A5040973585- Nutrition and Health in Aging
- Adipose Tissue and Metabolism
- Body Composition Measurement Techniques
- Adipokines, Inflammation, and Metabolic Diseases
- Pain Mechanisms and Treatments
- Coagulation and Flocculation Studies
- Cardiovascular Disease and Adiposity
- Biomarkers in Disease Mechanisms
- Diabetes and associated disorders
- Diet, Metabolism, and Disease
- Neuropeptides and Animal Physiology
- RNA Research and Splicing
- Cannabis and Cannabinoid Research
- RNA modifications and cancer
- Muscle metabolism and nutrition
- Water Quality and Pollution Assessment
- HIV-related health complications and treatments
- MRI in cancer diagnosis
- Cancer, Lipids, and Metabolism
- Regulation of Appetite and Obesity
- Mitochondrial Function and Pathology
- Diet and metabolism studies
- Thermoregulation and physiological responses
- Smart Agriculture and AI
- Metabolism and Genetic Disorders
Air Force Medical University
2023-2025
Qilu Hospital of Shandong University
2016-2025
Carnegie Mellon University
2024
Shandong University
2008-2024
Zhengzhou University
2021-2024
Welspun (India)
2024
Zhejiang Shuren University
2023
Qingdao University
2021-2023
Affiliated Hospital of Qingdao University
2022-2023
Guangxi University
2023
The body temperature is considered a universal cue by which the master clock synchronizes peripheral clocks in mammals, but mechanism not fully understood. Here we identified two cold-induced RNA-binding proteins (RBPs), Cirbp and Rbm3, as important regulators for entrained circadian gene expression. depletion of or Rbm3 significantly reduced amplitudes core genes. PAR-CLIP analyses showed that 3′UTR binding sites were enriched near polyadenylation (PASs). Furthermore, shortened 3′UTR,...
Objective Irisin, a recently identified myokine, is involved in the protection of mice against obesity and diabetes. This study aims to determine serum vitreous concentrations irisin patients with diabetic nephropathy retinopathy. Methods A total 178 type 2 diabetes mellitus, as well 22 mellitus without retinopathy 35 proliferative were enrolled this study. Results Serum significantly elevated control group compared those patients. Furthermore, macroalbuminuria exhibited lower than controls...
Asprosin is a newly discovered adipokine. A recent study showed that asprosin promoted the β-cell apoptosis of MIN6 cells. This aims to determine whether induces in via regulating autophagy. Mouse insulinoma cells were divided into following four groups: control, vehicle, high glucose, and groups. group transfected with recombinant asprosin-T2A-GFP vector. vehicle vector only. Then was detected using flow cytometry. Real-time polymerase chain reaction western blot used expression caspase 3,...
Objective. Adropin is a newly identified regulatory protein encoded by the Enho gene and critically involved in energy homeostasis insulin sensitivity. This study aims to determine correlation of serum adropin concentrations with diabetic nephropathy (DN). Methods. consisted 245 patients type 2 diabetes mellitus (T2DM) 81 healthy subjects. Then T2DM were divided into normoalbuminuria, microalbuminuria, macroalbuminuria subgroups based on urine albumin creatinine ratio (ACR). Results. showed...
Abstract Objective The adipokine asprosin, which was recently discovered, facilitates hepatic glucose production. aim of this study is to see whether serum asprosin concentrations are linked diabetic nephropathy (DN). Methods We performed investigation in a group 212 type 2 diabetes (T2DM) patients. These patients were classified into three subgroups: DN0 (normal mildly increased), DN1 (moderately and DN2 (severely increased) on the basis urine albumin-to-creatinine ratio (ACR). Results When...
Abstract Objective Triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) ratio is correlated with metabolic diseases. The prevalence of sarcopenia significantly higher in type 2 diabetes mellitus (T2DM) patients compared healthy controls. purpose our study to evaluate the correlation TG/HDL-C muscle mass T2DM patients. Method Our consists 1048 inpatients recruited from department endocrinology. Skeletal index (SMI) was detected a dual energy X-ray absorptiometry method. Low diagnosed...
MicroRNAs (miRNAs) are 19- to 25-nucleotide-long small and noncoding RNAs now well-known for their regulatory roles in gene expression through posttranscriptional translational controls. Mammalian hibernation is a physiological process involving profound changes set-points food consumption, body mass growth, temperature, metabolic rate which miRNAs may play important roles. In an initial study, we analyzed the liver of extreme hibernating species, Arctic ground squirrel (Spermophilus...
Meteorin-like (Metrnl) is a newly discovered myokine. Plasma Metrnl decreased in subjects with diagnosed type 2 diabetes (T2D) and correlated insulin resistance. This study aims to determine the effects of on apoptosis proliferation β cell. Mouse insulinoma MIN6 cells were divided into six groups: normal control, low glucose, high Vehicle, Metrnl, Dickkopf 1 (DKK1) groups. group transfected recombinant pCDH-Metrnl vector. WNT/β-catenin pathway was inhibited using DKK1. Then detected flow...
Adropin, a newly identified regulatory protein encoded by Enho gene, is correlated with insulin sensitivity and diabetes. The aim of this study to determine whether serum vitreous adropin concentrations are the presence diabetic retinopathy.A population 165 patients type 2 diabetes mellitus (52 without retinopathy, 69 non-proliferative retinopathy 44 proliferative retinopathy) was enrolled in study. control group 68 healthy subjects who had underwent vitrectomy for retinal detachment. Serum...
The C-C motif chemokine ligand 2 (CCL2) has been implicated in chronic pain, but its exact mechanism of peripheral sensitization is unknown. In this study, we aimed to clarify the CCL2 regulation ion channels. Our behavioral experiments revealed that ZD7288, a blocker Ih current, can inhibit CFA and CCL2-mediated mechanical thermal nociceptive sensitization. Furthermore, patch clamp studies demonstrated CFA-induced primarily affects excitability small-diameter DRG neurons. Further...
<title>Abstract</title> Introduction: A higher risk of low muscle mass with type 2 diabetes mellitus (T2DM). Our study aimed to evaluate the association serum Mg in T2DM patients. Methods This included 1074 patients, skeletal index (SMI) and level were measured, other clinical data collected. Logistic regression analysis linear used determine associations between or SMI. Results The prevalence was 20.28% males 14.20% females, respectively. There a negative correlation SMI females after...
Patients with chronic pain often experience an exacerbated response and complain of memory deficits. However, the mechanistic link between cognitive function remains unclear. The dorsal hippocampus (dHPC), a well-defined region responsible for learning memory, displays maladaptive plasticity upon injury, which involves activation N-methyl-d-aspartic acid receptors. Mounting evidence has shown that cyclic guanosine cGMP-dependent protein kinase I (PKG-I) serves as key downstream target...
Cardiovascular and cerebrovascular diseases have become leading causes of death in China as the economy develop lifestyles change. This study aimed to estimate relationship age, gender, glucose metabolism with serum lipid lipoprotein levels middle-aged elderly Chinese men women Shandong Province.We conducted a cross-sectional Province that included 10,028 adults aged ≥40 years. Fasting total, low-density (LDL), high-density (HDL) cholesterol triglycerides were measured by standard...
The CRISPR/Cas9 system is a powerful tool for genome editing, in which the sgRNA binds and guides Cas9 protein sequence-specific cleavage. protocol employable different organisms, but often limited by cell damage due to endonuclease activity of introduced potential off-target DNA cleavage from incorrect guide 20 nt spacer. In this study, after resolving some critical limits, we have established an efficient deletion large fragments related biosynthesis secondary metabolites Myxococcus...
Blueberries are widely planted because of their rich nutritional value. Due to the problems dense adhesion and serious occlusion blueberries during growth process, development automatic blueberry picking has been seriously hindered. Therefore, using deep learning technology achieve rapid accurate positioning in case is one key technologies blueberries. To improve accuracy, this paper designs a recognition model based on improved YOLOv5. Firstly, dataset constructed. On basis, we design new...