A5022304011- Radiation Detection and Scintillator Technologies
- Nuclear Physics and Applications
- Dementia and Cognitive Impairment Research
- Particle Detector Development and Performance
- Dark Matter and Cosmic Phenomena
- Advanced X-ray and CT Imaging
- Atomic and Subatomic Physics Research
- Advanced Semiconductor Detectors and Materials
- Particle physics theoretical and experimental studies
- Cardiac Ischemia and Reperfusion
- Neurological Disease Mechanisms and Treatments
- Health disparities and outcomes
- Cerebrovascular and Carotid Artery Diseases
- Health, Environment, Cognitive Aging
- Dental Implant Techniques and Outcomes
- Physical Activity and Health
- Mycorrhizal Fungi and Plant Interactions
- Medical Imaging Techniques and Applications
- Bone Tissue Engineering Materials
- Cerebrospinal fluid and hydrocephalus
- Fungal Biology and Applications
- Cardiovascular Function and Risk Factors
- Cardiac Arrest and Resuscitation
- Electronic and Structural Properties of Oxides
- Advanced Neuroimaging Techniques and Applications
Hebei Normal University
2023-2025
Stockholm University
2021-2025
Karolinska Institutet
2020-2025
Swedish School of Sport and Health Sciences
2024-2025
Chongqing Medical University
2012-2025
The Affiliated Yongchuan Hospital of Chongqing Medical University
2012-2025
Guang’anmen Hospital
2025
China Academy of Chinese Medical Sciences
2025
Tsinghua University
2014-2024
Renmin Hospital of Wuhan University
2024
Background Cognitive reserve (CR), typically measured through socio-behavioral proxies, can partially explain better cognitive performance despite underlying brain aging or neuropathology. Objective To examine the associations of CR with mild impairment (MCI) and function while considering Alzheimer's disease (AD)-related plasma biomarkers. Methods This population-based cross-sectional study included 4706 dementia-free individuals from MIND-China. Data on AD-related biomarkers were available...
A high-fat diet (HFD) is associated with adipose inflammation, which contributes to key components of metabolic syndrome, including obesity and insulin resistance. The increased visceral tissue mass the result hyperplasia hypertrophy adipocytes. To investigate effects exercise on HFD-induced disorders, male C57BL/6 mice were divided into four groups: SED (sedentary)-ND (normal diet), EX (exercise)-ND, SED-HFD, EX-HFD. Exercise was performed a motorized treadmill at 15 m/min, 40 min/day, 5...
China JinPing underground Laboratory (CJPL) is the deepest laboratory presently running in world. In such a deep laboratory, cosmic ray flux very important and necessary parameter for rare event experiments. A plastic scintillator telescope system has been set up to measure flux. The performance of studied using on ground near CJPL. Based experimental data taken from November 2010 December 2011 CJPL, which effective live time 171 days, muon CJPL measured be (2.0+-0.4)*10^(-10)/(cm^2)/(s)....
The China Jinping Underground Laboratory, inaugurated in 2010, is an underground research facility with the deepest rock overburden and largest space by volume world. first-generation science programs include dark matter searches conducted CDEX PandaX experiments. These activities are complemented measurements of ambient radioactivity installation low-background counting systems. Phase II being constructed, its potential projects formulated. In this review, we discuss history, key features,...
Olfactory impairment is a potential marker for prodromal dementia, but the underlying mechanisms are poorly understood. This population-based study included 4214 dementia-free participants (age ≥65 years). Olfaction was assessed using 16-item Sniffin' Sticks identification test. In subsamples, we measured plasma amyloid beta (Aβ)40, Aβ42, total tau, and neurofilament light chain (NfL; n = 1054); quantified hippocampal, entorhinal cortex, white matter hyperintensity (WMH) volumes, Alzheimer's...
Epoxyeicosatrienoic acids (EETs) and the cytochrome P450 epoxygenase CYP2J2 promote tumorogenesis in vivo vitro via direct stimulation of tumor cell growth inhibition apoptosis. Herein, we describe a novel mechanism apoptosis by EETs. In Tca-8113 cancer cells, antileukemia drug arsenic trioxide (ATO) led to generation reactive oxygen species (ROS), impaired mitochondrial function, induced 11,12-EET pretreatment increased expression antioxidant enzymes superoxide dismutase catalase inhibited...
Drug delivery and release are a major challenge fabricating bone tissue engineering. In this study, we fabricated new sustained hydrogel scaffolds composited of mesoporous bioactive glass, sodium alginate gelatin by three-dimensional printing technique. Naringin calcitonin gene-related peptide were used as drugs to prepare drug-loaded direct or surface absorption. The physicochemical properties the drug profiles two drug-loading models investigated. We also examined biocompatibility...
The quality attributes of jujube fruit can be directly and indirectly affected by abiotic stresses associated with climate change. Increased temperature drought are among the most important factors challenging sustainable production in temperate semi-arid region northwest China. main objective present study was to understand effects elevated air stress on sugar acid accumulation coloration fruits. content soluble sugar, organic pigments traditional "Linwuchangzao" under different atmospheric...
An energy conversion efficiency of 35% was obtained at 1-sun, air mass 1.5 for a novel silicon cell. The critical feature the cell structure is inclusion local defect layers near p-n junction. were proven to hold key achieving exceptionally high fabricated via noncomplex processing.
Degenerative cartilage endplate (CEP) shows decreased chondrification and increased ossification. Cartilage stem cells (CESCs), with the capacity for chondro-osteogenic differentiation, are responsible CEP restoration. is avascular hypoxic, while physiological hypoxia disrupted in degenerated CEP. Hypoxia promoted chondrogenesis but inhibited osteogenesis CESCs. This tissue-specific differentiation fate of CESCs response to was physiologically significant regard maintaining refusing MIF, a...
Abstract Background Cardiovascular health (CVH) metrics among Chinese older adults are poorly understood. We investigated sex disparities in CVH and their management rural-dwelling China. Methods This community-based study included 5026 participants (age ≥ 65 years; 57.2% women) the baseline survey of a multimodal intervention rural In March–September 2018, data were collected through face-to-face interviews, clinical examinations, laboratory tests. defined six (three behavioral...
Abstract INTRODUCTION To examine the burden and clusters of multimorbidity in association with mild cognitive impairment (MCI), dementia, Alzheimer's disease (AD)‐related plasma biomarkers among older adults. METHODS This population‐based study included 5432 participants (age ≥60 years); these, amyloid beta (Aβ), total tau, neurofilament light chain (NfL) were measured a subsample ( n = 1412). We used hierarchical clustering to generate five from 23 chronic diseases. diagnosed dementia MCI...
This study focuses on developing a self-triggered data acquisition system and noise reduction algorithm for the Multi-gap Resistive Plate Chamber (MRPC) Time-of-Flight Positron Emission Tomography (TOF-PET) system. The integrates fast front-end amplifier, waveform digitization module based DRS4 chip, an efficient to address challenges such as high trigger rates precise gamma-ray detection. proposed system, through threshold discrimination, coincidence logic, continuous oscillation check,...
Emodin alleviates renal interstitial fibrosis (RIF) and reduces inflammation by inhibiting the TGF-β1/Smad pathway, thus improving CKD outcomes. However, its clinical use is limited due to poor solubility side effects. This study developed a targeted drug delivery system using αKIM-1 modified microbubbles carrying enhance accumulation in tissues with high KIM-1 expression. Emo@KP MBs were characterized TEM DLS, their loading encapsulation rates measured UV-VIS-NIR spectroscopy....
Background The mechanisms underlying olfactory decline in aging need further investigation. Noticeably, the longitudinal relationship of biological markers with olfaction remains underexplored. We investigated whether baseline levels and progression microvascular lesions brain atrophy are associated odor identification (OID) decline. Methods association between structural MRI OID was examined participants from SNAC-K study who were free dementia at ( n = 401, mean age 70.2 years, 60%...