A5100324288- Receptor Mechanisms and Signaling
- Pancreatic function and diabetes
- Diabetes Treatment and Management
- Selenium in Biological Systems
- Trace Elements in Health
- Heavy Metal Exposure and Toxicity
- Hormonal Regulation and Hypertension
- Phytochemicals and Antioxidant Activities
- Genomics, phytochemicals, and oxidative stress
- Connective Tissue Growth Factor Research
- Nitric Oxide and Endothelin Effects
- Virology and Viral Diseases
- Intracranial Aneurysms: Treatment and Complications
- Liver Disease Diagnosis and Treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Neuropeptides and Animal Physiology
- Diet, Metabolism, and Disease
- Digestive system and related health
- Autophagy in Disease and Therapy
- Diabetes and associated disorders
- Wound Healing and Treatments
- Estrogen and related hormone effects
- Eicosanoids and Hypertension Pharmacology
- Pharmacological Effects of Natural Compounds
- Herpesvirus Infections and Treatments
Kunming Medical University
2020-2025
Henan Institute of Science and Technology
2024-2025
National Institute of Diabetes and Digestive and Kidney Diseases
2021-2025
Zhejiang Chinese Medical University
2024
National Institutes of Health
2009-2024
Chongqing University
2024
Guizhou Provincial People's Hospital
2024
Huazhong University of Science and Technology
2009-2023
Tongji Hospital
2009-2023
Jinan University
2018-2022
Abstract A GGGGCC hexanucleotide repeat expansion in intron 1 of chromosome 9 open reading frame 72 ( C9ORF72 ) gene is the most common genetic cause amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. Repeat-associated non-ATG translation dipeptide proteins (DPRs) contributes to neuropathological features c9FTD/ALS. Among five DPRs, arginine-rich poly-PR are reported be toxic. Here, we generate a transgenic mouse line that expresses (GFP-PR 28 specifically neurons. GFP-PR...
The cytochrome P450 epoxygenase, CYP2J2, converts arachidonic acid to four regioisomeric epoxyeicosatrienoic acids (EETs). We found recently that this enzyme is dramatically up-regulated in a variety of established human carcinoma cell lines and cancerous tissue promotes the neoplastic phenotype. In present study, we tested hypothesis specific inhibitors CYP2J2 related drug terfenadine are effective antitumor agents. Four these (compounds 4, 5, 11, 26) were for effectiveness vitro vivo....
Epoxyeicosatrienoic acids (EETs) and the cytochrome P450 epoxygenase CYP2J2 promote tumorogenesis in vivo vitro via direct stimulation of tumor cell growth inhibition apoptosis. Herein, we describe a novel mechanism apoptosis by EETs. In Tca-8113 cancer cells, antileukemia drug arsenic trioxide (ATO) led to generation reactive oxygen species (ROS), impaired mitochondrial function, induced 11,12-EET pretreatment increased expression antioxidant enzymes superoxide dismutase catalase inhibited...
Infectious bursal disease (IBD) significantly affects the poultry industry, causing substantial economic losses. This study aimed to investigate effects of ghrelin on chicks infected with an attenuated virus strain IBDV (aIBDV). Chicks were divided into three groups: a control group (Group I), aIBDV infection II), and + III). Mice in groups II III fed until they reached 19 days age then inoculated establish subclinical model. Group received intraperitoneal injection 0.5 nmol/100 g from 17...
Tumor necrosis factor (TNF)-α is a well-known pro-inflammatory cytokine. Increased expression of Tnf-α feature inflammatory lung diseases, such as asthma, emphysema, fibrosis and smoking-induced chronic obstructive pulmonary disease (COPD). Using mouse line with lung-specific overexpression (SPC-TNF-α) to mimic TNF-α-associated we investigated the role inflammation in homeostasis trace elements. We performed quantitative survey micronutrients biometals, including copper (Cu), zinc (Zn)...
Zrt/Irt-like protein 8 (ZIP8) (encoded by Slc39a8) is a multifunctional membrane transporter that influxes essential metal cations Zn
Glucagon, a hormone released from pancreatic α cells, plays key role in maintaining euglycemia. New insights into the signaling pathways that control glucagon secretion may stimulate development of novel therapeutic agents. In this study, we investigated potential regulation cell function by G proteins Gq family. The use chemogenetic strategy allowed us to selectively activate mouse cells vitro and vivo. Acute stimulation led elevated plasma levels, accompanied increased insulin release...
Abstract Glucagon, a hormone released from pancreatic α-cells, is critical for maintaining euglycemia and plays key role in the pathophysiology of diabetes. To stimulate development new classes therapeutic agents targeting glucagon release, α-cell signaling pathways that regulate secretion need to be identified. Here, we focused on potential importance G s modulating function. Studies with α-cell-specific mouse models showed activation causes marked increase secretion. We also found...
Background: Nephrotoxicity of drugs contributes to acute kidney injury with high mortality and morbidity, which crucially limits the application development drugs. Although many publications on nephrotoxicity have been conducted globally, there needs be a scientometric study systematically analyze intellectual landscape frontiers research trends in future. Methods: Publications from 2011 2021 were collected perform bibliometric visualization using VOSviewer, CiteSpace, Scimago Graphica...
Purpose: To employ response surface methodology (RSM) hinged on a central composite design (CCD) for the optimization of extraction polyphenols from Sorghum moench (Sorghum M).Methods: The combined influence independent variables were assessed with RSM. Total phenolic content (TPC) determination was carried out using Folin-Ciocalteu method. Derivative compounds acid assayed high performance liquid (HPLC). Antioxidant potential determined through 1,1-diphenyl-2- picrylhydrazyl (DPPH) radical...
Many individuals infected with human immunodeficiency virus (HIV) are also afflicted HIV-associated neurocognitive disorders (HANDs). Methamphetamine (METH) abuse puts HIV-1 patients at risk for HANDs because METH and proteins, such as trans-activator of transcription (Tat), can synergistically damage the blood-brain barrier (BBB). However, underlying mechanism METH- HIV-Tat-induced BBB remains unclear. In this study, male adult tree shrews brain capillary endothelial cells were treated...
Following a meal, glucagon-like peptide-1 (GLP1) and glucose-dependent insulinotropic polypeptide (GIP), the two major incretins promoting insulin release, are secreted from specialized enteroendocrine cells (L- K-cells, respectively). Although GIP is dominant incretin in humans, detailed molecular mechanisms governing its release remain to be explored. secretion regulated by activity of G protein-coupled receptors (GPCRs) expressed K-cells. GPCRs couple one or more specific classes...