A5090732377- Hepatitis B Virus Studies
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Hepatitis Viruses Studies and Epidemiology
- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Drug-Induced Hepatotoxicity and Protection
- Autophagy in Disease and Therapy
- Folate and B Vitamins Research
- Hemoglobinopathies and Related Disorders
- Extracellular vesicles in disease
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Occupational exposure and asthma
- Viral Infections and Vectors
- Cardiomyopathy and Myosin Studies
- Drug Transport and Resistance Mechanisms
- Vaccine Coverage and Hesitancy
- Vitamin C and Antioxidants Research
- Fire effects on ecosystems
- Endoplasmic Reticulum Stress and Disease
- Pregnancy and Medication Impact
- Inflammatory Biomarkers in Disease Prognosis
- Bioinformatics and Genomic Networks
- Hip and Femur Fractures
First Affiliated Hospital of Xi'an Jiaotong University
2017-2025
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2024-2025
Xi'an Jiaotong University
2017-2021
First Hospital of Xi'an
2019
Peking University First Hospital
2019
Peking University
2019
The European Society for Clinical Nutrition and Metabolism (ESPEN) guidelines recommend the Royal Free Hospital-Nutritional Prioritizing Tool (RFH-NPT) to identify malnutrition risk in patients with liver disease. However, little is known about application of RFH-NPT screen China, where primarily suffer from hepatitis virus-related cirrhosis. A total 155 cirrhosis without cancer or uncontrolled co-morbid illness were enrolled this prospective study. We administered Nutritional Risk Screening...
Liver sinusoids serve as the first line of defense against extrahepatic stimuli from intestinal tract. Hepatic stellate cells (HSCs) are pericytes residing in perisinusoidal space that integrate cytokine-mediated inflammatory responses and relay these signals to liver parenchyma. Oxidative stress has been shown promote inflammation during acute failure (ALF). Whether how oxidative is involved HSC ALF remains unclear. Level systemic reflected by superoxide dismutase (SOD). Thus, patients were...
Approximately two-thirds of hepatocellular carcinoma (HCC) is considered a "cold tumor" characterized by few tumor-infiltrating T cells and an abundance immunosuppressive cells. Cilengitide, integrin αvβ3 inhibitor, has failed in clinical trials as potential anticancer drug. This failure implies that may play important role immune However, the expression HCC patients remain unknown. Here, we established two models found cilengitide had dual effect on microenvironment exerting both antitumor...
The seroprevalence of hepatitis B virus (HBV) and its impact on pregnancy outcomes women from Shaanxi Province (China) was assessed. Risk factors for mother-to-child transmission (MTCT) were evaluated based HBV-related data. Viral markers biochemical parameters assessed in HBsAg-positive mothers their infants out 13,451 cases recruited. A pretested structured questionnaire used to test the general HBV knowledge. Descriptive statistics logistic regression analysis done reveal possible risk...
Hepatocellular carcinoma (HCC) is sexually disparate in humans, with a significantly increased prevalence males. The molecular mechanisms by which the inhibition or development of liver cancer are facilitated require further investigation regard to sex factors affecting disease progression. In present study, functional signatures differentially expressed genes (DEGs) were screened female and male tumors via bioinformatics analysis. following gene chip expression profiles downloaded from Gene...
Fewer than 50% of patients with acute-on-chronic liver failure (ACLF) recover spontaneously, and ACLF has high mortality without transplantation. Oxidative stress been shown to mediate hepatic inflammation during acute (ALF). We wanted see if a biomarker for oxidative might be used measure the severity prognosis patients.A retrospective cohort 124 patients, as well healthy individuals, cirrhosis ALF was studied between January 2015 September 2018. The levels plasma superoxide dismutase (SOD)...
Abstract Mother‐to‐child transmission (MTCT) is a major obstacle in the elimination of hepatitis B virus (HBV) infection. Telbivudine (LdT) and tenofovir disoproxil fumarate (TDF) are two most common antiviral medicines for preventing MTCT. However, efficacy safety LdT TDF HBV vertical during second to third trimester have not been compared rigorously. Therefore, we carried out prospective multicentre cohort study chronic mothers with DNA > 10 6 IU/mL, receiving or trimester. Among 893...
Viral hepatitis E clinically ranges from self-limiting to lethal liver failure. Oxidative stress has been shown mediate hepatic inflammation during HBV-induced We investigated whether a biomarker of oxidative may be helpful in assessing severity and disease outcomes patients with HEV-induced failure.Clinical data were obtained acute viral (AVH, n = 30), failure (ALF, 17), acute-on-chronic (ACLF, 36), as well healthy controls (HC, 30). The SOD HMGB1 levels measured serum by ELISA. HL-7702...
Intrahepatic cholestasis of pregnancy (ICP) is characterized by skin pruritus and impaired liver function. Hepatitis B virus (HBV) infection increases the risk developing ICP. HBV associated with oxidative stress, which has been proven to participate in development The goal this study was explore relationship among HBV, ICP, investigate whether a biomarker stress may predict diagnosis severity ICP.We induced retrospective cohort 70 ICP patients from January 2019 December 2020, compared their...
Objectives This study aimed to evaluate the efficacy and safety of long-term postpartum tenofovir disoproxil fumarate (TDF) therapy in hepatitis B virus (HBV)-infected mothers with high viral load. Methods In this retrospective cohort study, HBV-infected HBV DNA>2 × 10 5 IU/mL who initiated TDF prophylaxis treatment during pregnancy were divided into continuation discontinuation groups according whether they stopped within 3 months after birth or not. Virological biochemical markers...
Hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is the most prevalent type of ACLF in China. The mortality rate HBV-ACLF has decreased recent years due to advances treatment therapies; however, it still above 50%. Many cases are caused by HBV reactivation discontinuation nucleoside analog treatment. present study focused on plasma levels superoxide dismutase (SOD) patients and investigated whether level SOD a useful biomarker assessing disease severity predicting outcomes...
Background. Inflammation is a critical factor in the development and progression of myocardial infarction cardiac fibrosis. Thymosin β4 (Tβ4) alleviates disease process via protective antioxidant anti-inflammatory mechanisms. Although Tβ4 has been shown to have effect infarction, its impact on fibrosis not well reported. In this study, we evaluated influence exogenous explored possible underlying mechanism. Methods. Real-time quantitative reverse-transcription PCR (qRT-PCR),...
Abstract Alanine aminotransferase (ALT) flare remains one of the determinants initiating antiviral therapy in children with chronic hepatitis B (CHB). Insufficient data exist regarding CHB attributed to mother‐to‐child transmission. This study aimed assess occurrence spontaneous ALT flares and identify factors affecting therapy‐induced surface antigen (HBsAg) loss cohort. We retrospectively included untreated transmitted CHB. The primary outcomes were HBsAg loss. Among 83 children, 73.5%...
Background There have been increasing reports of HBV reactivation in and HCV coinfected patients with direct-acting antiviral (DAA) treatment. The potential risk undergoing haemodialysis has also noted. is a lack data pertaining to the during DAA treatment those end-stage renal disease who are haemodialysis. Methods HBV–HCV-coinfected were screened from 178 persons at two blood purification centres China received sofosbuvir (200 mg) combined daclatasvir (60 daily. pattern was retrospectively...
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