A5101433403- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Drug-Induced Hepatotoxicity and Protection
- Organ Transplantation Techniques and Outcomes
- Nutrition and Health in Aging
- Hepatitis Viruses Studies and Epidemiology
- Catalysis and Oxidation Reactions
- Catalytic Processes in Materials Science
- Zeolite Catalysis and Synthesis
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Inflammatory Biomarkers in Disease Prognosis
- SARS-CoV-2 detection and testing
- Genetics and Neurodevelopmental Disorders
- Boron Compounds in Chemistry
- Bioinformatics and Genomic Networks
- SARS-CoV-2 and COVID-19 Research
- Vaccine Coverage and Hesitancy
- Neurological Disorders and Treatments
- Liver physiology and pathology
- Cardiac Ischemia and Reperfusion
- Ferroptosis and cancer prognosis
- Thyroid Cancer Diagnosis and Treatment
- Vitamin C and Antioxidants Research
Children’s Hospital of Fudan University Xiamen Branch
2025
China National Petroleum Corporation (China)
2024
Second Affiliated Hospital of Xi'an Jiaotong University
2020-2024
First Affiliated Hospital of Xi'an Jiaotong University
2018-2023
Sichuan University
2022
West China Hospital of Sichuan University
2022
Xi'an Jiaotong University
2019-2021
National Institute for Viral Disease Control and Prevention
2021
Xuzhou Medical College
2015
Wuhan Medical Center for Women and Children
2015
The European Society for Clinical Nutrition and Metabolism (ESPEN) guidelines recommend the Royal Free Hospital-Nutritional Prioritizing Tool (RFH-NPT) to identify malnutrition risk in patients with liver disease. However, little is known about application of RFH-NPT screen China, where primarily suffer from hepatitis virus-related cirrhosis. A total 155 cirrhosis without cancer or uncontrolled co-morbid illness were enrolled this prospective study. We administered Nutritional Risk Screening...
Liver sinusoids serve as the first line of defense against extrahepatic stimuli from intestinal tract. Hepatic stellate cells (HSCs) are pericytes residing in perisinusoidal space that integrate cytokine-mediated inflammatory responses and relay these signals to liver parenchyma. Oxidative stress has been shown promote inflammation during acute failure (ALF). Whether how oxidative is involved HSC ALF remains unclear. Level systemic reflected by superoxide dismutase (SOD). Thus, patients were...
<sec> <b>What is already known about this topic?</b> </sec><sec> Though coronavirus disease 2019 (COVID-19) has largely been controlled in China, several outbreaks of COVID-19 have occurred from importation cases or suspected virus-contaminated products. traced to severe acute respiratory syndrome 2 (SARS-CoV-2) isolated on the outer packaging cold chain products, live virus not obtained. added by report?</b> In September 2020, two dock workers were detected as having asymptomatic SARS-CoV-2...
Hepatocellular carcinoma (HCC) is sexually disparate in humans, with a significantly increased prevalence males. The molecular mechanisms by which the inhibition or development of liver cancer are facilitated require further investigation regard to sex factors affecting disease progression. In present study, functional signatures differentially expressed genes (DEGs) were screened female and male tumors via bioinformatics analysis. following gene chip expression profiles downloaded from Gene...
Fewer than 50% of patients with acute-on-chronic liver failure (ACLF) recover spontaneously, and ACLF has high mortality without transplantation. Oxidative stress been shown to mediate hepatic inflammation during acute (ALF). We wanted see if a biomarker for oxidative might be used measure the severity prognosis patients.A retrospective cohort 124 patients, as well healthy individuals, cirrhosis ALF was studied between January 2015 September 2018. The levels plasma superoxide dismutase (SOD)...
Viral hepatitis E clinically ranges from self-limiting to lethal liver failure. Oxidative stress has been shown mediate hepatic inflammation during HBV-induced We investigated whether a biomarker of oxidative may be helpful in assessing severity and disease outcomes patients with HEV-induced failure.Clinical data were obtained acute viral (AVH, n = 30), failure (ALF, 17), acute-on-chronic (ACLF, 36), as well healthy controls (HC, 30). The SOD HMGB1 levels measured serum by ELISA. HL-7702...
Rare-earth-promoted zeolites have broad applications in the petrochemical industry because modifying with rare-earth elements can remarkably improve hydrothermal stability and tune physicochemical properties of acid sites, resulting substantial promotion catalytic selectivity long-term stability. However, for a specific reaction, it remains challenge to elaborate coordination environment within zeolite structure establish structure–reactivity rare-earth-promoted catalysts. In this work, we...
Hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is the most prevalent type of ACLF in China. The mortality rate HBV-ACLF has decreased recent years due to advances treatment therapies; however, it still above 50%. Many cases are caused by HBV reactivation discontinuation nucleoside analog treatment. present study focused on plasma levels superoxide dismutase (SOD) patients and investigated whether level SOD a useful biomarker assessing disease severity predicting outcomes...
There is an increasing evidence indicating the involvement of sympathetic nervous system (SNS) in liver disease development. To achieve extensive comprehension obscure process by which SNS alleviates inflammatory damage non-parenchymal cells (NPCs) during acute failure (ALF), we employ isoproterenol (ISO), a beta-adrenoceptor agonist, to mimic signaling. ISO was administered C57BL/6J mice establish (ALF) model using LPS/D-GalN, defined as + ALF. Non-parenchymal were isolated from tissues and...
Objectives To evaluate the performance and cost-effectiveness of existing diabetes risk scores (DRSs) to screen for undiagnosed mellitus (UDM) prediabetes (PD) in a community-based southwestern Chinese population.Methods Participants TIDE-Chengdu survey with requisite data without known were included. Five Chinese-derived DRSs six non-Chinese-derived included evaluation. Their detecting UDM UMD or PD (UDM/PD) was assessed using C-statistic. The optimal DRS compared that capillary fasting...
Abstract Alanine aminotransferase (ALT) flare remains one of the determinants initiating antiviral therapy in children with chronic hepatitis B (CHB). Insufficient data exist regarding CHB attributed to mother‐to‐child transmission. This study aimed assess occurrence spontaneous ALT flares and identify factors affecting therapy‐induced surface antigen (HBsAg) loss cohort. We retrospectively included untreated transmitted CHB. The primary outcomes were HBsAg loss. Among 83 children, 73.5%...
To investigate the prevalence of thyroid disorders, iodine nutritional status and relevant risk factors among adults in Chengdu city on basis two population-based surveys, one conducted between 2016 2017 other, 2019 2020, to provide references for making health-related administrative decisions.Two sampling surveys were conducted. The first was done October December 2017, using stratified cluster random select subjects from 2 urban rural communities Chengdu. Then, February sequential used...
This study aimed to explore the association of globulin and albumin-to-globulin ratio (AGR) with diabetic kidney disease (DKD) retinopathy (DR) in patients type 2 diabetes mellitus (T2DM).
Background There have been increasing reports of HBV reactivation in and HCV coinfected patients with direct-acting antiviral (DAA) treatment. The potential risk undergoing haemodialysis has also noted. is a lack data pertaining to the during DAA treatment those end-stage renal disease who are haemodialysis. Methods HBV–HCV-coinfected were screened from 178 persons at two blood purification centres China received sofosbuvir (200 mg) combined daclatasvir (60 daily. pattern was retrospectively...
Hemorrhagic fever with renal syndrome (HFRS) is a disease increased systemic inflammation and high fatality rate. Oxidative stress crucial for in the pathogeneses of various diseases. We aimed to identify biomarkers oxidative that may assess severity outcomes patients HFRS.Between January 2015 September 2018, we analyzed retrospective cohort 149 HFRS 30 healthy individuals. Serum levels SOD were measured using an ELISA commercial kit, survival analysis was carried out Kaplan-Meier...
Background Tenofovir disoproxil fumarate (TDF) administration in the third trimester for pregnant women with high HBV DNA load has been accepted as a wise practice to prevent mother-to-infant transmission (MTIT). However, those who missed optimal time window of antiviral prophylaxis, this treatment is lacking current clinical guidelines. Methods Forty-eight did not receive prophylaxis before 28 weeks gestation were screened and administrated TDF plus hepatitis B immunoglobulin (HBIG;...
To determine whether the monocyte-to-lymphocyte ratio (MLR), as a systemic inflammation index, predicts malnutrition risk during early stages of cirrhosis.We conducted single-center prospective cohort study, enrolling patients from June 2016 to September 2020. The underwent assessments upon admission. were classified into five clinical according portal hypertension. was scored using Royal Free Hospital-Nutritional Prioritizing Tool (RFH-NPT) and validated by Nutritional Risk Screening 2002...