A5037472498- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- interferon and immune responses
- Epigenetics and DNA Methylation
- Geotechnical Engineering and Underground Structures
- Immune cells in cancer
- Neonatal Respiratory Health Research
- Viral Infections and Immunology Research
- Geotechnical Engineering and Analysis
- Autophagy in Disease and Therapy
- Neuroscience of respiration and sleep
- Geotechnical Engineering and Soil Stabilization
- Immunotherapy and Immune Responses
- Receptor Mechanisms and Signaling
- Structural Health Monitoring Techniques
- Cell Adhesion Molecules Research
- Ion channel regulation and function
- Liver Disease Diagnosis and Treatment
- MicroRNA in disease regulation
- Pancreatic function and diabetes
- Stress Responses and Cortisol
- Muscle Physiology and Disorders
- Genetics and Neurodevelopmental Disorders
- Infrastructure Maintenance and Monitoring
Soochow University
2014-2025
First Affiliated Hospital of Soochow University
2014-2025
Sichuan University
2005-2025
West China Hospital of Sichuan University
2021-2025
China Guangzhou Analysis and Testing Center
2020-2025
Shanghai University
2015-2024
Qingdao University
2022-2024
Guangzhou Automobile Group (China)
2023-2024
Shanghai Jiao Tong University
2024
National Health and Family Planning Commission
2024
The coreceptor cytotoxic T lymphocyte–associated antigen 4 (CTLA-4) is pivotal in regulating the threshold of signals during cell activation, although underlying mechanism still not fully understood. Using vitro migration assays and vivo two-photon laser scanning microscopy, we showed that CTLA-4 increases motility overrides receptor (TCR)–induced stop signal required for stable conjugate formation between cells antigen-presenting cells. This event led to reduced contact periods turn...
Inflammation, epithelial cell regeneration, macrophage polarization, and gut microbial homeostasis are critical for the pathological processes associated with inflammatory bowel disease (IBD). YAP (Yes-associated protein) is a key component of Hippo pathway was recently suggested to promote regeneration IBD recovery. However, it unclear how regulates inflammation, homeostasis. Although has been shown alleviate IBD, here we show that in macrophages aggravates accompanied by production...
Abstract The low efficiency of reprogramming and genomic integration virus vectors obscure the potential application induced pluripotent stem (iPS) cells; therefore, identification chemicals cooperative factors that may improve generation iPS cells will be great value. Moreover, cellular mechanisms limit need to investigated. Through screening a chemical library, we found two reported upregulate E-cadherin considerably increase efficiency. Further study process indicated is upregulated...
A 16–18 m deep excavation for a metro station with in-plane dimensions of approximately 20 wide by 290 long was constructed using the cut-and-cover technique in soft clay Shanghai metropolitan area, which many high-rise buildings and utilities exist. To investigate performance this associated effect on adjacent utility pipelines, long-term comprehensive instrumentation program conducted during construction. Field observations included deflections diaphragm walls, vertical movements at wall...
It is uncertain whether amnioinfusion (infusion of saline into the amniotic cavity) in women who have thick meconium staining fluid reduces risk perinatal death, moderate or severe aspiration syndrome, both.We performed a multicenter trial which 1998 pregnant labor at 36 more weeks gestation had were stratified according to presence absence variable decelerations fetal heart rate and then randomly assigned standard care. The composite primary outcome measure was both.Perinatal both occurred...
Cancer progression is associated with alterations of intra- and extramedullary hematopoiesis to support a systemic tumor-promoting myeloid response. However, the functional specialty, mechanism, clinical relevance (EMH) remain unclear. Here, we showed that heightened splenic myelopoiesis in tumor-bearing hosts was not only characterized by accumulation precursors, but also profound early hematopoietic stem/progenitor cells (HSPCs). With distinct capability produce respond...
Hepatocellular carcinoma (HCC) is frequently associated with pathogen infection–induced chronic inflammation. Large numbers of innate immune cells are present in HCCs and can influence disease outcome. Here, we demonstrated that the tumor suppressor serine/threonine-protein kinase 4 (STK4) differentially regulates TLR3/4/9-mediated inflammatory responses macrophages thereby protective against inflammation–associated HCC. STK4 dampened TLR4/9-induced proinflammatory cytokine secretion but...
Based on field data, this study investigates responses of six pre-existing buildings to an adjacent 24.8–25.2 m deep subway station excavated by the covered semi-top-down method. During excavation 1 wide and 50.2–50.5 slurry trenches for diaphragm wall panels (i.e., walling), both shallow foundations developed noticeable settlements up 15 mm. Subsequent upper 15.9–17.7 thick soils inside pit only incurred limited building less than 10 mm, which contrasted sharply with remarkable...
The combination use of TGF-β, M-CSF, and IL-6 represents a promising therapy to repair traumatic brain injury.
Although cytotoxic T lymphocyte antigen-4 (CTLA-4) negatively regulates cell activation, the full range of functions mediated by this coreceptor has yet to be established. In study, we report surprising finding that CTLA-4 engagement soluble antibody or CD80 potently up-regulates function-associated antigen 1 (LFA-1) adhesion intercellular molecule-1 (ICAM-1) and receptor clustering concurrent with IL-2 inhibition. This effect was also observed ligation not other coreceptors. (TcR)-induced...
Neuroblasts produced by the neural stem cells of adult subventricular zone (SVZ) migrate into damaged brain areas after stroke or other injuries, and previous data have suggested that they generate regionally appropriate new neurons. To classify types neurons subsequent to ischemic injury, we combined BrdU virus labeling with multiple neuronal markers characterize at different times induction stroke. We show SVZ neuroblasts give rise almost exclusively calretinin-expressing in striatum,...
Abstract Background Adolescent acne impacts self‐esteem and quality of life in adolescents its aetiology is not fully clarified. Objective The aim this study was to describe the epidemiological features adolescent North East China determine impact genetic environmental factors on pathogenesis acne. Methods Data were collected from 5696 undergraduates (2920 patients 2776 controls) using questionnaire. survey data analysed spss version 13.0 heritability calculated Falconer’s method. Results...
Four metro stations with similar supporting systems and pit geometries in Shanghai soft clay were excavated using different soil removal procedures, which led to distinctly behaviors. Through analyzing comparing the well-documented field data from these four bottom-up excavations, significances of quick excavation, promptly propping, timely casting floor slabs, segmented construction control deformations identified their influences comprehensively quantified. As pits, measured time-dependent...
By analyzing the field data from nine metro-station pits with aspect ratios (AR) of pit length to width 6.6–19.4 in Shanghai soft clay, this paper investigates potential corner effects (i.e., retaining walls near corners have stronger capabilities resist deformation than those distant away as a product spatial arching across corners) long and narrow multipropped metro station excavations. Contrary two-dimensional (2D) plane-strain assumption widely adopted practice for analysis excavation...