Metabolomics is a powerful new technology that allows the assessment of global low-molecular-weight metabolites in biological system and which shows great potential biomarker discovery. Analysis key body fluids has become an important part improving diagnosis, prognosis, therapy diseases. Hepatitis C virus (HCV) major leading cause liver disease worldwide serious burden on public health. However, lack small-animal model hampered analysis HCV pathogenesis. We hypothesize animal (Tupaia...
Hepatocellular carcinoma (HCC) is frequently associated with pathogen infection–induced chronic inflammation. Large numbers of innate immune cells are present in HCCs and can influence disease outcome. Here, we demonstrated that the tumor suppressor serine/threonine-protein kinase 4 (STK4) differentially regulates TLR3/4/9-mediated inflammatory responses macrophages thereby protective against inflammation–associated HCC. STK4 dampened TLR4/9-induced proinflammatory cytokine secretion but...
The combination use of TGF-β, M-CSF, and IL-6 represents a promising therapy to repair traumatic brain injury.
Triptolide (TP), one of the major active components traditional Chinese herb Tripterygium wilfordii Hook F, and 2, 4-diamino-6-hydroxypyrimidine (DAHP), an inhibitor tetrahydrobiopterin (BH4) synthesis, have been reported to potent anti-inflammatory immunosuppressive properties. However, protective effects TP DAHP on cerebral ischemia not yet. In this study, we investigated neuroprotective in a middle artery occlusion (MCAO) rat model. Furthermore, examined whether were associated with...
Stroke is the leading cause of neurological disability in humans. Middle cerebral artery occlusion (MCAO) followed by reperfusion widely accepted to mimic stroke basic medical research. Triptolide one major active components traditional Chinese herb Tripterygium wilfordii Hook F, and has been reported have potent anti-inflammatory immunosuppressive properties. Since its preclinical effects on were still unclear, we decided study focal ischemia/reperfusion injury this study. The results...
Macrophages rapidly undergo glycolytic reprogramming in response to macroautophagy/autophagy, inflammasome activation and pyroptosis for the clearance of bacteria. Identification key molecules involved these three events will provide critical potential therapeutic applications. Upon S. typhimurium infection, FLT4/VEGFR3 its ligand VEGFC were inducibly expressed macrophages, FLT4 signaling inhibited CASP1 (caspase 1)-dependent but enhanced MAP1LC3/LC3 elimination Consistently, mutants lacking...
Significance Multiple human diseases including cancer and sepsis are closely related to uncontrolled inflammation. However, there is not much success for clinical therapy date by targeting specific inflammatory cytokines. Since NF-κB–mediated transactivation in the nucleus pivotal downstream of various stimuli induce inflammation, searching nuclear-localized targets specifically regulating NF-κB activation will provide important therapeutic application. This study has found that HIPK2...
It has previously been demonstrated that ischemic stroke activates autophagy pathways; however, the mechanism remains unclear. The aim of this study is to further investigate role plays in cerebral ischemia. 2, 4‐diamino‐6‐hydroxy‐pyrimidine (DAHP), for its nitric oxide synthase (NOS) inhibiting neuroprotective effect, and triptolide (TP), anti‐inflammatory property, were selected administer pre middle artery occlusion (MCAO). drugs administered 12 hours prior MCAO. Both magnetic resonance...
Detection of cytosolic nucleic acids by pattern recognition receptors, including STING and RIG-I, leads to the activation multiple signalling pathways that culminate in production type I interferons (IFNs) which are vital for host survival during virus infection. In addition protective immune modulatory functions, IFNs also associated with autoimmune diseases. Hence, it is important elucidate mechanisms govern their expression. this study, we identified a critical regulatory function DUSP4...
Research Article7 April 2015Open Access Source Data ADAP and SKAP55 deficiency suppresses PD-1 expression in CD8+ cytotoxic T lymphocytes for enhanced anti-tumor immunotherapy Chunyang Li Key Laboratory of Systems Biology, Institute Biochemistry Cell Shanghai Institutes Biological Sciences, Chinese Academy Shanghai, China Search more papers by this author Weiyun Jun Xiao Normal University, Shaozhuo Jiao Fei Teng Shengjie Xue Chi Zhang Chun Sheng Qibin Leng Pasteur Christopher E Rudd...
Type I interferons (IFNs) play both beneficial and harmful roles in antiviral responses. Precise regulation of host type IFNs is thus needed to prevent immune dysregulation. Here, we find that the DNA demethylase TET3 a negative regulator IFN-β response poly(I:C) stimulation or viral infection. Deletion enhances responses, with elevated expression IFN-stimulated genes. The catalytic domain was critical for suppression production, but enzymatic activity dispensable. Instead, interacts HDAC1...
Olfactory dysfunction is an early event in Alzheimer's disease (AD). However, the mechanism underlying AD-related changes olfactory bulb (OB) remains unknown. Granule cells (GCs) OB regulate activity of mitral (MCs) through reciprocal dendrodendritic synapses, which crucial for signal processing and odor discrimination. Nevertheless, relationships between morphological functional particularly local field potentials (LFPs) as a consequence disorders patients with AD have not been...
Growing evidence indicates the vital role of lipid metabolites in innate immunity. The lysophosphatidic acid (LPA) concentrations are enhanced patients upon HCV or SARS-CoV-2 infection, but function LPA and its receptors immunity is largely unknown. Here, we found that viral infection promoted G protein–coupled receptor LPA1 expression, restrained type I/III interferon production through LPA1. Mechanistically, signaling activated ROCK1/2, which phosphorylated IRF3 Ser97 to suppress...
Hepatocellular carcinoma (HCC) is a cancer lacking effective therapies. Several measures have been proposed to treat HCCs, such as senescence induction, mitotic inhibition, and cell death promotion. However, data from other cancers suggest that single use of these approaches may not be effective. Here, by genetic targeting Survivin, an inhibitor apoptosis protein (IAP) plays dual roles in mitosis survival, we identified tumor necrosis factor alpha (TNFα)-mediated synergistic lethal effect...