A5101678158- Dementia and Cognitive Impairment Research
- Pharmacological Effects and Toxicity Studies
- Neuroscience and Neuropharmacology Research
- Acute Lymphoblastic Leukemia research
- Cholesterol and Lipid Metabolism
- Epilepsy research and treatment
- Drug-Induced Hepatotoxicity and Protection
- Lung Cancer Research Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Biochemical Analysis and Sensing Techniques
- Advanced Chemical Sensor Technologies
- Cancer, Lipids, and Metabolism
- Lipid metabolism and biosynthesis
- RNA modifications and cancer
- Respiratory viral infections research
- Nutritional Studies and Diet
- Olfactory and Sensory Function Studies
- Cancer Research and Treatments
- Migraine and Headache Studies
- Immune cells in cancer
- Bipolar Disorder and Treatment
- Health Literacy and Information Accessibility
- Muscle activation and electromyography studies
- Chronic Myeloid Leukemia Treatments
- Patient Safety and Medication Errors
Shandong Provincial Hospital
2020-2025
Shandong First Medical University
2020-2025
Shandong University
2020-2025
Chongqing Medical University
2008-2025
Children's Hospital of Chongqing Medical University
2016-2025
Shanghai University of Sport
2024
Fujian Provincial Cancer Hospital
2023
Fujian Medical University
2023
China International Science and Technology Cooperation
2017-2021
Xi'an Jiaotong University
2018
Olfactory impairment is a potential marker for prodromal dementia, but the underlying mechanisms are poorly understood. This population-based study included 4214 dementia-free participants (age ≥65 years). Olfaction was assessed using 16-item Sniffin' Sticks identification test. In subsamples, we measured plasma amyloid beta (Aβ)40, Aβ42, total tau, and neurofilament light chain (NfL; n = 1054); quantified hippocampal, entorhinal cortex, white matter hyperintensity (WMH) volumes, Alzheimer's...
Background Cognitive reserve (CR), typically measured through socio-behavioral proxies, can partially explain better cognitive performance despite underlying brain aging or neuropathology. Objective To examine the associations of CR with mild impairment (MCI) and function while considering Alzheimer's disease (AD)-related plasma biomarkers. Methods This population-based cross-sectional study included 4706 dementia-free individuals from MIND-China. Data on AD-related biomarkers were available...
We sought to develop a practical tool for predicting dementia risk among rural-dwelling Chinese older adults. This cohort study included 2220 rural adults (age ≥ 65 years) who were dementia-free at baseline (2014) and followed in 2018. Dementia was diagnosed following the DSM-IV criteria. The prediction model constructed using Cox models. used C-index calibration plots assess performance, decision curve analysis (DCA) clinical usefulness. During 4-year follow-up, 134 individuals with...
Acyl-CoA:cholesterol acyltransferase (ACAT) plays important roles in cellular cholesterol homeostasis. Four human ACAT-1 mRNAs (7.0, 4.3, 3.6, and 2.8 kilobases (kb)) share the same short 5′-untranslated region (exon 1) coding sequence (exons 2–15). The 4.3-kb mRNA contains an additional (1289 nucleotides length; exons Xa Xb) immediately upstream from exon 1 sequence. One genomic DNA insert covers 1–16 a promoter (the P1 promoter). A separate (1277 base pairs) different P7 Gene mapping shows...
Human acyl-coenzyme A:cholesterol acyltransferase 1 (hACAT1) esterifies cholesterol at the endoplasmic reticulum (ER). We had previously reported that hACAT1 contains seven transmembrane domains (TMD) (Lin, S., Cheng, D., Liu, M. Chen, J., and Chang, T. Y. (1999) J. Biol. Chem. 274, 23276-23285) nine cysteines. The Cys near N-terminal is located cytoplasm; two cysteines C-terminal form a disulfide bond are in ER lumen. other six free buried region(s) of enzyme (Guo, Z.-Y., C. Y., Lu, X., Li,...
•Patients with dmNPC receiving chemotherapy plus anti-PD-1 mAbs had an ORR of 92.0% and a median PFS 20 months.•Chemotherapy monoclonal antibodies followed by LRRT improves survival outcomes.•Early clearance EBV DNA is biomarker for identifying suitable candidates in the era immunotherapy. BackgroundWe aimed to investigate efficacy locoregional radiotherapy (LRRT) patients de novo metastatic nasopharyngeal carcinoma (dmNPC) combined anti-programmed cell death receptor-1 (anti-PD-1 mAbs) as...
Background: Medication safety is crucial in clinical care. Although many hospitals have implemented prospective prescription review systems to manage medication use, the impact of these on pediatric patients not yet fully understood. Objectives: We explore characteristics and economic impacts identify factors influencing intervention success rates. Design: This study adopted a cross-sectional design. Methods: Prospective tasks were compared outpatient our hospital between 2021 2023 assess...
Aims Soluble guanylyl cyclase (sGC) is a key modulator in the regulation of vascular tone. However, its role and involving mechanism cholesterol metabolism macrophages atherosclerosis remain unclear. Methods Oil red O staining, Dil-oxidized low-density lipoprotein (oxLDL)-binding assay efflux were performed biology foam cells. Levels cytokines or intracellular lipid evaluated by ELISA colorimetric kits. Expression gene protein was determined quantitative real-time PCR Western blotting....
Augmented renal clearance (ARC) can cause underexposure to vancomycin, thereby increasing the risk of treatment failure. Our objective was evaluate population pharmacokinetics and optimize dosing regimen vancomycin in a pediatric with ARC. Sparse pharmacokinetic sampling therapeutic drug monitoring (TDM) data were collected from patients ARC treated vancomycin. A model developed using NONMEM 7.2. The optimized Monte Carlo dose simulations. total 242 serum concentrations 113 (age range, 0.4...
The carbon nanotubes (CNT)/polyimide (PI) composites were prepared by blending and characterized Fourier transform infrared spectrometer (FTIR), thermogravimetric analysis (TGA), transmission electron microscopy (TEM) N<sub>2</sub>adsorption–desorption.
Little is known about the associations of hearing loss, hippocampal volume, and motoric cognitive risk syndrome (MCR) in older adults.
BACKGROUND:Since the epidemiological profile of drug-induced liver injury (DILI) in China, especially western it has rarely been studied. The aim this study was to analyze characteristics DILI patients a large tertiary teaching hospital at Chongqing, municipality China. MATERIAL AND METHODS:The medical records hospitalized which diagnosed with between January 2011 and December 2016 were searched retrospectively, demographic, clinical data, laboratory data retrieved for analysis. RESULTS:A...
Specific fusion genes play important roles as risk factors for strategic treatment in pediatric B-cell acute lymphoblastic leukemia (B-ALL), and the patients without common have not been well demonstrated. We collected analyzed clinical laboratory findings, responses outcomes B-ALL specific genes. Whole-exome sequencing (WES) and/or RNA (RNAseq) data from bone marrow relapsed were also analyzed. 283 enrolled study. Traditional elements at different time points (TPs) evaluated to classify...
This study aims to examine the features of online pediatric pharmacy consultations in Southwest China, an area with limited medical resources during post-epidemic era and explore factors affecting dialogue volume consultations. A cross-sectional was conducted southwest China from April 2022 March 2023. The encompassed a cohort 2,526 children, ranging 0 18 years old. collected data patient gender, age, weight, department, drugs involved consultation services, types questions consulted, start...
Cervical intraepithelial neoplasia (CIN) is an important precursor of cervical cancer. Early detection and treatment can reduce the incidence
This study investigated muscle activation, shocks, and vibrations of the upper extremities during tennis serves between junior adult players. Thirty-five well-trained players (15 juniors 20 adults) performed 10 maximal successful serves. Two triaxial accelerometers recorded shock vibration on racket hand dominant side. Eight surface EMG electrodes were also used to measure arm muscles’ activities. Linear mixed models test fixed effect age muscular activation vibration. Statistical...
Although discontinuation is common in clinical trials, no study has been conducted to analyse the current situation and reasons for suspension or of drug trials China. This aims general characteristics registered mainland China identify associated factors.We a cross-sectional observational discontinued Drug Trial Registration Information Publication Platform before March 31, 2020. All with status terminated stopped recorded platform were classified as included analysis. The basic recorded,...