A5090280140- Natural product bioactivities and synthesis
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Phytochemistry and Biological Activities
- Traditional and Medicinal Uses of Annonaceae
- Phytochemical compounds biological activities
- Chemical synthesis and alkaloids
- Microbial Natural Products and Biosynthesis
- Bioactive Natural Diterpenoids Research
- Biological Activity of Diterpenoids and Biflavonoids
- Pharmacological Effects of Natural Compounds
- Marine Sponges and Natural Products
- Crystallography and molecular interactions
- Plant biochemistry and biosynthesis
- Advanced Synthetic Organic Chemistry
- Bioactive natural compounds
- Synthetic Organic Chemistry Methods
- Traditional Chinese Medicine Analysis
- Phytochemistry and Bioactivity Studies
- Phytochemistry and Bioactive Compounds
- Alkaloids: synthesis and pharmacology
- Essential Oils and Antimicrobial Activity
- Sesquiterpenes and Asteraceae Studies
- Phytochemicals and Antioxidant Activities
- Biological Stains and Phytochemicals
Zhejiang Chinese Medical University
2024-2025
Zhejiang University
2016-2025
Zhejiang Pharmaceutical College
2025
Wuyi University
2021-2024
Wuyi University
2020-2024
Zhejiang Modern Chinese Medicine and Natural Medicine Research Institute (China)
2012-2021
Hangzhou Xixi hospital
2015-2019
State Council of the People's Republic of China
2016-2019
Hangzhou Academy of Agricultural Sciences
2015-2019
Shanghai Institute of Materia Medica
2005-2016
Seventeen new alkaloids (1-17) and 14 known analogues have been isolated from an aqueous extract of the root Isatis indigotica. The structures absolute configurations these compounds were determined by extensive spectroscopic data analysis, including 2D NMR, single-crystal X-ray crystallography using anomalous scattering Cu Kα radiation, electronic circular dichroism spectra calculations based on quantum-mechanical time-dependent density functional theory. Compounds 1, 2, 3 are first...
Ten new fungal metabolites, including three hydroisocoumarins, penicimarins A–C (1–3), isocoumarins, D–F (6–8), and four benzofurans, penicifurans A–D (11–14), together with known isocoumarin derivatives (4, 5, 9, 10), were obtained from the sponge-derived fungus Penicillium sp. MWZ14-4, collected South China Sea. Their planar structures relative configurations elucidated by detailed analysis of spectroscopic data comparison related compounds. The absolute 1–4 assigned modified Mosher's...
Stimuli-responsive unimolecular chirality switching is a highly intriguing topic because the molecular structure as well its function can be adjusted simultaneously by process. Herein, novel acid/base-tunable system based on pillar[5]azacrown pseudo[1]catenane reported. The bicyclic PN4 synthesized through fusing an azacrown ring onto one repeating unit of pillar[5]arene. Protonation and deprotonation reversibly regulate conformational transformations between self-inclusion self-exclusion...
Pericarpium Citri Reticulatae 'Chachiensis' (PCRC), the premium aged pericarps of Reticulatae, is widely used in traditional Chinese medicines with a diversity promising bioactivity. Herein we report extraction, characterization and underlying mechanism anti-metabolic syndrome an arabinan-rich polysaccharide from PCRC (PCRCP). This was obtained 7.0% yield by using ultrasound-assisted extraction under optimized conditions 30 mL/g liquid-to-solid ratio, 250 W ultrasound power for 20 min at 90...
With the escalating prevalence of global heat waves, stroke has become a prominent health concern, leading to substantial liver damage. Unlike other forms injury, stroke-induced damage is characterized by cytotoxicity and heightened inflammation, directly contributing elevated mortality rates. While clinical assessments have identified bilirubin levels as indicative Kupffer cell dysfunction, their specific correlation with injury remains unclear. Our hypothesis proposes involvement...
A new enantiomeric pair of spirodiketones, (+)- and (−)-denobilone (1 2), three phenanthrene derivatives (3–5), biphenanthrenes (22–24), along with 11 known (6–16), five bibenzyl (17–21), four (25–28), were isolated from Dendrobium nobile. The structures 1–5 22–24 elucidated using comprehensive spectroscopic methods. (+)-Denobilone 2) as a enantiomers by chiral HPLC. absolute configurations determined comparing their experimental calculated electronic circular dichroism spectra....
Ten new cephalotane-type diterpenoids, cephanolides A-J (1-10), and two known analogues were isolated characterized from Cephalotaxus sinensis. Compounds 1-3 represent the first examples of A-ring-contracted dinorditerpenoids, compound 4 is an norditerpenoid. The biosynthetic pathways for compounds 1-4 are postulated with coexisting troponoids as precursors. 11 12 showed significant cytotoxicities against a panel tumor cell lines (A549, KB, HL-60, HT-29) IC50 values ranging 0.464 to 6.093 μM.
Four new 9',10'-dihydro-biphenanthrenes, including an unprecedented 1,2'-linked biphenanthrene, 4,7,3',5'-tetramethoxy-9',10'-dihydro(1,2'-biphenanthrene)-2,7'-diol (1), a 1,3'-linked 4,7,7'-trimethoxy-9',10'-dihydro(1,3'-biphenanthrene)-2,2',5'-triol (2), and two 1,1'-linked biphenanthrenes, 4,7,4'-trimethoxy-9',10'-dihydro(1,1'-biphenanthrene)-2,2',7'-triol (3) 4,7,3',5'-tetramethoxy-9',10'-dihydro(1,1'-biphenanthrene)-2,2',7'-triol (4), as well known biphenanthrenes (5, 6), were isolated...
Four polycyclic norditerpenoids, cephalotanins A-D (1-4) representing three unprecedented carbon skeletons with highly rigid ring systems, were isolated from Cephalotaxus sinensis and structurally characterized by a combination of various methods. Compounds 1 2 are new skeletal norditerpenoid trilactones, while 3 4 two norditerpenoids featuring different skeletons. Biosynthetic pathways for 1-4 proposed involving diverse very fascinating chemical events the coexisting cephalotane troponoids...
Five new diterpenoids including two Cephalotaxus troponoids (1 and 2), 17-nor-cephalotane-type (3 4), an abietane-type diterpenoid (5), lignans (6 7), a trisnorneoligan (8) along with eight known compounds were identified from the twigs leaves of fortunei. The structure 11-hydroxyhainanolidol was revised as 10-hydroxyhainanolidol (9) by X-ray crystallographic data. Compounds 3 4 are first examples that likely biosynthesis precursors co-occurring (e.g., 1, 2, 9). Compound 1 exhibited...
IL-1β produced by macrophages via the NOD-, LRR- and pyrin domain-containing 3 (NLRP3) inflammasome, mediates inflammatory crosstalk between adipocytes. In our previous study, (16S,20S,24R)-12β-acetoxy-16,23-epoxy-24,25-dihydroxy-3β-(β-D-xylopyranosyloxy)-9,19-cyclolanost-22(23)-ene (AEDC), a cycloartane triterpenoid isolated from Actaea vaginata (Ranunculaceae), was found to possess anti-inflammatory effect on LPS-treated RAW264.7 macrophages. This study designed investigate whether AEDC...
Phytochemical investigation of the root tubers Lindera aggregata resulted in isolation five new sesquiterpene lactones, linderagalactones A−E (1−5), along with eight known sesquiterpenoids, 3-eudesmene-1β,11-diol, hydroxylindestenolide, strychnistenolide, hydroxyisogermafurenolide, atractylenolide III, linderane, neolinderalactone, and linderalactone. The structures relative configurations 1−5 were determined by spectroscopic methods, especially HRESIMS 2D NMR techniques. absolute 1−4...
Logeracemin A (1), the first Daphniphyllum alkaloid dimer featuring an unprecedented carbon skeleton with a unique conjugated trispiro[4,5] decane backbone, was isolated from longeracemosum. Its structure and absolute configuration were established on basis of spectroscopic data X-ray crystallography. showed significant anti-HIV activity EC50 4.5 ± 0.1 μM selectivity index 6.2. The structure-activity relationship tested compounds briefly discussed.
Three new 14-membered resorcylic acid lactones, cochliomycins D-F, 1-3, and eight known analogues, 4-11, were isolated from the sea anemone-derived fungus Cochliobolus lunatus. Compounds 1-4 are diastereomers differing each other by absolute configurations of 4',5'-diol chiral centers. The established CD exciton chirality method TDDFT ECD calculations. In antifouling assays, 1, 3-6, 6a exhibited potent activities against larval settlement barnacle Balanus amphitrite at nontoxic...
Phainanolide A (1), a highly modified triterpenoid incorporating an unprecedented 6/9/6 heterotricyclic system and oxygenated 5,5-spirocyclic ketal lactone, along with three new triterpenoids 2–4 were isolated from Phyllanthus hainanensis. Their structures completely elucidated by combination of diverse methods including 2D NMR, quantum chemical NMR ECD calculations, data analogy model compounds. Compounds 1–4 exhibited both remarkable cytotoxic immunosuppressive activities.
Two novel cyclodepsipeptides containing an unusual anthranilic acid dimer and a D-phenyllactic residues, clavatustides A B, were identified from cultured mycelia broth of Aspergillus clavatus C2WU isolated Xenograpsus testudinatus, which lives at extreme, toxic habitat around the sulphur-rich hydrothermal vents in Taiwan Kueishantao. This is first example cyclopeptides natural products, report microbial secondary metabolites vent crab. Clavatustides B suppressed proliferation hepatocellular...
Eucalyptin A (1), together with two known compounds 2 and 3 exhibiting potent inhibition on HGF/c-Met axis, was discovered from the fruits of Eucalyptus globulus. 1 possessed an unprecedented carbon framework phloroglucinol-coupled sesquiterpenoid, its structure elucidated by spectroscopic method ECD calculation. brief structure-activity relationship discussion indicated that coupling a phloroglucinol sesquiterpenoid is essential for activity.
Twelve new chromone derivatives, corynechromones A–L (1–12), were isolated from the sponge-derived fungus Corynespora cassiicola XS-200900I7. Among them, 1/2, 3/4, 5/6, and 7/8 pairs of epimers. The planar structures determined by extensive NMR spectroscopic data. absolute configurations 1–10 assigned modified Mosher's method TDDFT ECD calculations together with comparison their CD spectra. These are first derivatives reported genus Corynespora. A possible rule to determine at C-2 in was proposed.