A5052395114- Retinal Diseases and Treatments
- Intraocular Surgery and Lenses
- Glaucoma and retinal disorders
- Retinal Development and Disorders
- Retinal Imaging and Analysis
- Traumatic Ocular and Foreign Body Injuries
- Retinal and Optic Conditions
- Retinal and Macular Surgery
- Corneal surgery and disorders
- Amino Acid Enzymes and Metabolism
- Ophthalmology and Visual Impairment Studies
- Connexins and lens biology
- Angiogenesis and VEGF in Cancer
- Pharmacogenetics and Drug Metabolism
- Machine Learning in Healthcare
- MicroRNA in disease regulation
- Ocular Surface and Contact Lens
- Artificial Intelligence in Healthcare and Education
- Lung Cancer Treatments and Mutations
- Pancreatic function and diabetes
- Epigenetics and DNA Methylation
- Healthcare and Venom Research
- Ocular Oncology and Treatments
- SARS-CoV-2 and COVID-19 Research
- Corneal Surgery and Treatments
Shandong Provincial QianFoShan Hospital
2021-2025
Shandong First Medical University
2020-2025
Second Affiliated Hospital of Zhejiang University
2015-2024
Northeastern University
2023-2024
Zero to Three
2023
Zhejiang University
2010-2022
Guangdong Provincial People's Hospital
2022
Eye Center
2014-2021
He Eye Hospital
2021
China Pharmaceutical University
2020
Objective: miR-126, the miRNA considered to be specially expressed in endothelial cells and hematopoietic progenitor cells, is strongly associated with angiogenesis.The purpose evaluate role of miR-126 hypoxia-induced angiogenesis possible mechanisms.Methods: The expression was detected hypoxia-treated RF/6A diabetic retinas using real-time PCR.The up-or down-regulated by transfecting miR-126-mimics or inhibitors into cells.Cell cycle analysis performed flow cytometry.The protein levels...
Benefiting from rich knowledge and the exceptional ability to understand text, large language models like ChatGPT have shown great potential in English clinical environments. However, performance of non-English settings, as well its reasoning, not been explored depth.
ABSTRACT PURPOSE: To compare the astigmatism, high order aberrations, and optical quality of cornea after microincision (~1.7 mm) versus small incision (~3.2 cataract surgery at Eye Center, Zhejiang University, Hangzhou, China. METHODS: This prospective, randomized clinical study included performed on 60 eyes. Corneal astigmatism higher aberrations to sixth were measured using NIDEK OPD-Scan aberrometer/topographer 1 month surgery. evaluate cornea, 0.5 modulation transfer function (MTF)...
Diabetic retinopathy (DR) has been reported to associate with gut microbiota alterations in murine models and thus “gut-retina-axis” proposed. However, the role of microbiome associated metabolism DR patients still need be elucidated. In this study, we collected fecal samples from 45 proliferative diabetic (PDR) 90 matched (1:2 according age, sex, duration diabetes) without (NDR) performed 16S rRNA gene sequencing untargeted metabolomics. We observed significantly lower bacterial diversity...
Safe and efficacious antiviral therapeutics are in urgent need for the treatment of coronavirus disease 2019. Simnotrelvir is a selective 3C-like protease inhibitor that can effectively inhibit severe acute respiratory syndrome 2 (SARS-CoV-2). We evaluated safety, tolerability, pharmacokinetics dose escalations simnotrelvir alone or with ritonavir (simnotrelvir simnotrelvir/ritonavir) healthy subjects, as well food effect (ClinicalTrials.gov Identifier: NCT05339646). The overall incidence...
Two novel cyclodepsipeptides containing an unusual anthranilic acid dimer and a D-phenyllactic residues, clavatustides A B, were identified from cultured mycelia broth of Aspergillus clavatus C2WU isolated Xenograpsus testudinatus, which lives at extreme, toxic habitat around the sulphur-rich hydrothermal vents in Taiwan Kueishantao. This is first example cyclopeptides natural products, report microbial secondary metabolites vent crab. Clavatustides B suppressed proliferation hepatocellular...
To examine the safety of outpatient clinic simultaneous intravenous fundus fluorescein angiography (IVFA) and indocyanine green (ICGA) in patients with any/all drug allergy history.In a single-center retrospective study conducted from February 2007 to March 2011, 390 consecutive outpatients history 3426 without underwent IVFA ICGA. The detailed history, symptoms time adverse reaction during ICGA were recorded all patients.Of who received ICGA, 28 (7.2%) had an reaction. In contrast, 145...
Different clinical presentations and prognoses have been implied between pancreatic head body/tail cancers. We aimed to identify the prognostic relevance of primary tumor location in patients undergoing resection for ductal adenocarcinoma (PDAC). Thirty-two pairs with strictly matched early stage (II) cancers were enrolled. The molecular feature two subtypes PDAC was assessed on level miRNA expression. Out 64 patients, 34 (53.1%) had recurrence after radical during follow-up period (2.3 ±...
Augmented renal clearance (ARC) can cause underexposure to vancomycin, thereby increasing the risk of treatment failure. Our objective was evaluate population pharmacokinetics and optimize dosing regimen vancomycin in a pediatric with ARC. Sparse pharmacokinetic sampling therapeutic drug monitoring (TDM) data were collected from patients ARC treated vancomycin. A model developed using NONMEM 7.2. The optimized Monte Carlo dose simulations. total 242 serum concentrations 113 (age range, 0.4...
To investigate the clinical features and cytochrome P450 family 4 subfamily V polypeptide 2 (CYP4V2) gene mutations in 14 Chinese families with Bietti crystalline dystrophy (BCD).Seventeen patients from unrelated BCD were recruited for complete ophthalmic examination genetic study. The 11 exons of CYP4V2 amplified genomic DNA all their members by polymerase chain reaction (PCR) then sequenced. Exons TIMP3 also sequenced patient associated choroidal neovascularization (CNV). One hundred...
Choroidal neovascularization (CNV) is a major cause of vision loss in many retinal diseases. Hypoxia determined to be key inducer CNV and hypoxia-inducible factor-1 (HIF-1) an important transcription factor. Epithelial-mesenchymal transition (EMT) the synthesis proangiogenic cytokines make great contributions development CNV. In present study, role HIF-1α signaling regulation angiogenin (ANG) expression EMT hypoxic pigment epithelial cells was investigated. A significant elevation ANG level...
A naturally new cyclopeptide, clavatustide C, was produced as a stress metabolite in response to abiotic elicitation by one of the hydrothermal vent fluid components Zn cultured mycelia Aspergillus clavatus C2WU, which were isolated from Xenograpsus testudinatus. X. testudinatus lives at extreme, toxic habitat around sulphur-rich vents Taiwan Kueishantao. The known compound B also and purified. This is first example microbial secondary treatment. structures established spectroscopic means....
Abstract Idiopathic choroidal neovascularization (ICNV) is a disorder that primarily affecting patients younger than 50 years and can cause severe loss of vision. Choroidal abnormalities, especially inflammation, have been thought to be involved in the pathophysiology ICNV. However, exact pathogenesis ICNV remains unclear. The aim our study was investigate levels 27 inflammatory cytokines aqueous humor eyes with determine effect intravitreal injection ranibizumab (IVR) on cytokine levels....
In recent years, the discovery of clinical pathways (CPs) from electronic medical records (EMRs) data has received increasing attention because it can directly support doctors with explicit treatment knowledge, which is one key challenges in development intelligent healthcare services. However, existing work focused on topic probabilistic models, usually produce patterns similar activities, and such discovered do not take into account temporal process patient does meet needs practical applications.
Oxidative stress plays a significant role in the progression of cataract. We aimed to investigate protective effect magnolol, compound extracted from Chinese herb Magnolia officinalis, against oxidative human lens epithelial (HLE) cells as well possible molecular mechanism involved. In this study, magnolol was observed protect H 2 O -induced cytotoxicity HLE B-3 cells. Magnolol inhibited generation reactive oxygen species (ROS), loss mitochondrial membrane potential (Δ ψ m) and release...
Purpose: To establish quantitative profile of the morphologic changes among patients with active myopic choroidal neovascularization (mCNV) before and after anti-vascular endothelial growth factor (VEGF) therapy using optical coherence tomography angiography (OCTA) to assess therapeutic response. Methods: Patients mCNV who received anti-VEGF injections between February 2017 October 2020 fit study criteria were retrospectively reviewed. Quantitative analysis their OCTA images carried out...
To evaluate the visual function after bilateral implantation of aspheric diffractive multifocal Tecnis ZMA00, monofocal ZA9003 versus spherical Akreos Adapt intraocular lenses (IOLs).Tecnis or IOLs were bilaterally implanted in 180 eyes from 90 patients. The following parameters assessed 3 months postoperatively: monocular and binocular uncorrected acuity (UCVA) distance-corrected (DCVA) for distance, intermediate near, aberration (SA), contrast glare sensitivity, near point refractive...
Purpose: Deficiency of adenosine deaminase 2 (DADA2) is a rare autosomal recessive systemic autoinflammatory disorder. We describe case an adult patient with DADA2 who presented unilateral frosted branch angiitis (FBA) combined retinal vein occlusion and panuveitis. Method: This paper clinical report. Results: A 31-year-old male complained blurred vision in his right eye for days. His fundus examination showed FBA He had medical history intermittent recurrent fever, skin rash aphthous ulcer...