A5101964560- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Immunotherapy and Immune Responses
- Uterine Myomas and Treatments
- Endometriosis Research and Treatment
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Cancer-related molecular mechanisms research
- Pelvic floor disorders treatments
- Cervical Cancer and HPV Research
- Congenital gastrointestinal and neural anomalies
- Anorectal Disease Treatments and Outcomes
- Viral Infections and Immunology Research
- Urinary Bladder and Prostate Research
- Pediatric Urology and Nephrology Studies
- Hernia repair and management
- Lung Cancer Research Studies
- RNA modifications and cancer
- Intraperitoneal and Appendiceal Malignancies
- Immune cells in cancer
- Circular RNAs in diseases
- Viral gastroenteritis research and epidemiology
- Urological Disorders and Treatments
- Cancer, Stress, Anesthesia, and Immune Response
- Glioma Diagnosis and Treatment
National Taiwan University Hospital
2010-2025
Chang Gung University of Science and Technology
2021-2025
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2025
Wenzhou Medical University
2025
Chang Gung University
2016-2024
Soochow University
2024
Soochow University
2024
National Taiwan University
2014-2024
Suzhou Municipal Hospital
2024
Chengdu Third People's Hospital
2024
The nuclear receptors liver X receptor α (LXRα) (NR1H3) and LXRβ (NR1H2) are important regulators of genes involved in lipid metabolism, including <i>ABCA1</i>,<i>ABCG1</i>, sterol regulatory element-binding protein-1c (<i>SREBP-1c</i>). Although it has been demonstrated that oxysterols LXR ligands, little is known about the identity physiological activators these receptors. Here we confirm earlier studies demonstrating a dose-dependent induction ABCA1 ABCG1 human monocyte-derived...
Ovarian cancer has one of the highest mortalities in malignancies women, but little is known its tumour progression properties and there still no effective molecule that can monitor growth or therapeutic responses. MSLN (mesothelin), a secreted protein overexpressed ovarian tissues with poor clinical outcome, been previously identified to activate PI3K (phosphoinositide 3-kinase)/Akt signalling inhibit paclitaxel-induced apoptosis. The present study investigates correlation between MMP...
<h3>Background</h3> The standard treatment for epithelial ovarian carcinoma (EOC) is surgery followed by platinum/paclitaxel-based chemotherapy, but the overall survival rate poor. purpose of this study was to investigate therapeutic potential chemotherapy combined with inhibition B and T lymphocyte attenuator (BTLA) clinical use treat EOC. <h3>Methods</h3> Initially, we evaluated application anti-BTLA antibody in an animal model. We then analyzed distribution regulation BTLA expression on...
Although cancer vaccines are emerging as innovative methods for treatment, these alone have limited potential treating measurable tumor burden. Thus, the importance of identifying anticancer strategies with greater potency is necessary. The chimeric DNA vaccine CTGF/E7 (connective tissue growth factor linked to antigen human papillomavirus 16 E7) generates potent E7-specific immunity and antitumor effects. We tested immune-modulating doses chemotherapy in combination treat existing tumors...
Many autoimmune and infectious diseases are characterized by the formation of granulomas which inflammatory lesions that consist spatially organized immune cells. These sites protect host control pathogens like Mycobacterium tuberculosis (Mtb), but highly cause pathology. Using bacille Calmette-Guerin (BCG) Mtb infection in mice induce sarcoid or caseating granulomas, we show a subpopulation granuloma macrophages produces vascular endothelial growth factor (VEGF-A), recruits cells to...
While severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection presents with mild or no symptoms in most cases, a significant number of patients become critically ill. Remdesivir has been approved for the treatment disease 2019 (COVID-19) several countries, but its use as monotherapy not substantially lowered mortality rates. Because agents from traditional Chinese medicine (TCM) have successfully utilized to treat pandemic and endemic diseases, we designed current study...
Bile acids are known to play important roles as detergents in the absorption of hydrophobic nutrients and signaling molecules regulation metabolism. We tested novel hypothesis that naturally occurring bile interfere with protein-mediated hepatic long chain free fatty acid (LCFA) uptake. To this end, stable cell lines expressing transporters well primary hepatocytes from mouse human livers were incubated secondary determine their effects on LCFA uptake rates. identified ursodeoxycholic (UDCA)...
Obstructive sleep apnea (OSA) is associated with metabolic, endocrine, and cardiovascular diseases. It characterized by repetitive episodes of apnea/hypopnea hypoxia in tissues, which might also impact bone metabolism. This study investigates the possible association between OSA osteoporosis.Random samples 1 million individuals were collected from Taiwan's National Health Insurance database. A total 1377 patients newly diagnosed 2000 to 2008 recruited compared a matched cohort 20 655 without...
The immuno-inhibitory checkpoint PD-L1, regulated by tumor cells and antigen-presenting (APCs), dampened the activation of T from PD-1/PD-L1 axis. PD-L1-expressing APCs rather than demonstrated essential anti-tumor effects anti-PD-L1 monotherapy in preclinical models. Using murine model, we investigated whether antibody increased antigen-specific immune response induced protein vaccine, as well possible mechanisms regarding APCs. Anti-PD-L1 combined with PEK vaccine generated more potent...
Background: DC-STAMP domain containing 1-antisense 1 (DCST1-AS1) is a long noncoding RNA (lncRNA) that up-regulated in triple-negative breast cancer (TNBC) tissues. Here, we attempt to investigate the oncogenic property of DCST1-AS1. Methods: LncRNA microarrays were used detect differentially expressed lncRNA cancerous Fluorescence situ hybridization assay was distribution DCST1-AS1 BT-549 and MDA-MB-231 cells. Lentiviral systems, inhibitors, siRNA overexpression plasmids for gain-...
Triple-negative breast cancer (TNBC) is a highly metastatic subtype, and the primary systemic treatment strategy involves conventional chemotherapy. DC-STAMP domain containing 1-antisense 1 (DCST1-AS1) long non-coding RNA that promotes TNBC migration invasion. Studying role of DCST1-AS1 in promoting epithelial-mesenchymal transition (EMT) chemoresistance will provide new for therapy. In present study, we found regulates expression or secretion EMT-related proteins E-cadherin, snail family...
Enterovirus A71 (EV-A71), a positive-stranded RNA virus of the Picornaviridae family, may cause neurological complications or fatality in children. We examined specific factors responsible for this virulence using chemical genetics approach. Known compounds from an anti-EV-A71 herbal medicine, Salvia miltiorrhiza (Danshen), were screened anti-EV-A71. identified natural product, rosmarinic acid (RA), as potential inhibitor EV-A71 by cell-based antiviral assay and vivo mouse model. Results...
Colorectal cancer (CRC) is the fourth leading cause of cancer-related mortality globally. Therefore, a better understanding early molecular events this disease needed. Long noncoding RNAs (lncRNAs) play critical role in regulation tumorigenesis and progression. In study, we investigated characteristics ZFAS1 CRC. We analyzed three independent microarray datasets CRC tissues from GEO found that expression was remarkably upregulated all datasets. Moreover, validated overexpression compared...
Abstract Small cell lung cancer (SCLC), recognized as the most aggressive subtype of cancer, presents an extremely poor prognosis. Currently, patients with small face a significant dearth effective alternative treatment options once they experience recurrence and progression after first‐line therapy. Despite promising efficacy immunotherapy, particularly immune checkpoint inhibitors in non‐small (NSCLC) various other tumours, its impact on significantly enhancing prognosis SCLC remains...
ATP-binding cassette transporter A1 (ABCA1) mediates an active efflux of cholesterol and phospholipids is mutated in patients with Tangier disease. Expression ABCA1 may be increased by certain oxysterols such as 22(R)-hydroxycholesterol via activation the nuclear hormone receptor liver X (LXR). In searching for potential modulators expression, we have studied effects various mevalonate metabolites on expression two human cell lines, THP-1 Caco-2 cells. Most tested metabolites, including...
Uterine cancer was the most rapidly increasing malignancy and second common gynecologic in Taiwan.We analyzed secular trend of uterine incidence compare survival women with carcinomas sarcomas Taiwan. Data on diagnosed between 1979 2008 were obtained from Taiwan registry. Survival data by using Kaplan-Meier Cox proportional hazards regression methods.Records 11,558 1,226 analyzed. The age-adjusted rate endometrioid adenocarcinoma increased 0.83 per 100,000 year 1983 to 7.50 2004 2008. 5-year...
Rheumatoid arthritis (RA) is a chronic autoimmune disease that causes joint deformity and disability. Deer velvet antler (DA), traditional Chinese medicine, has been used to treat various types of for several thousands years, but the underlying mechanisms are unknown. Herein, we investigated anti-arthritic anti-inflammatory effects DA in vitro vivo. The ethyl acetate layer ethanol extract (DA-EE-EA) was tumor necrosis factor (TNF)-[Formula: see text]-stimulated fibroblast-like synoviocyte...
Lophatherum gracile (L. gracile) has long been used as a functional food and herbal medicine. Previous studies have demonstrated that extracts of L. attenuate inflammatory response inhibit SARS-CoV-2 replication; however, the underlying active constituents yet to be identified. This study investigated bioactive components gracile. Flavone C-glycosides were found dominate both anti-inflammatory antiviral effects. A simple chromatography-based method was developed obtain flavone...