A5100420996- Ferroptosis and cancer prognosis
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Cancer-related molecular mechanisms research
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Research Studies
- Gastric Cancer Management and Outcomes
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Brain Metastases and Treatment
- Neonatal Respiratory Health Research
- Pulmonary Hypertension Research and Treatments
- Glioma Diagnosis and Treatment
- Renal cell carcinoma treatment
- Gastrointestinal Tumor Research and Treatment
- Medical Imaging Techniques and Applications
- Cancer Immunotherapy and Biomarkers
- Respiratory Support and Mechanisms
- Cancer Genomics and Diagnostics
- Cancer, Lipids, and Metabolism
- Congenital Diaphragmatic Hernia Studies
- Renal and related cancers
- Advanced MRI Techniques and Applications
- Selenium in Biological Systems
- Colorectal Cancer Surgical Treatments
Zhengzhou University
2021-2025
Changzhi Medical College
2016-2025
Kunming Medical University
2023-2025
Guangdong 999 Brain Hospital
2016-2024
Huazhong University of Science and Technology
2024
Hubei Cancer Hospital
2024
Ministry of Education of the People's Republic of China
2011-2024
Shandong First Medical University
2024
Shandong Tumor Hospital
2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2023
Inhibition of ferroptosis in intestinal epithelial cells ameliorates clinical symptoms and improves endoscopic presentations inflammatory bowel disease (IBD). Licorice is used worldwide food medicine fields. Liquiritin, a flavonoid component licorice, an effective substance as anti-inflammatory, antioxidant that has been shown to improve chemically induced colitis. Herein we evaluated the therapeutic effects liquiritin on colitis determined whether could affect by modulating cells. A model...
Shaoyao Decoction (SYD) is a canonical herbal medicine prescription formulated by Liu Wan-Su in AD 1186. SYD has been widely used to treat inflammatory bowel disease clearing heat and damp, removing stasis toxin the intestine; however, precise mechanisms therapeutic material basis remain largely unclear. In present study, we measured effects of on colitis symptom, epithelial barrier function, ferroptosis, colonic protein mRNA expression glutathione peroxidase 4 (GPX4) model, determined...
Paclitaxel-based chemotherapy represented by nanoparticle albumin-bound paclitaxel (nab-ptx) combined with programmed cell death protein 1 (PD-1)/programmed ligand (PD-L1) inhibitors has become the standard model for 1st treatment of advanced non-small lung cancer (NSCLC) negative driver genes (such as EGFR, ALK, etc.), indicating that nab-ptx and PD-1/PD-L1 are synergistic. Considering alone or single limited efficiency in 2nd line above NSCLC, so it is great significance to explore...
The goal of this study was to create a nomogram using routine parameters predict leptomeningeal metastases (LMs) in advanced lung adenocarcinoma (LAC) patients prevent needless exams or lumbar punctures and assist accurately diagnosing LMs.
Pulmonary arterial hypertension (PAH) is a life-threatening disease characterized by sustained rise in mean pulmonary artery pressure. vascular remodeling serves an important role PAH. Identifying key driver gene to regulate of the microvasculature critical for PAH management.Differentially expressed genes were identified using Gene Expression Omnibus (GEO) GSE117261, GSE48149, GSE113439, GSE53408 and GSE16947 datasets. A co-expression network was constructed weighted analysis. Novel...
Despite its excellent therapeutic efficacy, albumin-bound paclitaxel often leads to peripheral neurotoxicity, significantly affecting patients' quality of life. This study reported a case non-small cell lung cancer (NSCLC) with neurotoxicity induced by paclitaxel.
Background: Microchromosome maintenance protein 10 (MCM10) is required for DNA replication in all eukaryotes, and it plays a key role the development of many types malignancies. However, we currently still do not know relationship between MCM10 ovarian cancer (OV) prognosis immune checkpoints. Methods: The Gene Expression Profiling Interactive Analysis Tumor Immunology Estimation Resource (TIMER) databases were used to investigate expression Fan cancer. Kaplan-Meier Plotter PrognoScan assess...
It is well-known that genomic mutational analysis plays a significant role in patients with NSCLC for personalized treatment. Given the increasing use of stereotactic radiosurgery (SRS) brain metastases (BM), there an emerging need more precise assessment survival outcomes after SRS. Patients BM and treated by SRS were eligible this study. The primary endpoint was overall (OS). Cox regression models used to identify independent prognostic factors. A predictive nomogram developed evaluated...
Background: Adenosquamous carcinoma (ASC) is a rare and aggressive histologic subtype of non-small cell lung cancer (NSCLC). Little known about the prognostic significance routine immunohistochemical (IHC) markers clinical value adjuvant radiotherapy in completely resected ASC. Methods: Consecutive patients with pathologically confirmed ASC receiving curative resection from January 2007 to December 2017 at our center were retrospectively reviewed. The 14 IHC potential candidate investigated....
Stereotactic radiosurgery (SRS) is a widely used therapy for brain metastases(BMs) in Non-small cell lung cancer(NSCLC). However, its role symptomatic patients with EGFR mutation remains unclear. We have retrospectively reviewed the clinical data of BMs whom received SRS as salvage approach and concurrent gifitinib therapy.Seven primary NSCLC, BMs, were identified retrospective review treated using X-knife at Guangdong 999 Brain Hospital between 1 January 2012 31 August 2014. The median...
Colorectal cancer (CRC) with brain metastases (BM) is uncommon and often diagnosed at a late stage. The aims of this study were to identify the clinical factors that can influence incidence CRC patients BM (CRCBM) investigate impact therapies on outcomes CRCBM.Between 2010 2018, CRCBM enrolled under Surveillance, Epidemiology, End Results (SEER) program. Multivariable logistic Cox regression models used risk prognostic BM. Kaplan-Meier curve log-rank test evaluate overall survival (OS)...
Abstract Background Chemotherapy combined with immune checkpoint inhibitors (IC), bevacizumab (BC), or both (IBC) is the preferred first-line therapy for PD-L1-negative and oncogenic-driver wild-type metastatic lung adenocarcinoma. However, optimal strategy still undetermined. Methods This retrospective study enrolled adenocarcinoma patients from four cancer centers between January 1, 2018 June 30, 2022. All received IC, BC, IBC as therapies. The efficacy safety were evaluated. Results A...