A5009180859- Natural product bioactivities and synthesis
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Phytochemical compounds biological activities
- Traditional and Medicinal Uses of Annonaceae
- Bioactive Natural Diterpenoids Research
- Phytochemistry and Biological Activities
- Alkaloids: synthesis and pharmacology
- Essential Oils and Antimicrobial Activity
- Phytochemistry and Bioactive Compounds
- Plant chemical constituents analysis
- Biological Activity of Diterpenoids and Biflavonoids
- Cholesterol and Lipid Metabolism
- Microbial Metabolites in Food Biotechnology
- Plant biochemistry and biosynthesis
- Kidney Stones and Urolithiasis Treatments
- Drug Transport and Resistance Mechanisms
- Therapeutic Uses of Natural Elements
- Ginger and Zingiberaceae research
- Adipokines, Inflammation, and Metabolic Diseases
- Phytochemistry and Bioactivity Studies
- Phytochemicals and Medicinal Plants
- Marine Sponges and Natural Products
- Diet and metabolism studies
- Bamboo properties and applications
Xishuangbanna Tropical Botanical Garden
2015-2025
Chinese Academy of Sciences
2014-2024
Shanghai Institute of Materia Medica
2018-2023
University of Chinese Academy of Sciences
2014-2022
Yunnan University of Traditional Chinese Medicine
2013
Abstract Dietary fiber has been shown to prevent high-fat diet induced obesity through modulating the gut microbiota; however, quality difference in type is largely unknown. We performed a 6 week study on C57BL/6J mice fed macronutrient matched with different types including cellulose (HFC), bamboo shoot (HFBS) and several other commonly consumed fibers. Our results showed that HFBS group exhibited lowest weight gain among all groups had improved lipid profiles glycemic control compared HFC...
A 17-membered macrocyclolipopeptide, named dysoxylactam (1) comprising an unprecedented branched C19 fatty acid and l-valine, was isolated from the plants of Dysoxylum hongkongense. The challenging relative configuration 1 established by means residual dipolar coupling-based NMR analysis. absolute determined single-crystal X-ray diffraction on its p-bromobenzoate derivative (2). Compound dramatically reversed multidrug resistance in cancer cells with fold-reversals ranging 28.4 to 1039.7 at...
Ten quinoline alkaloids from Zanthoxylum avicennae , of which 1 possesses an unusual structure and 6 exhibits anti-inflammatory effect in macrophages.
A new class of potent liver injury protective compounds, phychetins A−D (1−4) featuring an unique 6/6/5/6/5 pentacyclic framework, were isolated and structurally characterized from a Chinese medicinal plant Phyllanthus franchetianus. Compounds 2−4 are three pairs enantiomers that initially obtained in racemic manner, further separated by chiral HPLC preparation. 1−4 proposed to be originated biosynthetically coexisting lignan via intramolecular Friedel–Crafts reaction as the key step....
Nine new cedrelone limonoids, namely, walsuranolide B (1), 11β-hydroxy-23-O-methylwalsuranolide (2), yunnanolide A (3), yunnanol (4), 11β-hydroxyisowalsuranolide (5), 11β-hydroxy-1,2-dihydroisowalsuranolide (6), 1α,11β-dihydroxy-1,2-dihydroisowalsuranolide (7), 11β-hydroxy-1α-methoxy-1,2-dihydroisowalsuranolide (8), and (9), together with a cycloartane triterpenoid, (24S*,25R*)-cycloartane-3β,24,25,26-tetrol (10), were isolated from the leaves twigs of Walsura yunnanensis. Their structures...
Chemical investigation of an EtOH extract the twigs and leaves Croton damayeshu afforded 10 new tigliane diterpenoids, crodamoids A–J (1–10), along with five known compounds. Their structures were elucidated by physical data analysis. Compounds 8, 9, 15 displayed cytotoxic effects against two human tumor cell lines, A549 HL-60 (IC50: 0.9–2.4 μM).
Eleven densely functionalized new dihydro-β-agarofuran sesquiterpenoid derivatives, named maytenoids A-K (1-11), as well one known analog, were isolated and characterized from Maytenus austroyunnanensis. Their structures assigned based on analysis of spectroscopic data X-ray crystallography. Compounds 1-9 are macrocyclic sesquiterpene pyridine alkaloids generated by the respective acylation hydroxy groups at C-3 C-13 sesquiterpenoids via diverse dicarboxylic acids. 1, 2, 5-10, 12 exhibited...
Open AccessCCS ChemistryRESEARCH ARTICLE1 Feb 2021Macrocyclic Nonapeptides Incorporating Uncharacterized Amino Acids with Inhibitory Effects on Th17 Differentiation Kai-Long Ji, Yao-Yue Fan, Hio-Ha Kuok, Qun-Fang Liu, Ting Li and Jian-Min Yue Ji State Key Laboratory of Drug Research, Shanghai Institute Materia Medica, Chinese Academy Sciences, 201203 , Fan Kuok Quality Research in Medicines, Macau for Applied Medicine Health, University Science Technology, 999078 Liu *Corresponding author:...
Comprehensive Summary Five unreported and oxygenated ent ‐rosane diterpenoids ( ‐RDs), Euphomillanols A—E 1 — 5 ), were isolated from Euphorbia milii . Among them, compounds 2 are unprecedented 7/7/6‐fused tricyclic 5,10‐seco‐ ‐RDs possess a unique 11‐oxabicyclo[4.4.1]undeca‐1(10),5‐diene moiety, while 3 is characterized by 1‐methyl‐6‐oxabicyclo[3.2.1]oct‐2‐ene motif of ring A. Their structures with absolute configurations unambiguously determined the extensive spectroscopic methods, X‐ray...
Four highly rearranged labdane-type diterpenoids, maximumins A–D (1–4) possessing different new carbon skeletons, together with a biosynthetically related known analog 5 were isolated from Amomum maximum. The structures of compounds absolute configurations characterized by spectroscopic and computational approaches. plausible biogenetic pathways for 1–4 proposed. These showed moderate to weak activities against nuclear factor kappa B (NF-κB).
Two new limonoids, namely 14,15-didehydroruageanin A (1) and 3-O-methyl- butyrylseneganolide (2), were isolated from the fruits of Khaya ivorensis along with six known limonoids: seneganolide (3), 1,3-dideacetylkhivorin (4), 7-deacetylkhivorin (5), 3-deacetylkhivorin (6), 1-deacetylkhivorin (7), 3-deacetyl-7-oxokhivorin (8). All compounds evaluated for their cytotoxicity against five tumor cell lines.
The 6-methoxy-cannabisin I (1), a new alkaloid, together with five known compounds oleraisoindole A (2), cannabisin F (3), apigenin (4), syringin (5) and ethyl-syringin (6) were isolated from Tinospora crispa stems. Their structures identified by the analysis of spectroscopic data. Compound 2 was T. for first time. Anti-inflammatory activity compound 1 detected against NO production in LPS-activated RAW 264.7 macrophages. However, no observed.
Alpinia hainanensis is an important food spice and ethnic medicine in Southwest China. In this study, we found that the EtOAc-soluble fraction (AHE) of A. rhizome ethanol extract could ameliorate dextran sulfate sodium-induced ulcerative colitis (UC). To explore active constituents, five pairs previously unreported enantiomers (1-5), together with nine known ones (6-14), were obtained. Structural characterization was achieved by comprehensive spectroscopic methods. Compounds 1 2 new...
One novel pentacyclic triterpene, 24-dimethoxymethyl-3β,6β,19α- trihydroxy -12-en-28-oic acid (1), along with six known compounds 2-7, were isolated from the canes of Uncaria sessilifructus Roxb. Their structures determined according to spectroscopic and spectrometric analysis. The anti-inflammatory activities (1-7) scanned against NO production in LPS-activated RAW 264.7 macrophages by MTS assay, however no observed.