A5028391313- Viral Infections and Immunology Research
- Environmental Toxicology and Ecotoxicology
- Cytomegalovirus and herpesvirus research
- Herpesvirus Infections and Treatments
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Cancer-related molecular mechanisms research
- Metabolomics and Mass Spectrometry Studies
- RNA Research and Splicing
- RNA and protein synthesis mechanisms
- DNA Repair Mechanisms
- Respiratory viral infections research
- Microbial Community Ecology and Physiology
- Toxic Organic Pollutants Impact
- Marine and coastal ecosystems
- Marine Biology and Environmental Chemistry
- Parvovirus B19 Infection Studies
- 14-3-3 protein interactions
- SARS-CoV-2 and COVID-19 Research
- Animal Virus Infections Studies
- Prion Diseases and Protein Misfolding
- Infection Control and Ventilation
- interferon and immune responses
- Bioactive Natural Diterpenoids Research
- Marine Bivalve and Aquaculture Studies
Guangxi Institute of Oceanography
2024
Ministry of Natural Resources
2024
Bengbu Medical College
2024
National Institute for Viral Disease Control and Prevention
2013-2023
Sun Yat-sen University
2018-2023
Tangshan Gongren Hospital
2013-2023
North China University of Science and Technology
2014-2023
Center for Disease Control
2013-2022
State Key Laboratory of Microbial Technology
2021-2022
Shaanxi Provincial Hospital of Traditional Chinese Medicine
2022
The phytochemical study of Euphorbia prolifera led to the isolation two tiglianes (1 and 2) 23 mysrinanes (3–25). Most these isolates showed significant antiadipogenic activity in 3T3-L1 adipocyte without apparent cytotoxicity. Subsequent structural modification yielded 10 derivatives, among which 1a, 5-O-acetyl derivative 1, turned out be most active compound with improved triglyceride-lowering (EC50 for 1 1a: 0.61 0.32 μM, respectively) reduced cytotoxicity (selectivity index 28 312,...
<sec> <b>What is already known about this topic?</b> </sec><sec> Though coronavirus disease 2019 (COVID-19) has largely been controlled in China, several outbreaks of COVID-19 have occurred from importation cases or suspected virus-contaminated products. traced to severe acute respiratory syndrome 2 (SARS-CoV-2) isolated on the outer packaging cold chain products, live virus not obtained. added by report?</b> In September 2020, two dock workers were detected as having asymptomatic SARS-CoV-2...
Background and Purpose Non‐alcoholic hepatic fatty liver disease (NAFLD) is a manifestation of the metabolic syndrome in non‐alcoholic steatohepatitis (NASH) represents its advanced stage. R17 derived from bouchardatine, shows benefits syndrome, but has not been tested liver. The present study examined pharmacological effects model NAFLD/NASH mode action. Experimental Approach were mice fed high‐fat (HF) diet to induce pathological characteristics cultures HuH7 cells. We used histological...
To understand the underlying mechanisms of endoplasmic reticulum (ER) stress caused by human rhinovirus (HRV) 16 and non-structural transmembrane protein 2B, expressions ER chaperone glucose-regulated 78 (GRP78) three signal transduction pathways, including kinase RNA-like (PERK), activating transcription factor 6 (ATF6) inositol-requiring enzyme 1 (IRE1), were evaluated after HRV16 infection 2B gene transfection. Our results showed that both transfection increased expression GRP78, induced...
Raptor, a regulatory-associated protein of mTOR, has been genetically proved to be an important regulator in lipogenesis. However, its druggable potential is rarely investigated, largely due the lack inhibitor. In this study, antiadipogenic screening daphnane diterpenoid library followed by target fishing led identification Raptor inhibitor, 1c (5/7/6 carbon ring with orthoester and chlorine functionalities). Pharmacodynamic studies verified that potent tolerable agent vitro vivo....
BackgroundPelvic floor muscle training (PFMT) is a first-line conservative therapy for stress urinary incontinence (SUI). Electroacupuncture (EA) has been used to treat SUI recently.ObjectiveTo compare the effectiveness of PFMT + EA versus sham in women.Design, setting, and participantsA prospective, multicenter, randomized, controlled clinical trial was conducted at four hospitals China involving 304 women with from May 20, 2014 November 21, 2017. Data were analyzed April 20 December...
Background CD55 plays an important role in the development of colon cancer. This study aims to evaluate expression cancer and discover how it is regulated by transcriptional factors miRNA. Methods The was explored TIMER2.0, UALCAN, Human Protein Atlas (HPA) databases. TRANSFAC Contra v3 were used predict potential binding sites transcription promoter. TargetScan starBase v2.0 ability miRNAs 3′ untranslated region (3′UTR) . SurvivalMeth explore differentially methylated Western blotting...
XPA-binding protein 2 (XAB2) interacts with Cockayne syndrome complementation group A (CSA), B (CSB) and RNA polymerase II to initiate nucleotide excision repair. This study aims evaluate the association of XAB2 genetic variants risk non-small cell lung cancer (NSCLC) using a tagging approach. hospital-based case-control was conducted in 470 patients NSCLC controls Chinese population. Totally, 5 tag single polymorphisms (SNPs) gene were selected by Haploview software Hapmap database....
Marine Synechococcus are an ecologically important picocyanobacterial group widely distributed in various oceanic environments. Little is known about the dynamics and distribution of abundance genotypes during seasonal hypoxia coastal zones. In this study, investigation was conducted a marine ranch along two transects Muping, Yantai, where hypoxic events (defined here as dissolved oxygen concentration <3 mg L−1) occurred summer 2015. The bottom waters from late July persisted until...
This study assessed the incidence and resistance of Mycoplasma pneumoniae (MP) in children Qingdao, China, 2019.We detected MP infection 78 pharyngeal swabs from with pneumonia by qPCR. The RepMP4 element P1 adhesin gene, domain V 23S rRNA L4/L22 ribosomal proteins were amplified nested PCR. Evolutionary analysis was conducted based on gene sequence. Resistance mutations analysed.The 59.0% (46/78). mean duration longer than that non-MP infection. According to sequencing 21 samples, 12...
Comprehensive Summary Five unreported and oxygenated ent ‐rosane diterpenoids ( ‐RDs), Euphomillanols A—E 1 — 5 ), were isolated from Euphorbia milii . Among them, compounds 2 are unprecedented 7/7/6‐fused tricyclic 5,10‐seco‐ ‐RDs possess a unique 11‐oxabicyclo[4.4.1]undeca‐1(10),5‐diene moiety, while 3 is characterized by 1‐methyl‐6‐oxabicyclo[3.2.1]oct‐2‐ene motif of ring A. Their structures with absolute configurations unambiguously determined the extensive spectroscopic methods, X‐ray...