A5101718861- Parasitic infections in humans and animals
- Aquatic Ecosystems and Phytoplankton Dynamics
- Congenital Anomalies and Fetal Surgery
- Sepsis Diagnosis and Treatment
- Acute Kidney Injury Research
- Marine and coastal ecosystems
- Extracellular vesicles in disease
- Marine Toxins and Detection Methods
- Biocrusts and Microbial Ecology
- Parasitic Infections and Diagnostics
- Antifungal resistance and susceptibility
- Computational Drug Discovery Methods
- Single-cell and spatial transcriptomics
- Phytochemistry and Biological Activities
- Cancer-related molecular mechanisms research
- Invertebrate Immune Response Mechanisms
- Antimicrobial Peptides and Activities
- MicroRNA in disease regulation
- Multiple Sclerosis Research Studies
- HIV/AIDS drug development and treatment
- Electrolyte and hormonal disorders
- Cardiac Arrest and Resuscitation
- Circular RNAs in diseases
- Neurological Disease Mechanisms and Treatments
- Ocular Diseases and Behçet’s Syndrome
Beijing Tongren Hospital
2022-2025
Capital Medical University
2022-2025
Jilin University
2013-2025
Second Affiliated Hospital of Jilin University
2014-2024
International Renal Research Institute of Vicenza
2018-2024
Henan Normal University
2021-2024
Henan Province Water Conservancy Survey and Design Research
2024
First Hospital of Shijiazhuang
2011-2024
Renmin University of China
2019-2024
Affiliated Hospital of North Sichuan Medical College
2016-2022
The new type of pneumonia caused by the SARS-CoV-2 (Severe acute respiratory syndrome coronavirus 2) has been declared as a global public health concern WHO. As April 3, 2020, more than 1,000,000 human infections have diagnosed around world, which exhibited apparent person-to-person transmission characteristics this virus. capacity vertical in remains controversial recently. Angiotensin-converting enzyme 2 (ACE2) is now confirmed receptor and plays essential roles infection transmission. In...
Single-cell RNA sequencing (scRNA-seq) can characterize cell types and states through unsupervised clustering, but the ever increasing number of cells batch effect impose computational challenges. We present DESC, an deep embedding algorithm that clusters scRNA-seq data by iteratively optimizing a clustering objective function. Through iterative self-learning, DESC gradually removes effects, as long technical differences across batches are smaller than true biological variations. As soft...
The R2R3-MYB proteins comprise one of the largest families transcription factors in plants. Although genome-wide analysis this family has been carried out some plant species, little is known about genes canola (Brassica napus L.). In study, we have identified 76 genome through mining expressed sequence tags (ESTs). cDNA sequences 44 MYB were successfully cloned. transcriptional activities BnaMYB encoded by these assayed yeast. subcellular localizations representative investigated GFP fusion....
Sepsis and secondary multiple organ failure in critically ill patients are the major cause of death, but pathogenesis sepsis is not clear, especially dysfunction immune system. In this paper, we review response regulation system functions a variety inflammatory mediators sepsis.Studies were identified by searching MEDLINE PubMed for articles using keywords "sepsis", "immune response", "inflammatory mediator" up to October 2010. Additional papers manual search references from key...
Annually, tens of millions first-ever strokes occur in the world; however, currently there is lack effective and widely applicable pharmacological treatments for stroke patients. Herbal medicines, characterized as multi-constituent, multi-target multi-effect, have been acknowledged with conspicuous effects treating stroke, attract extensive interest researchers although mechanism action yet unclear. In this work, we introduce an innovative systems-pharmacology method that combines...
CDK2, which interacts with cyclin A and E, is an important member of the CDK family. Having been proved to be associated many diseases for its vital role in cell cycle, CDK2 a promising target anti-cancer drugs dealing cycle disorders. In present work, total 111 pyrazolo[1,5-a]pyrimidines (PHTPPs) as CDK2/cyclin inhibitors were studied conduct three-dimensional quantitative structure–activity (3D-QSAR) analyses. The optimal comparative molecular similarity indices analysis (CoMSIA) model...
Echinococcosis is a serious zoonotic parasitic disease that highly endemic in Qinghai Province. The present study aimed to investigate the prevalence of echinococcosis among schoolchildren Golog Tibetan Autonomous Prefecture improve early diagnosis and treatment patients provide information for prevention control. A total 11,260 from five counties (Maqin, Gander, Dari, Jiuzhi, Banma) Prefecture, Province, were screened echinococcosis. Screening involved ultrasound imaging combined with...