A5102779155- Animal Nutrition and Physiology
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Adipose Tissue and Metabolism
- Meat and Animal Product Quality
- Adipokines, Inflammation, and Metabolic Diseases
- Circular RNAs in diseases
- Colorectal Cancer Surgical Treatments
- COVID-19 Clinical Research Studies
- Manufacturing Process and Optimization
- Vitamin D Research Studies
- Chemokine receptors and signaling
- Genetic factors in colorectal cancer
- Lipid metabolism and biosynthesis
- Genetic and phenotypic traits in livestock
- Cancer, Lipids, and Metabolism
- Gut microbiota and health
- Peroxisome Proliferator-Activated Receptors
- Biochemical effects in animals
- Cholangiocarcinoma and Gallbladder Cancer Studies
- HIV Research and Treatment
- Rabbits: Nutrition, Reproduction, Health
- Liver physiology and pathology
- RNA modifications and cancer
- Cytokine Signaling Pathways and Interactions
Southwest Minzu University
2022-2025
China Tobacco
2022-2024
Yunnan Vocational College of Mechanical and Electrical Technology
2024
Chengdu Women's and Children's Central Hospital
2023
University of Electronic Science and Technology of China
2023
Nanjing Medical University
2012-2023
Augusta University
2016-2023
Aviation General Hospital
2015-2023
Xichang University
2023
China Agricultural University
2019-2022
Intrinsic glomerular cells in a diabetic milieu have transcriptional activation of genes that influence the development nephropathy. The cellular repertoire microRNAs can regulate translation these expressed into proteins. Fibronectin is key matrix protein accumulated excess Here, we exposed cultured human and mouse mesangial to high glucose transforming growth factor-beta simulate milieu. In conditions vitro, as well nephropathy models vivo, microRNA-377 was consistently up-regulated...
The negative feedback mechanism is essential to maintain effective immunity and tissue homeostasis. 1,25-dihydroxyvitamin D (1,25[OH]2D3) modulates innate immune response, but the remains poorly understood. In this article, we report that vitamin receptor signaling attenuates TLR-mediated inflammation by enhancing inhibition. Vitamin inactivation leads hyperinflammatory response in mice macrophage cultures when challenged with LPS, because of microRNA-155 (miR-155) overproduction excessively...
Intake of n-3 polyunsaturated fatty acids (n-3 PUFAs) may protect against mild cognitive impairment (MCI). However, there is still a lack the PUFAs intervention in elderly with MCI China. The aim present study was to investigate effect PUFA supplementation on function Chinese MCI.Eighty six individuals aged 60 years or older were randomly assigned receive either (480 mg DHA and 720 EPA per day, n = 44) placebo (olive oil, 42) capsules. changes functions assessed using Basic Cognitive...
Vitamin D and its analogs have antiproteinuric activity podocytes express the vitamin receptor, but whether signaling in accounts for this renoprotection is unknown. To investigate question, we used 2.5 kb podocin promoter to target Flag-tagged human receptor (hVDR) DBA/2J mice. After induction of diabetes with streptozotocin, transgenic mice had less albuminuria than wild-type controls. In mice, a low dose analog doxercalciferol prevented albuminuria, markedly attenuated podocyte loss...
AIM:To investigate the effect of omega-3 fatty acid parenteral supplementation postoperatively on clinical outcomes and immunomodulation in colorectal cancer patients. METHODS:Forty-two patients undergoing radical resection with an indication for total nutrition were enrolled this prospective, double-blind, randomized, controlled study.Patients received supplemented either soybean oil (LCT; Intralipid ® , Fresenius-Kabi, SO group, n = 21) or a combination fish (LCT:fish 5:1, oil; Omegaven FO...
Although vitamin D has been implicated in cardiovascular protection, few studies have addressed the role of receptor (VDR) atherosclerosis. Here we investigate effect inactivation VDR signaling on atherogenesis and antiatherosclerotic mechanism D. Low density lipoprotein (LDLR)(-/-)/VDR(-/-) mice exhibited site-specific accelerated atherogenesis, accompanied by increases adhesion molecules proinflammatory cytokines aorta cholesterol influx macrophages. Macrophages showed marked renin...
The aim of the study was to evaluate oncological outcomes complete mesocolic excision (CME) in colon cancer patients.CME is considered a standard procedure for patients. However, previous evidence regarding effect CME on prognosis has fundamental limitations that prevent it from being fully accepted.Patients who underwent radical resection were enrolled between November 2012 and March 2016. According principles CME, patients stratified into 2 groups based intraoperative surgical fields...
Evidence is provided that the fibroproliferative actions of TGF-β are dependent on a metabolic adaptation sustains pathologic growth. Specifically, profibrotic signaling shown to require fatty acid synthase (FASN), an essential anabolic enzyme responsible for de novo synthesis acids. With use pharmacologic and genetic approaches, we show TGF-β-stimulated FASN expression independent Smad2/ 3 mediated via mammalian target rapamycin complex 1. In absence activity or protein, -driven fibrogenic...
TGF-β plays a central role in the pathogenesis of fibroproliferative disorders. Defining exact underlying molecular basis is therefore critical for development viable therapeutic strategies. Here, we show that expression facilitative glucose transporter 1 (GLUT1) induced by fibroblast lines and primary cells required profibrotic effects TGF-β. In addition, enhanced GLUT1 observed fibrotic areas lungs both patients with idiopathic pulmonary fibrosis mice are subjected to fibrosis-inducing...
Abstract Objective The atherogenic index of plasma (AIP), consisting triglycerides and high-density lipoprotein cholesterol, is applied to estimate the cardiovascular disease risk. evidence regarding association between AIP prehypertension or hypertension remains inconclusive. This study was conducted investigate in normoglycemic subjects Japan. Methods In present cross-sectional study, 15,453 participants aged 18 years older Gifu, Japan, were evaluated. selected separated into four groups...
Chemokine receptor CXCR4 plays an important role in the immune system and cellular entry of human immunodeficiency virus type 1 (HIV-1). To probe stereospecificity CXCR4-ligand interface, d-amino acid peptides derived from natural chemokines, viral macrophage inflammatory protein II (vMIP-II) stromal cell-derived factor-1α (SDF-1α), were synthesized found to compete with <sup>125</sup>I-SDF-1α monoclonal antibody 12G5 binding potency selectivity comparable or higher than their l-peptide...
// Xianxiu Ge 1, * , Youli Wang 2, Junjie Nie Quanpeng Li Lingyu Tang 1 Xueting Deng Fei Boming Xu Xiaochao Wu Xiuhua Zhang Qiang You 3 and Lin Miao Institute of Digestive Endoscopy Medical Center for Diseases, Second Affiliated Hospital Nanjing University, Nanjing, China 2 Department Clinical Laboratory, First Hospital, Biotherapy, These authors have contributed equally to this work Correspondence to: Miao, email: miaolinxh@163.com Keywords: cholangiocarcinoma, exosome, long non-coding...
Electrodeposition, which features low cost, easy scale-up, good control in the composition and great flexible substrate compatibility, is a favorable technique for producing thin films. This paper reviews use of electrodeposition fabrication several representative chalcogenides that have been widely used photovoltaic devices. The review focuses on narrating mechanisms formation films key factors affect morphology, composition, crystal structure electric properties ends with remark section...
The Lycium barbarum branches and leaves (LBL) are known to contain a range of active substances that have positive effects on animal immunity antioxidation. This study aimed examine how LBL impacts the growth slaughter performance as well rumen fermentation microbiota in Hu sheep. A total 50 male sheep indigenous origin, aged 3 months, were randomly divided into 5 groups 10 each. given different levels supplementation (0%, 3%, 6%, 9%, 12%) evaluate nutrient apparent digestibility. Rumen...
The entry of human immunodeficiency virus type 1 (HIV-1) into the cell is initiated by interaction viral surface envelope protein with two components target cell, CD4 and a chemokine coreceptor, usually CXCR4 or CCR5. natural ligand stromal cell-derived factor 1alpha (SDF-1alpha). Whereas overlap between HIV-1 SDF-1alpha functional sites on extracellular domains has been well documented, it yet to be determined whether there are in transmembrane (TM) helices important for and/or functions,...
Previous work identified an important role for hyperglycemia in diabetic nephropathy (The Diabetes Control and Complications Trial Research Group. N Engl J Med 329: 977-986, 1993; UK Prospective Study Lancet 352: 837-853, 1998), increased glomerular GLUT1 has been implicated. However, the roles of intracellular glucose have not determined. Here, we developed transgenic GLUT1-overexpressing mice (GT1S) to characterize development disease without diabetes. was overexpressed mesangial cells...
The goal of this study was to address the role ATP-citrate lyase (ACL), an enzyme that converts citrate acetyl-CoA, in high glucose (HG)-induced histone acetylation and profibrotic gene expression. Our recent ChIP-Seq studies have demonstrated HG induces genome-wide hyperacetylation mesangial cells (MCs). Here, we showed exposure MCs markedly increased at H3K9/14 H3K18 marks induced expression potent factors TGF-β1, TGF-β3, connective tissue growth factor (CTGF). induction these further...
Nephrin plays a key role in maintaining the structure of slit diaphragm glomerular filtration barrier. Our previous studies have demonstrated potent renoprotective activity for 1,25-dihydroxyvitamin D (1,25(OH)(2)D(3)). Here we showed that podocytes 1,25(OH)(2)D(3) markedly stimulated nephrin mRNA and protein expression. ChIP scan 6-kb 5' upstream region mouse gene identified several putative vitamin response elements (VDREs), EMSA confirmed VDRE at -312 (a DR4-type VDRE) could be bound by...
Objective: Both estrogen receptors, ER alpha (<TEX>$ER{\alpha}$</TEX>) and beta (<TEX>$ER{\beta}$</TEX>), are expressed in 50-70% of breast cancer cases. The role <TEX>$ER{\alpha}$</TEX> as a prognostic marker has been well established its expression is negative correlated with tumor size lymph node metastasis. <TEX>$ER{\beta}$</TEX> also favorable predictor although this less documented than for <TEX>$ER{\alpha}$</TEX>. Materials Methods: To explore whether ERs independently or together...
This study was designed to compare the effect of methionine (Met) sources (DL-methionine [DLM] and DL-2-hydroxy-4-methylthio-butanoic acid [HMTBa]) their supplementation levels on broiler growth performance redox state. A 2 × factorial arrangement used with (DLM HMTBa) (0.05% 0.25%) Met. total 480 one-day-old chicks were randomly divided into 4 treatments 8 replicates per treatment (15 birds replicate). The experiment lasted for 21 d. Broiler performance, capacity, redox-related genes...
Dietary supplemental with nicotinamide and butyrate sodium improve mitochondrial function, antioxidant capacity, gut microbiota.
Long noncoding RNAs (lncRNAs) have recently emerged as new regulatory molecules with diverse functions in regulating gene expression and significant roles the immune response. However, function of many unknown lncRNAs is still unclear. By studying effect daidzein (DA) on immunity, we identified a novel lncRNA an function: lncRNA- XLOC_098131. In vivo, DA treatment upregulated XLOC_098131, FOS JUN chickens affected activator protein 1 (AP-1) to regulate MAPK signaling, Toll-like receptor...