A5103867770- Autophagy in Disease and Therapy
- MicroRNA in disease regulation
- Histone Deacetylase Inhibitors Research
- Phagocytosis and Immune Regulation
- Adenosine and Purinergic Signaling
- Endoplasmic Reticulum Stress and Disease
- Adipokines, Inflammation, and Metabolic Diseases
- Membrane Separation Technologies
- Hereditary Neurological Disorders
- Circadian rhythm and melatonin
- Cannabis and Cannabinoid Research
- Water-Energy-Food Nexus Studies
- CRISPR and Genetic Engineering
- Ginseng Biological Effects and Applications
- Muscle activation and electromyography studies
- Advanced Materials and Mechanics
- Bacteriophages and microbial interactions
- Cancer-related Molecular Pathways
- Biomedical Research and Pathophysiology
- Cancer-related molecular mechanisms research
- Drug Transport and Resistance Mechanisms
- Additive Manufacturing and 3D Printing Technologies
- Ginkgo biloba and Cashew Applications
- Diet, Metabolism, and Disease
- Signaling Pathways in Disease
Zhejiang University
2015-2024
Zhejiang Ocean University
2024
Shanghai University of Sport
2023
Tianjin Medical University
2022
Chongqing Medical University
2018-2021
China Medical University
2020
Chenzhou First People's Hospital
2019
First Affiliated Hospital of Zhengzhou University
2019
Nanjing Agricultural University
2019
Harbin Medical University
2014-2018
De novo mutations in ATAD3A (ATPase family AAA-domain containing protein 3A) were recently found to cause a neurological syndrome with developmental delay, hypotonia, spasticity, optic atrophy, axonal neuropathy, and hypertrophic cardiomyopathy. Using whole-exome sequencing, we identified dominantly inherited heterozygous variant c.1064G > A (p.G355D) mother presenting hereditary spastic paraplegia (HSP) neuropathy her son dyskinetic cerebral palsy, both disease onset childhood. HSP is...
It has previously been demonstrated that ischemic stroke activates autophagy pathways; however, the mechanism remains unclear. The aim of this study is to further investigate role plays in cerebral ischemia. 2, 4‐diamino‐6‐hydroxy‐pyrimidine (DAHP), for its nitric oxide synthase (NOS) inhibiting neuroprotective effect, and triptolide (TP), anti‐inflammatory property, were selected administer pre middle artery occlusion (MCAO). drugs administered 12 hours prior MCAO. Both magnetic resonance...
Cholestasis is characterized by an abnormal accumulation of bile acids and causes hepatocellular injury. Recent studies show that autophagy involved in the pathophysiology many liver diseases. The potential role preventing cholestatic hepatotoxicity, however, has rarely been investigated. aim this study was to examine whether hepatotoxicity. We found duct ligation (BDL) led injury hepatocytic activation mice. Suppression with Chloroquine (CQ) increased hepatocytes apoptosis; while rapamycin...
Abstract: During the pathogenesis of early atherosclerosis, lipid-loaded macrophages are involved in plaque development and progression. As a novel adipokine, C1q/tumor necrosis factor–related protein-9 (CTRP9) has beneficial effects cardiovascular disease. However, previous reports have not studied whether formation macrophage foam cell induced by oxidized low-density lipoprotein (ox-LDL) is affected CTRP9. According to our study, ox-LDL–induced THP-1 macrophages, CTRP9 could reduce...
Dysfunction in survival and differentiation of osteoblasts commonly occurs patients with osteoporosis. Cannabinoid receptor type 2 (CNR2) is a major endocannabinoid system that crucial for bone mass homeostasis. Our group prior demonstrated activation CNR2 signaling promoted osteogenic marrow derived mesenchymal stem cells vitro. Autophagy reported to participate osteoblastic differentiation. Whether autophagy regulated by CNR2-mediated cannabinoid unknown, how the autophagy-CNR2 interaction...
Aluminum (Al) is a trivalent cation that can accumulate in animal organs, especially the liver. We previously demonstrated Al-overload could induce liver morphologic aberrations and dysfunction. However, molecular mechanism underlying injury caused by still remains unknown. In present study, we investigated relationship between leukotrienes receptors PI3K/AKT/mTOR pathway Al-induced vivo vitro. significantly increased protein expression levels of CysLTR1, PI3K, AKT, mTOR, p62, while...
Studies have reported mitophagy activation in renal tubular epithelial cells (RTECs) acute kidney injury (AKI). Phosphatase and tensin homolog-induced putative kinase 1 (PINK1) E3 ubiquitin-protein ligase Parkin are involved regulation; however, little is known about the role of PINK1-Parkin septic AKI. Here we investigated whether pathway AKI its effects on cell apoptosis vitro functions vivo.Mitophagy-related gene expression was determined using Western blot assay human RTEC line HK-2...
Prostaglandin D2 (PGD2) is the most abundant prostaglandin in brain, but its involvement brain damage caused by type 2 diabetes (T2D) has not been reported. In present study, we found that increased PGD2 content related to inhibition of autophagy, which aggravates T2D, and may be involved imbalanced expression corresponding receptors DP1 DP2. We demonstrated DP2 inhibited autophagy promotedT2D-induced activating PI3K/AKT/mTOR pathway, whereas DP1enhanced amelioratedT2D cAMP/PKA pathway. a...
Autophagy plays an important role in cell survival under diverse stress conditions. Here, we show that white LED light exposure for 24 h significantly activated autophagy-related genes and increased autophagosome formation hippocampal neural cells (HT-22). Concurrently, the rhythmic pattern of clock-related gene expression was disrupted, which associated with augmented SIRT1, AMPK retinoid-related orphan receptor alpha (RORα). SR1001, a specific inhibitor RORα, protected from light-induced...
Water shortage is one of the main issues affecting agricultural development in many regions, and problem crop yield reduction caused by salinisation irrigation water has become increasingly prominent. Xinjiang a major province China, with mostly remote land an unstable electricity supply. We have introduced combination photovoltaic reverse osmosis technology local Aksu region, using wastewater for to improve returns. In order verify feasibility two schemes, we evaluated benefits apple...
Adiponectin has been demonstrated to be a mediator of insulin sensitivity; however, the underlined mechanisms remain unclear. SESN2 is stress-inducible protein that phosphorylates AMPK in different tissues. In this study, we aimed validate amelioration resistance by globular adiponectin (gAd) and reveal role improvement glucose metabolism gAd. We used high-fat diet-induced wild-type SESN2-/- C57BL/6J mice model study effects six-week aerobic exercise or gAd administration on resistance....
It was revealed by our previous research that sodium selenite repressed autophagy accompanied the induction of apoptosis in human leukemia NB4 cells. The inhibition exerted a facilitative effect on apoptosis. In present study, we further explored mechanisms underlying switch from to and elucidated p53 played key role. Selenite induced phosphorylation at vital site Ser15 via p38MAPK ERK. Subsequently dissociated with its inhibitory protein mouse double minute 2 (MDM2). Meanwhile, nucleolar...
Abstract Because of its high precision and speed, stick-slip actuators in piezoelectric have important research significance aerospace other fields. To make the performance actuator superior, a high-performance suitable for field is developed. In this paper, based on in-depth study related theories, kind arc-plate flexible driving foot proposed. On basis, designed to further improve actuator. After test, maximum speed can reach 4.12 mm/s, load 330 g.
The aim of this study was to predict the kinase inhibitors that may regulate autophagy. A total 62 kinases were obtained through text mining by importing keyword 'autophagy' and a 'protein kinase' Excel file PubMed. Subsequently, 146 derivated screening in PubMed database 'autophagy‑associated gene' files. Following intersection above two methods, 54 candidate autophagy‑associated obtained. Enrichment analysis indicated these mainly enriched pathways such as calcium, Wnt, HIF‑1 mTOR...
To study the effect of calcitonin gene-related peptide (CGRP) on apoptosis and autophagy mouse MC3T3-E1 osteoblast their interaction to further clarify protective mechanism CGRP osteoblasts.MC3T3-E1 osteoblasts were cultured in vitro. Western blot flow cytometry used detect expressions microtubule-associated protein 1 light chain 3 (LC3) P62 with serum culture serum-free (serum starvation) culture. was also LC3 at different concentrations (10⁻¹⁰, 10⁻⁹, 10⁻⁸, 10⁻⁷ mol·L⁻¹) or without added...