A5056789044- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Bioactive Natural Diterpenoids Research
- Natural product bioactivities and synthesis
- Phytochemical compounds biological activities
- Hepatocellular Carcinoma Treatment and Prognosis
- Marine Sponges and Natural Products
- Biological Activity of Diterpenoids and Biflavonoids
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Traditional and Medicinal Uses of Annonaceae
- Sesquiterpenes and Asteraceae Studies
- Plant Toxicity and Pharmacological Properties
- Nanoparticle-Based Drug Delivery
- Cancer therapeutics and mechanisms
- Phytochemistry and Bioactive Compounds
- Cancer, Lipids, and Metabolism
- Bioactive Compounds and Antitumor Agents
- RNA Interference and Gene Delivery
- Crystallography and molecular interactions
- Malaria Research and Control
- Essential Oils and Antimicrobial Activity
- Phytochemistry and Biological Activities
- Synthesis and biological activity
- Phytochemistry and Bioactivity Studies
- Lung Cancer Treatments and Mutations
Shanghai Institute of Materia Medica
2012-2024
Chinese Academy of Sciences
2012-2024
Shandong Provincial Hospital
1998-2022
Shandong University
2020-2022
Dongfeng Motor Group (China)
2022
University of South China
2019-2022
Shandong Normal University
2021
Beijing University of Technology
2019
University of Chinese Academy of Sciences
2016
Qilu Hospital of Shandong University
2009
Inspired by the discovery of antimalarial drug artemisinin from a traditional Chinese medicine (TCM), natural product library 44 lindenane-type sesquiterpenoids was assessed for activities against Dd2 chloroquine-resistant strain malaria parasite Plasmodium falciparum. These compounds were mainly isolated plants Chloranthus genus, many species which are named "Sikuaiwa" in TCM and have long been used to treat malaria. The consisted 41 sesquiterpenoid dimers three monomers, including 12 new...
Fourteen new diterpenoids including clerodane (1–12), labdane (13), and norlabdane (14) types, as well nine known analogues were isolated from the aerial parts of Croton laui. Their structures established on basis spectroscopic analysis, that crotonolide H (11) was confirmed by single-crystal X-ray crystallography. Crotonolide A (1) exhibited moderate cytotoxicity against two tumor cell lines, HL-60 (human premyelocytic leukemia, IC50 9.42 μM) P-388 (murine 7.45 μM), G (10) displayed...
Five new diterpenoids including two Cephalotaxus troponoids (1 and 2), 17-nor-cephalotane-type (3 4), an abietane-type diterpenoid (5), lignans (6 7), a trisnorneoligan (8) along with eight known compounds were identified from the twigs leaves of fortunei. The structure 11-hydroxyhainanolidol was revised as 10-hydroxyhainanolidol (9) by X-ray crystallographic data. Compounds 3 4 are first examples that likely biosynthesis precursors co-occurring (e.g., 1, 2, 9). Compound 1 exhibited...
Seventeen new 17- nor-cephalotane-type diterpenoids, fortalpinoids A-Q (1-17), were isolated from the seeds of Cephalotaxus fortunei var. alpine. Compound 12 represents first diterpenoid featuring an 8-oxabicyclo[3.2.1]oct-2-ene moiety. The absolute configuration fortunolide A (18) was determined for time, and structure cephinoid Q revised to 14- epi-cephafortoid (24) by X-ray crystallographic data analysis. Some compounds showed significant cytotoxicity against A549 HL-60 cells,...
Alzheimer's disease (AD) involves multiple pathological factors that mutually cooperate and closely contact to form interaction networks for jointly promoting the AD progression. Therefore, comonitoring of different is particularly valuable elucidating their level dynamics complex interactions. However, such significant investigations remain a major challenge due lack unimolecular fluorescent probes capable simultaneous discriminative visualization targets. To address this concern, as proof...
Phainanolide A (1), a highly modified triterpenoid incorporating an unprecedented 6/9/6 heterotricyclic system and oxygenated 5,5-spirocyclic ketal lactone, along with three new triterpenoids 2–4 were isolated from Phyllanthus hainanensis. Their structures completely elucidated by combination of diverse methods including 2D NMR, quantum chemical NMR ECD calculations, data analogy model compounds. Compounds 1–4 exhibited both remarkable cytotoxic immunosuppressive activities.
Three new ring B-seco limonoids, ciliatonoids A–C (1–3), were isolated from Toona ciliate and structurally characterized by spectroscopic data, X-ray crystallography, electronic circular dichroism analysis. Ciliatonoids A B feature an unprecedented limonoid architecture, while ciliatonoid C belongs to a rare class of limonoids. Biological evaluation showed that compound 3 exhibited modest activities against the tested tumor cell lines.
Chemical investigation of an EtOH extract the twigs and leaves Croton damayeshu afforded 10 new tigliane diterpenoids, crodamoids A–J (1–10), along with five known compounds. Their structures were elucidated by physical data analysis. Compounds 8, 9, 15 displayed cytotoxic effects against two human tumor cell lines, A549 HL-60 (IC50: 0.9–2.4 μM).
Crokonoid A (1), a highly rearranged diterpenoid featuring dual-bridged tricyclo[4.4.1.11,4]dodecane-2,11-dione ring system and its two possible ent-kaurene precursors (2 3), was isolated structurally characterized by solid data from Croton kongensis. Compound 1 exhibited significant cytotoxicity against HL-60 A-549 cell lines with IC50 values of 1.24 ± 0.56 1.92 0.60 μM, respectively.
Abstract From the dried roots of Euphorbia nematocypha , eight new diterpenoids, with ent ‐atisane ( i.e. 1 – 5 ) and isopimarane 6 8 type skeletons, together five known compounds, were isolated. The structures these compounds elucidated by spectroscopic data. Compounds evaluated for their cytotoxicity against a small panel human cancer cell lines.
Six new diterpenoids, 1–6, a prenylated sesquiterpenoid, 7, and six known compounds were isolated from Trigonostemon heterophyllus. The structures of 1–7 elucidated on the basis NMR MS analysis. daphnane diterpenoids trigoheterins A (1) B (2) possess rare 4,6-oxetane moiety within this compound class, trigoheteric acid methyl ester (6) is first example 15,16-dinor-3,4-seco-cleistanthane. Trigoheterin E (5) exhibited cytotoxic activity against HL-60 (IC50 1.8 μM) A-549 10.0 human cancer cell lines.
Nine new daphnane-type diterpenoids (1–9), named trigohownins A–I, and four known analogues were isolated from Trigonostemon howii. Their structures elucidated on the basis of extensive NMR MS analyses. Trigohownins A (1) D (4) exhibited moderate cytotoxic activity against HL-60 tumor cell line, with IC50 values 17.0 9.3 μM, respectively.
Chemical investigation into the twigs and leaves of Sapium insigne afforded seven new diterpenoids, sapinsignoids A–G (1–7), together with 10 known diterpenoids. The structures 1–7 were assigned on basis detailed spectroscopic analysis chemical degradation. Compounds 1–4 exhibited significant cytotoxicity against A-549 tumor cell line (IC50 0.2–1.8 μM), while compounds 1–3 showed moderate HL-60 2.7–6.5 μM).
Ainsliatriolides A (1) and B (2), two guaianolide sesquiterpenoid trimers possessing an unprecedented skeleton, were isolated from Ainsliaea fragrans. Their structures elucidated through extensive analysis of spectroscopic data confirmed by single-crystal X-ray diffraction experiment. are first examples compound trimerized sesquiterpenoids different C–C linkages (type A, 4–2′/15–14′; type B, 15′-15″). Ainsliatriolide displayed potent cytotoxicity with averaged IC50 value 1.17 μM against four...
Ten new sesquiterpene lactones, carlipsines A–J (1–10), and 12 known analogues (11–22) were isolated from the whole plant of Carpesium lipskyi. Their structures elucidated by using 1D 2D NMR HRESIMS analyses, their absolute configurations confirmed X-ray diffraction studies. All compounds identified as germacranolides with diverse substructural features. Compounds 1–4 are 2,5-hemiacetal-linked germacranolides. 5 6 possess a 1,2-epoxy moiety. 7 8 represent unusual 1,5-hemiacetal-linked 9 10...