A5077832069- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Liver Disease and Transplantation
- Lattice Boltzmann Simulation Studies
- Liver physiology and pathology
- Heat Transfer and Optimization
- Aerosol Filtration and Electrostatic Precipitation
- Hepatitis Viruses Studies and Epidemiology
- Autophagy in Disease and Therapy
- Heat Transfer and Boiling Studies
- Food Allergy and Anaphylaxis Research
- Organ Transplantation Techniques and Outcomes
- COVID-19 and Mental Health
- COVID-19 epidemiological studies
- Fluid Dynamics and Turbulent Flows
- Smart Grid Security and Resilience
- Endoplasmic Reticulum Stress and Disease
- Cancer-related gene regulation
- Drug-Induced Hepatotoxicity and Protection
- RNA modifications and cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Allergic Rhinitis and Sensitization
- Viral gastroenteritis research and epidemiology
- Network Time Synchronization Technologies
First Affiliated Hospital of Xi'an Jiaotong University
2016-2025
Beijing YouAn Hospital
2025
Capital Medical University
2023-2025
Taiyuan Iron and Steel Group (China)
2025
National Institute for Occupational Health and Poison Control
2025
Xi'an Medical University
2025
People's Government of Shaanxi Province
2023-2024
Electric Power Research Institute
2024
Guangdong Pharmaceutical University
2024
NARI Group (China)
2021-2024
Background The relationship between mental and physical disorders is well established, but there less consensus as to the nature of their joint association with disability, in part because additive interactive models co-morbidity have not always been clearly differentiated prior research. Method Eighteen general population surveys were carried out among adults World Mental Health (WMH) Survey Initiative ( n =42 697). DSM-IV assessed using face-to-face interviews Composite International...
Inflammation and autophagy are two critical cellular processes. The relationship between these processes is complex includes the suppression of inflammation by autophagy. However, signaling mechanisms that relieve this autophagy-mediated inhibition to permit a beneficial inflammatory response remain unknown. We find LPS triggers p38α mitogen-activated protein kinase (MAPK)–dependent phosphorylation ULK1 in microglial cells. This inhibited activity, preventing it from binding downstream...
A thermal boundary condition for a double-population lattice Boltzmann equation (TLBE) is introduced and numerically demonstrated. The unknown distribution population at the node decomposed into its equilibrium part nonequilibrium parts, then approximated with first-order extrapolation of populations neighboring fluid nodes. Numerical tests Dirichlet Neumann constraints show that numerical results TLBE together present schemes agree well analytical solutions those finite-volume method.
Hepatocellular carcinoma ( HCC ) is the second most common cause of cancer‐related mortality worldwide. The expression nitric oxide synthase NOS and inhibition autophagy have been linked to cancer cell death. However, involvement serum NO ), not investigated in . In present study, we first established that level was significantly higher hepatitis B virus‐related than liver cirrhosis control (53.60 ± 19.74 vs 8.09 4.17 μmol/L, t = 15.13, P < 0.0001). Using immunohistochemistry, found...
Background Despite the obvious advantages of metagenomic next-generation sequencing (mNGS) in etiological diagnosis various infectious diseases, there are few reports on suspected thoracic and abdominal infections patients with end-stage liver disease (ESLD). Methods Seventy-three ESLD were enrolled from January 2019 to May 2021 due complicated poor response empirical anti-infective treatment. Pleural effusion ascites samples these collected for mNGS detection conventional pathogen culture....
With the rapid development of Information Technology (IT) industry, heat flux in integrated circuit (IC) chips cooled by air has almost reached its limit at about 100W∕cm2. Some applications high technology industries require fluxes well beyond such a limitation. Therefore, search for more efficient cooling becomes one bottleneck problems further IT industry. The microchannel flow geometry offers large surface area transfer and convective coefficient. However, it been hard to implement...
Abstract Persistent hepatic damage and chronic inflammation in liver activate the quiescent stellate cells (HSCs) cause fibrosis (HF). Several microRNAs regulate activation proliferation of HSCs, thereby playing a critical role HF progression. Previous studies have reported that miR‐188‐5p is dysregulated during process HF. However, remains unclear. This study investigated potential HSCs Firstly, we validated expression primary isolated from carbon tetrachloride (CCl 4 )‐induced mice,...
Background: Acute variceal bleeding (AVB), a life-threatening complication of liver cirrhosis, can be effectively treated by endoscopy, but there is risk early rebleeding after endoscopic treatment (EVT). Thrombocytopenia the most common hemostatic abnormality in cirrhosis. However, it still unclear about whether thrombocytopenia increases failure EVT cirrhotic patients with AVB. Objectives: We investigated association between and Design: International multicenter, retrospective study....
To clarify the effect of slag composition changes on slag–metal interface reaction, microstructure CaOSiO 2 Al O 3 MgO system molten refining is analyzed using molecular dynamics simulation. In simulation results, it shown that in slag, SiO bond and AlO mainly exist a tetrahedral coordination, including five structural forms: Q 0 , 1 4 . addition, also exists pentahedral hexahedral coordination. With increase basicity, proportion aluminum–oxygen structure increases, length decreases,...
Abstract Background Individuals who do not match any specific stage in the natural history of chronic hepatitis B are classified into grey-zone, and appropriate management for these patients remains unclear. This study aimed to develop validate a non-invasive model identify grey-zone requiring antiviral therapy (AVT). Methods We retrospectively collected data on 200 AVT (according assessment by parameters from 2010 2023 six hospitals) randomised them development (n=140) validation (n=60)...
Acute‐on‐chronic liver failure (ACLF) is a syndrome characterized by systemic inflammation with high short-term mortality rate. Syndecan-1 (SDC-1) can independently predict the 90-day of patients septic shock. However, role SDC-1 in ACLF remains unknown. In this study, serum levels were examined 2 cohorts, which included 174 patients. And mouse model induced tetrachloride, lipopolysaccharide, and D-galactosamine was established, to evaluate effects sulodexide heparan sulfate (side chains...
Bacteria respond to stressful conditions through multiple pathways, including changes in gene expression patterns and mutations for adaptation. DNA supercoiling is a fundamental regulatory principle of bacterial expression, controlled antagonistically by gyrase topoisomerase I. Nucleoid-associated proteins, such as HU, also regulate interactions with DNA. Here, we identify Escherichia coli protein MsyB HU inhibitor β-clamp binder. fine-tuned under various conditions, where it modulates the...
Objective: To analyze the features of portal vein thrombosis (PVT) in patients with hepatitis B-related cirrhosis and its impact on long-term prognosis. Methods: Clinical data from a cohort May 2009 to August 2020 were analyzed, enhanced CT examination was employed for diagnosis classification PVT. Patients without PVT at baseline enrolled. The endpoint events follow-up death related liver disease, transplantation, cancer, or followed up until December 31, 2023. During follow-up, divided...
Coronavirus disease 2019 (COVID-19) survivors are concerned about the likelihood of developing further diseases. This study examines global trends in scientific research on diabetes associated with COVID-19 from several perspectives. Bibliometric analyses used to undertake a review literature. The Web Science Core Collection (WoSCC) database was acquire bibliographic information related Jan 2020 Dec. 2023. visual map built via advanced CiteSpace 6.2.R6. 7,348 papers were found. Khunti...
Abstract A novel segregated solution procedure for incompressible fluid flow and heat transfer problems is proposed. The new algorithm called CLEAR (Coupled Linked Equations Algorithm Revised). It differs from all SIMPLE-like algorithms in that it solves the improved pressure directly, rather than by adding a correction term, no term dropped derivation of equation. Thus effects neighboring velocity values are fully taken into account, coupling between guaranteed, greatly enhancing...
Acute liver failure (ALF) is a condition with high mortality and morbidity. Fibrosis in chronic disease was extensively researched, whereas fibrosis underlying mechanism acute remains unclear.Hepatitis B virus related ALF patients were recruited to investigate if there ongoing by histology stiffness measurement(LSM) analysis as well markers assay. Sera HMGB1 kinetically detected progression remission stage of ALF. Hepatic stellate cell(HSC) activation explored testing mRNA protein level...
Liver sinusoids serve as the first line of defense against extrahepatic stimuli from intestinal tract. Hepatic stellate cells (HSCs) are pericytes residing in perisinusoidal space that integrate cytokine-mediated inflammatory responses and relay these signals to liver parenchyma. Oxidative stress has been shown promote inflammation during acute failure (ALF). Whether how oxidative is involved HSC ALF remains unclear. Level systemic reflected by superoxide dismutase (SOD). Thus, patients were...