A5100727567- Microbial Natural Products and Biosynthesis
- Tea Polyphenols and Effects
- Ginger and Zingiberaceae research
- Fungal Biology and Applications
- Plant biochemistry and biosynthesis
- Phytochemistry and Biological Activities
- Chemical synthesis and alkaloids
- Phytochemicals and Antioxidant Activities
- Tryptophan and brain disorders
- Computational Drug Discovery Methods
- Mangiferin and Mango Extracts
- Phytochemical compounds biological activities
- Drug Transport and Resistance Mechanisms
- Pelvic and Acetabular Injuries
- Estrogen and related hormone effects
- Flavonoids in Medical Research
- Pharmacological Effects of Natural Compounds
- Microbial Metabolic Engineering and Bioproduction
- Advanced Glycation End Products research
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Cancer-related Molecular Pathways
- Alkaloids: synthesis and pharmacology
- Traditional Chinese Medicine Analysis
- Spinal Fractures and Fixation Techniques
Kunming Medical University
2020-2025
First Affiliated Hospital of Zhengzhou University
2025
Second Military Medical University
2024
Changhai Hospital
2024
Tsinghua–Berkeley Shenzhen Institute
2024
Tsinghua University
2024
Utah State University
2013-2023
North Carolina Agricultural and Technical State University
2018-2023
Center for Excellence in Education
2023
Chinese Academy of Sciences
2007-2022
As the landscape of higher education continues to evolve, institutions must adapt meet changing needs prospective graduate students. This article explores implications student-centered strategies on academic and personal growth science The traditional teacher-centered approach, while effective in conveying foundational knowledge, has been criticized for hindering development critical thinking, creativity, problem-solving skills. In contrast, approach shifts focus learners, encouraging active...
Multi-components Traditional Chinese Medicine (TCM) treats various complex diseases (multi-etiologies and multi-symptoms) via herbs interactions to exert curative efficacy with less adverse effects. However, the ancient compatibility theory of formula still remains ambiguous. Presently, this combination principle is dissected through a systems pharmacology study on mechanism action representative TCM formula, Huo-xiang-zheng-qi (HXZQ) prescription, treatment functional dyspepsia (FD),...
A crucial step during the programmed biosynthesis of fungal polyketide natural products is release final intermediate from iterative synthases (iPKSs), most frequently by a thioesterase (TE) domain. Realization combinatorial with iPKSs requires TE domains that can accept altered intermediates generated hybrid synthase enzymes and successfully "unnatural products" desired structure. Achieving precise control over product paramount importance O-C bond-forming capable macrocyclization,...
Abstract Polymeric nanocarriers have a broad range of clinical applications in recent years, but an inefficient delivery polymeric to target tissues has always been challenge. These results show that tuning the elasticity hydrogel nanoparticles (HNPs) improves their efficiency tumors. Herein, microfluidic system is constructed evaluate cellular uptake HNPs different under flow conditions. It found soft are more efficiently taken up by cells than hard conditions, owing greater adhesion...
Neohesperidin dihydrochalcone (NHDC) is a safe and widely used sweetener from citrus hesperidin. Beyond its sweetening properties, the potential health benefits mechanisms of NHDC remain underexplored. This study investigated whether could reduce lipid peroxidation through microbial metabolite, hesperetin (HDC), which traps 4-hydroxynonenal (4-HNE), reactive carbonyl species generated during peroxidation. In vitro, HDC formed covalent conjugates with 4-HNE 1,2-addition at aldehyde site...
Abstract Nonribosomal peptide synthetases (NRPSs) assemble a large group of structurally and functionally diverse natural products. While the iterative catalytic mechanism bacterial NRPSs is known, it remains unclear how fungal create products desired length. Here we show that adopt an alternate incorporation strategy. Beauvericin bassianolide have same C 1 -A -T -C 2 -MT-T 2a 2b 3 domain organization. During catalysis, take turns to incorporate two biosynthetic precursors into growing...
Trapping of methylglyoxal (MGO) has been determined to be one the potential mechanisms for dietary polyphenols prevent chronic diseases. In this study, myricetin was demonstrated efficiently trap MGO generate mono- and di-MGO adducts under in vitro conditions. Furthermore, were detected urine fecal samples collected from myricetin-treated mice based on LC–MS analysis. More importantly, mono-MGO di-methylated also found these mouse samples. Further dose-dependent studies that its methylated...
Ginger contain bioactive compounds that possess anti-inflammatory and antimicrobial properties. In this study, 432-day-old Ross 708 broiler male chicks were randomly allocated to six dietary treatments investigate the effect of ginger root extract (GRE) on immunocompetence growth performance 6 wk age. Treatment 1 (CON) consisted fed a corn-soybean meal (SBM), base diet without GRE. 2 (MX) given basal diets containing bacitracin methylene disalicylate (BMD) at 0.055 g/kg. Treatments 3...
CDK2, which interacts with cyclin A and E, is an important member of the CDK family. Having been proved to be associated many diseases for its vital role in cell cycle, CDK2 a promising target anti-cancer drugs dealing cycle disorders. In present work, total 111 pyrazolo[1,5-a]pyrimidines (PHTPPs) as CDK2/cyclin inhibitors were studied conduct three-dimensional quantitative structure–activity (3D-QSAR) analyses. The optimal comparative molecular similarity indices analysis (CoMSIA) model...
Consumption of black tea contributed to many health benefits including the prevention heart disease and certain types cancer. However, chemical composition has not been fully explored. Most studies have examined different interactions between four major catechins, limited investigated interaction catechins other components in tea. In present study, we tested our hypothesis that ortho-dihydroxyl structure chlorogenic acid (CGA) could react with vic-trihydroxy (-)-epigallocatechin 3-gallate...
Abstract Therapeutic targeting of KRAS-mutant pancreatic ductal adenocarcinoma (PDAC) has remained a significant challenge in clinical oncology. Direct KRAS proven difficult, and inhibition the effectors have shown limited success due to compensatory activation survival pathways. Being core downstream effector KRAS-driven p44/42 MAPK PI3K/AKT pathways governing intrinsic apoptosis, BAD phosphorylation emerges as promising therapeutic target. Herein, positive association pBADS99/BAD ratio...
A biosynthetic pathway to fungal polyketide–nonribosomal peptide natural products, Sch210971 (1a) and Sch210972 (1b) from Hapsidospora irregularis, was characterized by reconstitution heterologous expression in Fusarium heterosporum. Using genetic, biochemical, feeding experiments, we show that the incorporated amino acid 4-hydroxyl-4-methyl glutamate (HMG) is synthesized an aldolase, probably using pyruvate as precursor.
Abstract Objective To compare the biomechanical stability of transsacral-transiliac screw fixation and lumbopelvic for “H”- “U”-type sacrum fractures with traumatic spondylopelvic dissociation. Methods Finite element models dissociation were created in this study. The mimicked standing position a human. Fixation fixation, bilateral triangular simulated. Biomechanical tests instability performed, fracture gap displacement, anteflexion, rotation, stress distribution after assessed. Results For...
6-Gingerol and 6-shogaol are the most abundant gingerols shogaols in ginger root have been shown to reduce asthmatic phenotype murine models of asthma. Several studies described pharmacokinetics humans following oral ingestion ginger, while little was known about metabolism these components humans, particularly patients with In this study, a dietary supplement 1.0 g extract administered asthma twice daily for 56 days serum samples were drawn at 0.5–8 h on 0, 28, 56. The metabolic profiles...