A5100324187- Cholangiocarcinoma and Gallbladder Cancer Studies
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Gallbladder and Bile Duct Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Ruminant Nutrition and Digestive Physiology
- Esophageal and GI Pathology
- MicroRNA in disease regulation
- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- Traffic and Road Safety
- Circular RNAs in diseases
- Helicobacter pylori-related gastroenterology studies
- Tracheal and airway disorders
- Cancer-related Molecular Pathways
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cancer, Lipids, and Metabolism
- Genetic Associations and Epidemiology
- Metastasis and carcinoma case studies
- Colorectal Cancer Screening and Detection
- Cancer, Hypoxia, and Metabolism
- Microwave Engineering and Waveguides
- Peroxisome Proliferator-Activated Receptors
- Cerebrovascular and Carotid Artery Diseases
- Autophagy in Disease and Therapy
Second Affiliated Hospital of Nanjing Medical University
2016-2025
Kunming Medical University
2023-2025
Yangzhou University
2016-2025
Massachusetts General Hospital
2024-2025
Second Affiliated Hospital of Zhejiang University
2024-2025
Guangdong Academy of Medical Sciences
2024-2025
Southern Medical University
2024-2025
Guangdong Provincial People's Hospital
2024-2025
Central South University
2021-2024
China Automotive Technology and Research Center
2016-2024
p53 is a major tumor suppressor whose function pivotal for protection against cancer. In over half of human cancers, inactivated due to either point mutation or loss gene. It has been well established that in addition abrogating the tumor-suppressive wild-type p53, mutant gains new functions and actively contributes various stages progression. However, little known about whether microRNA (miRNA) involved gain-of-function p53. Here we report miR-27a as novel downstream transcriptional target...
Objective: Traffic deaths involving e-bike (electric bike) riders are increasing in China. This study aims to quantitatively investigate the association between rider casualty and impact speed electric bike-passenger vehicle collisions based on China in-depth accident data.Methods: According collision location driving direction of vehicle, divided into five types: frontal collision, side scrape rear-end collision. Since (the impacted with front vehicle) is leading type has highest likelihood...
Automatic emergency braking (AEB) system play an essential role in avoiding traffic collisions and minimizing impact strengths, which contributes to improving road safety. However, the present research of AEB is mainly concentrated on car pedestrian collisions. China has typical mixed characteristics, especially frequent two-wheeler collision accidents. Research prevent complex multi-traffic scenarios great significance further improve comprehensive performance system. In this article, based...
Abstract Objective Human immunodeficiency virus (HIV)-infected individuals who abuse methamphetamine (METH) exhibit more severe neurotoxicity and cognitive impairment. Pyroptosis, a programmed cell death pathway mediated by the inflammasome, has been implicated in various neurological diseases. This study aimed to elucidate role of AIM2 inflammasome METH- HIV-1 Tat-induced pyroptosis human brain tissue vitro models. Methods Postmortem from HIV-infected with history METH was analyzed for...
In this paper, we extend the idea of using mosaicked color filter array (CFA) in imaging, which has been widely adopted digital camera industry, to use multispectral (MSFA) imaging. The technique can help reduce cost, achieve exact registration, and improve robustness imaging system. However, extension from CFA MSFA is not straightforward. First, most CFAs only deal with a few bands (3 or 4) within narrow visual spectral region, while design needs handle arrangement multiple (more than 3)...
Cholangiocarcinoma (CCA) is the most common biliary tract malignancy, with a low survival rate and limited treatment options. Long non-coding RNAs (lncRNAs) have recently been verified to significant regulatory functions in many kinds of human cancers. It was discovered this study that lncRNA PVT1, whose expression significantly elevated CCA, could be molecular marker CCA. Experiments indicated PVT1 knockdown greatly inhibited cell migration proliferation vitro vivo. According RNA sequencing...
Lipid metabolism is important for cellular energy homeostasis. Excessive lipid accumulation associated with various human diseases such as obesity, cardiovascular disease or even cancer. It has been recognized that miR-181a an modulator in regulating T lymphocyte differentiation, vascular development and cerebellar neurodegeneration. Here we reports a novel function of the regulation metabolism. MiR-181a able to target isocitrate dehydrogenase 1 (IDH1), metabolic enzyme TCA cycle. Via...
This paper constructs an evaluation system that reflects dangerous driving behavior. The has a three-layer structure model of “Evaluation Index-Performance Mode-Driving behavior score.” Verification the feasibility based on relationship between driver and cause accident behavioral characteristics. First, return survey data form information real traffic cases China In-Depth Accident Study (CIDAS) database are counted, character variables converted into digital variables. Then, three-tier is...
Substance P contributes to the pathogenesis of pain by acting on NK-1R, specialized sensory neurons that detect noxious stimuli. Aprepitant, an antagonist is widely used treat chemotherapy-induced nausea and vomiting. In this study, we LPS-stimulated BV-2 microglia cell line animal models inflammatory explore analgesic effect aprepitant its underlying mechanism. The excitability DRG were measured using whole-cell patch-clamp recordings. behavioral tests morphological changes inflamed paw...
Associations of gaseous air pollutants (including carbon monoxide, sulfur dioxide, nitrogen and ozone) with asthma hospitalization, stratified by sex socioeconomic status, were examined among children 6–12 years age in Vancouver, British Columbia, Canada, between 1987 1998. Relative risks for an exposure increment corresponding to the interquartile range each pollutant estimated hospitalization after adjustment weather conditions, including daily maximum minimum temperatures as well average...
// Xianxiu Ge 1, * , Youli Wang 2, Junjie Nie Quanpeng Li Lingyu Tang 1 Xueting Deng Fei Boming Xu Xiaochao Wu Xiuhua Zhang Qiang You 3 and Lin Miao Institute of Digestive Endoscopy Medical Center for Diseases, Second Affiliated Hospital Nanjing University, Nanjing, China 2 Department Clinical Laboratory, First Hospital, Biotherapy, These authors have contributed equally to this work Correspondence to: Miao, email: miaolinxh@163.com Keywords: cholangiocarcinoma, exosome, long non-coding...
Bypass signaling activation plays a crucial role in the acquired resistance of gefitinib, first targeted drug clinic to treat advanced non-small cell lung cancer. Although inactivation bypass by small-molecule inhibitors or monoclonal antibodies may overcome gefitinib resistance, their clinical use has been limited complex production process and off-target toxicity. Here we show CuS nanoparticles (NPs) behaved as photodynamic nanoswitch specifically abrogate overactive resistant tumor cells...
Recently, long noncoding RNAs (lncRNAs) have been shown to play significant regulatory roles in human tumorigenesis. However, the biological function of lncRNAs cholangiocarcinoma (CCA) remains largely unknown. In this study, DANCR was be significantly upregulated CCA. regulated proliferation and migration CCA cells vitro. Moreover, downregulation suppressed vivo. RNA-seq revealed that knockdown preferentially affected genes linked with cell differentiation. Furthermore, mechanistic...
Abstract Cholangiocarcinoma (CCA) is the as most frequently observed biliary tract malignancy, which has low survival rate in addition to constrained treatment options; nevertheless, fundamental molecular phenomenon underlying malignant progression of CCA quite ambiguous. Recently long non-coding RNAs (lncRNAs) have been found significant regulatory functions several human cancers. Herein, we figured out that lncRNA SNHG1 , with substantially enhanced expression CCA, capable acting oncogenic...
Colorectal cancer (CRC) is the fourth leading cause of cancer-related mortality globally. Therefore, a better understanding early molecular events this disease needed. Long noncoding RNAs (lncRNAs) play critical role in regulation tumorigenesis and progression. In study, we investigated characteristics ZFAS1 CRC. We analyzed three independent microarray datasets CRC tissues from GEO found that expression was remarkably upregulated all datasets. Moreover, validated overexpression compared...