A5100769990- Gut microbiota and health
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Metalloenzymes and iron-sulfur proteins
- Plant Pathogens and Fungal Diseases
- Ovarian cancer diagnosis and treatment
- Wound Healing and Treatments
- Insect Resistance and Genetics
- Natural product bioactivities and synthesis
- Receptor Mechanisms and Signaling
- Nicotinic Acetylcholine Receptors Study
- Immune Cell Function and Interaction
- RNA modifications and cancer
- Meat and Animal Product Quality
- Animal Nutrition and Physiology
- Endometrial and Cervical Cancer Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Epigenetics and DNA Methylation
- Spectroscopy and Chemometric Analyses
- Advanced Graph Neural Networks
- Genetic Associations and Epidemiology
- Microbial Inactivation Methods
- Sphingolipid Metabolism and Signaling
- Child Abuse and Trauma
Hainan University
2021-2025
Sichuan University
2023-2025
West China Hospital of Sichuan University
2023-2025
Guangxi Medical University
2020-2025
Central South University
2024
Hunan Cancer Hospital
2024
Nanjing University of Chinese Medicine
2020-2024
Changzhou University
2024
First Affiliated Hospital of Xi'an Jiaotong University
2024
Jiangxi Agricultural University
2022-2023
Abstract Signal transducer and activator of transcription 3 (STAT3), as a key node in numerous carcinogenic signaling pathways, is activated various tumor tissues plays important roles formation, metastasis, drug resistance. STAT3 considered potential subtarget for therapy. Noncoding RNA (ncRNA) special type transcript. Transforming from “junk” transcripts into molecules involved cell apoptosis, growth, functional regulation, ncRNA has been proven to be closely related epithelial–mesenchymal...
Background Diabetic foot ulcer (DFU) in patients with type 2 diabetes mellitus (T2D) often leads to amputation. Early intervention prevent DFU is urgently necessary. So far, there have been no studies on predictive models associated risk factors. Our study aimed quantify the value of DFU, promote health education, and further develop behavioral interventions reduce incidence DFU. Methods Data from 973 consecutive T2D was collected two hospitals. Patients Guangxi Medical University First...
Rising studies have consistently reported gut bacteriome alterations in schizophrenia (SCZ). However, little is known about the role of virome on shaping SCZ. Here in, we sequenced fecal virome, bacteriome, and host peripheral metabolome 49 SCZ patients health controls (HCs). We compared bacterial community composition specific abundant bacteria HCs. Specific viruses metabolites co-occurring with differential were identified using Multiple Co-inertia Analysis (MCIA). Additionally, construct...
T cell exhaustion is important to protect the host from immunopathology during chronic viral infection, but it also impairs anti-tumor immunity (1-5). A fundamental unresolved question whether and how determined at onset of TCR signaling (6-8). Here we report an unexpected role Themis, a TCR-proximal molecule (9), in exhaustion. Chronic infection mice usually leads survival host. Surprisingly, Themis T-cell conditional knockout died severe CD8(+)-dependent lung showing Themis' importance...
Three new eremophilane sesquiterpenoids (1–3), together with six known analogues, were isolated from the marine-derived fungus Phoma sp. DXH009. Their structures elucidated through detailed NMR and MS spectroscopic analysis, absolute configurations of 1–4 determined by conformational analysis quantum chemical TDDFT-ECD calculation. anti-neuroinflammatory activities evaluated using lipopolysaccharide (LPS)-induced BV2 microglial cells. The results indicated that compound 5 (dihydrosporogen...
Background Childhood adversities (CAs) and stressful life events (SLEs) are linked to depressive, anxiety, PTSD symptoms. However, their interrelationships not well studied. We aimed examine the potential role of symptoms as risk factors for both outcomes, test stress sensitization hypothesis, investigate pathways linking CAs, symptoms, depressive anxiety Methods conducted a cross-sectional study using data from adult participants at baseline (2006-2010) online follow-up (2016) in UK...
Iron-sulfur (Fe-S) clusters are ancient and ubiquitous protein cofactors play irreplaceable roles in many metabolic regulatory processes. Fe-S built distributed to enzymes by dedicated networks. The core components of these networks widely conserved highly versatile. However, proteins often inactive outside their native host species. We sought systematically investigate the compatibility with non-native enzymes. By using collections enzyme orthologs representative entire range prokaryotic...
Abstract Background Genomic selection is widely applied for genetic improvement in livestock crossbreeding systems to select excellent nucleus purebred (PB) animals and improve the performance of commercial crossbred (CB) animals. Most current predictions are based solely on PB performance. Our objective was explore potential application genomic using genotypes CB with extreme phenotypes a three-way system as reference population. Using real genotyped ancestors, we simulated production...
Abstract In the context of severe burn injuries, presence excessive reactive oxygen species (ROS), prolonged microbial infection, and compromised angiogenesis can contribute to metabolic reprogramming macrophages, resulting in a dysregulated inflammatory response that hinders healing process. this study, cerium oxide nanoparticles (CeNPs) are encapsulated within silk fibroin‐poly(e‐caprolactone) polymer create an electrospun PSF/CeNPs nanofiber membrane (PSF/membrane). This is further...
Extensively drug-resistant and hypervirulent Klebsiella pneumoniae (XDR-hvKp) is a new problem for patients in Intensive Care Unit (ICU) can become an even more severe threat if resistant to tigecycline, considered one of the 'last lines defense' drugs. This study collected seven non-replicated tigecycline-resistant XDR-hvKp from performed genome analysis epidemiological investigation using whole equencing (WGS) other methods. All strains this were identified as ST11-KL64 showed high...
In the present study, we surveyed ascomycetes from bamboo of Phyllostachys across Sichuan Province, China. A biphasic approach based on morphological characteristics and multigene phylogeny confirmed seven species, including one new genus, two five host record species. novel genus Paralloneottiosporina is introduced to accommodate Pa. sichuanensis that was collected leaves violascens. Moreover, newly species Bifusisporella isolated P. edulis, were recorded bamboos, four belonging Apiospora,...
Conotoxins constitute a treasury of drug resources and have attracted widespread attention. In order to explore biological candidates from the marine cone snail, we isolated identified three novel conopeptides named as Vi14b, Vi002, Vi003, conotoxin variants Mr3d.1, Mr3e.1, Tx3a.1, known conotoxins (Vi15a, Mr3.8 TCP) crude venoms Conus virgo, marmoreus texile. (I-V, II-VI, III-IV) Tx3a.1 (I-III, IV-V) both showed pattern disulfide connectivity, different that previously established for µ-...
The brown planthopper, Nilaparvata lugens is an economically important pest on rice plants. This species produces macropterous and brachypterous morphs in response to environmental cues, which makes it very difficult control. molecular basis of wing patterning N. still unknown. It necessary identify genes lugens, also clarify the expression differences between morphs. High-throughput deep sequencing transcriptome pad yielded 116 744 580 raw reads 113 042 700 clean reads. All were assembled...